Norovirus replication and immune evasion

诺如病毒复制和免疫逃避

• 批准号: nhmrc : 1083139
• 负责人: A/Pr Jason Mackenzie
• 金额: $ 42.27万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/norovirus-replication-immune-evasion/518916
• 关键词: Norovirus; replication; immune; evasion

Viral gastroenteritis poses an enormous burden in public health and is an emerging problem due to the acute nature of the infection process. We aim to understand how our bodies react to infection with Noroviruses, in particular how our immune system is triggered and unfortunately avoided during an infectious episode. We also aim to determine how Noroviruses utilized host components and pathways to facilitate infection in the body.

病毒性肠胃炎对公共卫生造成巨大负担，并且由于感染过程的急性性质而成为一个新出现的问题。我们的目标是了解我们的身体如何对诺如病毒感染作出反应，特别是我们的免疫系统如何被触发，并在感染事件中不幸地避免。我们还旨在确定诺如病毒如何利用宿主成分和途径来促进体内感染。