Complement in the Pathogenesis of Autoimmune Arthritis
补体在自身免疫性关节炎发病机制中的作用
基本信息
- 批准号:10255878
- 负责人:
- 金额:$ 34.21万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-23 至 2021-02-18
- 项目状态:已结题
- 来源:
- 关键词:AddressAdoptedAffectAnimal ModelAntibodiesAntigensAppearanceArthritisAttentionAutoantibodiesAutoantigensAutoimmune DiseasesBiological MarkersBiopsyBloodBlood specimenCellsClinical TrialsComplementComplement ActivationComplement Factor HDevelopmentDiagnosisDiseaseDisease modelDisease remissionFibroblastsFundingGenerationsGoalsGrantHumanImmuneIndividualInflammationInflammatoryInflammatory ArthritisInjuryJointsKnowledgeLectinLungMannose Binding LectinMediator of activation proteinMedicineMucositisMusNatural HistoryNatural ImmunityOutcomePathogenesisPathogenicityPathway interactionsPatientsPatternPhasePhenotypePlayPopulationPositioning AttributeProcessProteinsRegulationReportingRheumatoid ArthritisRoleSamplingSerine ProteaseSynovial CellSynovial MembraneSynovitisSystemSystemic Lupus ErythematosusTherapeuticTissuesTranslatingTranslational ResearchUnited States National Institutes of HealthWorkautoimmune arthritisbone erosioncell typecitrullinated proteincomplement pathwaycomplement systemdisabilityficolinhuman diseasehuman modelimmunoregulationimprovedin vivoinformation modelinhibitor/antagonistinsightmouse modelmucosal sitenatural antibodiesneoantigensnext generationnovelpathogenpatient subsetspre-clinicalprognosticprogramsskillssocietal coststargeted treatmenttissue injury
项目摘要
The complement system is a major pro-inflammatory and immunomodulatory pathway and plays a central role
in the mechanisms that drive the pathogenesis of experimental murine models of human rheumatoid arthritis
(RA). In these murine models, inappropriate complement activation that is directed to self-tissues drives initial
cellular influx into the joint as well as synovial inflammation and bone erosions. However, despite the extensive
insights into the murine disease that we have developed with support of this grant, including the activation
pathways involved, how control of the system is overcome and how individual effector pathways promote
tissue damage, we do not know how the complement system plays a pathogenic role in patients with RA.
Recent findings in our studies of the human disease have identified a prolonged preclinical phase in RA
characterized by the presence of circulating autoantibodies and mucosal inflammation that appears to drive the
initial break in tolerance to citrullinated self-antigens. Following that asymptomatic phase, where complement
activation is present in the mucosal site but not systemically, it is likely that complement activation and effector
mechanisms are then especially important as the disease transitions to the very early phases of synovitis when
circulating autoantibodies directed against citrullinated proteins initially react with antigens which develop and
are displayed in the joint. To build our understanding of the human disease and translate information from
models of disease to patients themselves, the major focus of this competing renewal proposal is to understand
how the complement system is involved in the early synovitis in RA. We are especially well positioned to
accomplish this important goal, as with other support mechanisms we are able to identify and follow subjects
from the preclinical period into the very first appearance of synovitis and the diagnosis of RA. By obtaining
synovial biopsies, a skill set also developed in our program in the last 3-4 years through other funding, and
informative blood samples from patients in this important transition period, we will work to characterize the role
of complement activation as well as its regulatory and effector mechanisms in the initial development of
inflammatory arthritis and synovitis in patients. In addition, as there are distinct sub-types of RA, designated
pathotypes, which have prognostic importance, we will determine what complement activation processes are
associated with individual pathotypes. Finally, we will focus special attention on a major synovial cell type in
human RA, which are highly inflammatory fibroblast-like synoviocytes, whose importance is increasingly
understood and for which there are reported complement signatures in unbiased omics studies. We will define
the mechanisms by which complement interacts with this cell type, both with regard to how complement is
activated as well as defining the phenotypic changes in these cells following activation. A major goal in these
studies is to use information gained to inform the use of current and next generation complement therapeutics
in this important human autoimmune disease.
补体系统是一个主要的促炎和免疫调节途径,并发挥核心作用
在驱动人类类风湿性关节炎实验小鼠模型发病机制中,
(RA)。在这些鼠模型中,针对自身组织的不适当的补体激活驱动初始补体激活。
细胞流入关节以及滑膜炎症和骨侵蚀。然而,尽管广泛
深入了解我们在这笔赠款的支持下开发的鼠疾病,包括激活
涉及的途径,如何克服系统的控制,以及个体效应途径如何促进
组织损伤,我们不知道补体系统如何在RA患者中发挥致病作用。
在我们对人类疾病的研究中,最近的发现已经确定了RA的临床前阶段延长
其特征在于循环自身抗体和粘膜炎症的存在,这些抗体和粘膜炎症似乎驱动
对瓜氨酸化自身抗原耐受性的最初破坏。在无症状阶段之后,
如果补体激活存在于粘膜部位,但不存在于全身,则补体激活和效应物可能是
当疾病过渡到滑膜炎的非常早期阶段时,
针对瓜氨酸化蛋白的循环自身抗体最初与抗原反应,
在关节中显示。建立我们对人类疾病的理解,
疾病模型的病人自己,这一竞争更新建议的主要重点是了解
补体系统如何参与RA的早期滑膜炎。我们特别有能力
实现这一重要目标,与其他支持机制一样,我们能够确定和跟踪主题
从临床前阶段到滑膜炎的首次出现和RA的诊断。通过获得
滑膜活检,这是我们项目在过去3-4年中通过其他资助开发的一套技能,
在这个重要的过渡时期,我们将努力描述患者的血液样本的作用,
补体激活及其调节和效应机制在最初的发展,
炎性关节炎和滑膜炎。此外,由于RA有不同的亚型,
病理类型,具有预后重要性,我们将确定补体激活过程是什么
与个体病理类型相关。最后,我们将特别关注一种主要的滑膜细胞类型,
人RA是高度炎性成纤维细胞样滑膜细胞,其重要性日益增加
理解并且在无偏组学研究中报道了其补体特征。我们将定义
补体与这种细胞类型相互作用的机制,无论是关于补体是如何
活化以及定义活化后这些细胞中的表型变化。其中一个主要目标是
研究的目的是利用获得的信息,为当前和下一代补体疗法的使用提供信息。
在这个重要的人类自身免疫性疾病中。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Vernon Michael Holers其他文献
Vernon Michael Holers的其他文献
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{{ truncateString('Vernon Michael Holers', 18)}}的其他基金
Center for Mucosal Immunobiology and Rheumatic Disease Pathogenesis
粘膜免疫生物学和风湿病发病机制中心
- 批准号:
10277290 - 财政年份:2021
- 资助金额:
$ 34.21万 - 项目类别:
Center for Mucosal Immunobiology and Rheumatic Disease Pathogenesis Administrative Core
粘膜免疫生物学和风湿性疾病发病机制中心行政核心
- 批准号:
10277291 - 财政年份:2021
- 资助金额:
$ 34.21万 - 项目类别:
Center for Mucosal Immunobiology and Rheumatic Disease Pathogenesis
粘膜免疫生物学和风湿病发病机制中心
- 批准号:
10700077 - 财政年份:2021
- 资助金额:
$ 34.21万 - 项目类别:
Center for Mucosal Immunobiology and Rheumatic Disease Pathogenesis Administrative Core
粘膜免疫生物学和风湿性疾病发病机制中心行政核心
- 批准号:
10700078 - 财政年份:2021
- 资助金额:
$ 34.21万 - 项目类别:
Novel Therapeutic Approaches for Lupus Nephritis
狼疮性肾炎的新治疗方法
- 批准号:
10190935 - 财政年份:2020
- 资助金额:
$ 34.21万 - 项目类别:
Novel Therapeutic Approaches for Lupus Nephritis
狼疮性肾炎的新治疗方法
- 批准号:
10615186 - 财政年份:2020
- 资助金额:
$ 34.21万 - 项目类别:
Novel Therapeutic Approaches for Lupus Nephritis
狼疮性肾炎的新治疗方法
- 批准号:
10403435 - 财政年份:2020
- 资助金额:
$ 34.21万 - 项目类别:
Novel Therapeutic Approaches for Lupus Nephritis
狼疮性肾炎的新治疗方法
- 批准号:
10033331 - 财政年份:2020
- 资助金额:
$ 34.21万 - 项目类别:
Complement in the Pathogenesis of Autoimmune Arthritis
补体在自身免疫性关节炎发病机制中的作用
- 批准号:
9044728 - 财政年份:2015
- 资助金额:
$ 34.21万 - 项目类别:
Evolving Adaptive and Effector Mechanisms from Pre-RA through Established Disease
从 RA 前期到已确定疾病的适应性和效应机制的演变
- 批准号:
9323969 - 财政年份:2014
- 资助金额:
$ 34.21万 - 项目类别:
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