The dengue virus glycoprotein NS1 binds cholesterol and mediates cellular activation

登革热病毒糖蛋白 NS1 结合胆固醇并介导细胞激活

• 批准号: nhmrc : 1067226
• 负责人: A/Pr Jason Mackenzie
• 金额: $ 42.14万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/dengue-virus-glycoprotein-cellular-activation/455290
• 关键词: dengue; virus; glycoprotein; NS1; binds

Cholesterol has been shown to play a vital role in the life cycle of many viruses. This project will investigate the basis of dengue virus interaction with this important host molecule and along with investigations of how dengue is able to stimulate host cells, will provide new insights into the way these viruses cause severe disease. Findings from this study will also aid in the development of new drug strategies for dengue and related viruses such as West Nile virus.

胆固醇已被证明在许多病毒的生命周期中起着至关重要的作用。该项目将调查登革热病毒与这种重要的宿主分子相互作用的基础，并沿着调查登革热如何能够刺激宿主细胞，将为这些病毒引起严重疾病的方式提供新的见解。这项研究的结果也将有助于开发针对登革热和西尼罗河病毒等相关病毒的新药策略。