Norovirus replication and pathogenesis

诺如病毒复制和发病机制

• 批准号: nhmrc : 1010327
• 负责人: A/Pr Jason Mackenzie
• 金额: $ 34.21万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/norovirus-replication-pathogenesis/109482
• 关键词: Norovirus; replication; pathogenesis

Viral infections of the gut are one of the most debilitating infections one can suffer from. Noroviruses are the most common causative agents of viral-associated gastroenteritis but unfortunately little is known regarding their biology and pathogenesis. Our study aims to investigate the replication and pathogenesis of a mouse norovirus to shed light on similar aspects relating to human norovirus infection. We aim to understand how virus infection in cells leads to disease symptoms.

肠道病毒感染是最衰弱的感染之一，可以遭受。诺如病毒是病毒相关性胃肠炎最常见的病原体，但不幸的是，对其生物学和发病机制知之甚少。我们的研究旨在探讨小鼠诺如病毒的复制和发病机制，以阐明与人类诺如病毒感染相关的类似方面。我们的目标是了解细胞中的病毒感染如何导致疾病症状。