Pilot and Feasibility Program

项目摘要 UAB-UCSD奥布莱恩中心试点和可行性（PAF）赠款计划的主要目标是 为与阿基相关的新的、优秀的和创新的研究提案提供种子基金。这些试点 资金将为合格的调查人员提供一到两年的支持沿着必要的资源， 探索与阿基相关的制药商发起的项目。 UAB-UCSD奥布莱恩中心PAF计划将有一个三方重点与使命1）吸引 初级教师AKI相关研究; 2）使其他领域的研究人员能够探索可行性 AKI相关研究中的新的创新概念;以及3）吸引具有研究专业知识的研究人员， 核心中心的主题领域，以应用他们的专业知识，以AKI相关的问题。PAF计划已经 在这次使命中取得成功。有很高的经常性兴趣，平均每年有19份申请， 回应我们的RFA。所有资助的申请都被我们的研究部门评为非常有价值， 由我们的校内专家组成。该计划已招募了12名医学科学家和11名博士。科学家们， 包括来自UAB和UCSD以外机构的有前途的教师。23名调查员中有18名获得资助 通过该计划，阿基领域的新成员，约83%仍在肾脏相关研究中。这些 研究人员已经证明了显着的生产力，包括39同行评议的论文发表的试点 在这个周期内资助的人。目前，23名受助人的成功率为66.7%， 获得后续的校外资助。UAB-UCSD奥布莱恩中心PAF计划将继续 利用UAB和UCSD的机构资源（本周期为335，000美元），这将允许 增加对我们试点项目接受者的总投资。每年三至四个奖项将继续 由该计划支持，其中两个由奥布莱恩中心基金支持，另外1-2个由 机构资金。 UAB-UCSD奥布莱恩中心PAF计划的最终目标是提供足够的资源， 培训试点研究人员，以开展推进阿基治疗的研究。

Project Summary The principal objective of the UAB-UCSD O'Brien Center Pilot and Feasibility (PAF) Grants Program is to provide seed funds for new, outstanding, and innovative research proposals related to AKI. These pilot funds will provide eligible investigators with one to two years of support along with the resources necessary to explore investigator-initiated projects related to AKI. The UAB-UCSD O'Brien Center PAF Program will have a tri-partite focus with a mission 1) to attract junior faculty to AKI-related research; 2) enable established investigators in other fields to explore the feasibility of new, innovative concepts in AKI-related research; and 3) entice investigators with research expertise in the Core Center's thematic areas to apply their expertise to AKI-related questions. The PAF Program has been successful in this mission. There is a high level of recurring interest, with an average of 19 applications/year in response to our RFAs. All funded applications were judged to be highly meritorious by our study section, which consists of our intramural experts. The Program has recruited 12 physician-scientists and 11 Ph.D. scientists, including promising faculty from institutions outside UAB and UCSD. Eighteen of the 23 investigators funded by this program were new to the AKI field, and about 83% have remained in kidney-related research. These investigators have demonstrated significant productivity, including 39 peer-reviewed papers published by pilot recipients funded during this cycle. At present, collectively the 23 recipients have a 66.7% success rate in obtaining subsequent extramural funding. The UAB-UCSD O'Brien Center PAF Program will continue to leverage institutional resources ($335,000 during the present cycle) at both UAB and UCSD, which will permit an increase in the total investment for our Pilot Program recipients. Three to four awards per year will continue to be supported by this program, with two supported by O'Brien Center funds and the additional 1-2 from institutional funds. The ultimate goal of the UAB-UCSD O'Brien Center PAF program is to provide sufficient resources and training for pilot investigators to pursue research that advances the treatment of AKI.