Center for Mucosal Immunobiology and Rheumatic Disease Pathogenesis Administrative Core

粘膜免疫生物学和风湿性疾病发病机制中心行政核心

• 批准号: 10700078
• 负责人: Vernon Michael Holers
• 金额: $ 16.75万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-10 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10700078
• 关键词: Administrator; Advertisements; Advisory Committees; Annual Reports; Area; Autoimmune Diseases; Award; Biological; Blood Cells; Budgets; Center Core Grants; Chronic; Clinical; Collaborations; Colorado; Communication; Communication Programs; Communities; Consultations; Core Facility; Data; Development; Disease; Down Syndrome; Faculty; Financial Support; Foundations; Funding; Goals; Grant; Growth; Human Resources; Immune; Immunobiology; Individual; Industry; Inflammation; Infrastructure; International; Knowledge; Leadership; Letters; Medicine; Methods; Mission; Modeling; Monitor; Mucosal Immune System; Mucous Membrane; Names; National Institute of Arthritis, and Musculoskeletal, and Skin Diseases; Newsletter; Organ; Pathogenesis; Pathway interactions; Patients; Phase; Prevention; Process; Program Development; Program Reviews; Reporting; Request for Applications; Research; Research Personnel; Research Support; Resources; Rheumatism; Role; Scholars Program; Self Tolerance; Series; Services; Specimen; Support Groups; Technology Assessment; Time; Tissues; Universities; Visit; base; biomarker development; career; career development; catalyst; cohort; cost; direct application; discount; dysbiosis; experience; host-microbe interactions; human disease; immune activation; improved; innovation; interest; medical schools; member; new technology; novel; operation; outreach; preclinical study; predictive marker; professor; programs; satisfaction; senior faculty; skills; social communication; social media; success; symposium; therapeutic development

The Administrative Core will support the 43 members of the University of Colorado (CU) NIAMS P30 Rheumatic Disease Research Resource Center (RDRRC) in all aspects of study implementation, management, execution, regulatory compliance and reporting. The overall goal of this Administrative Core is to enhance and expand the research base by providing members a direct line for Center communication, organized access to Research Resource Core consultation and member discounts, and participation in all of the Programs outlined in the proposal. Dr. Michael Holers will serve as the Administrative Core Director, and Dr. Kristi Kuhn will serve the function of Associate Director. The Center Administrator, Ms. Lindsay McBride, will manage the fiscal aspects, and Ms. Becky Alberti-Powell will serve as the conduit for communication and outreach. The Enrichment Program will be headed up by Dr. Holers, with a focus throughout on early career development. As part of this, a Pilot and Feasibility Grants Program will be overseen by Dr. Robert Fuhlbrigge, Dr. Kristi Kuhn will integrate a Specific Aims and Grants Pre-Submission Review Program into the existing strong CU CTSA-supported program, and as well a Visiting Professor and Novel Technologies Review Series will be organized and managed. Dr. Kevin Deane will lead the Social Media and Communications Program. An innovative Patient Impact Program, including both Biomarker and Therapeutic Development components that will be integrated with the CU Innovations Center, will be co-directed by Dr. Holers and Dr. Ashley Frazer-Abel. In addition to ongoing RDRRC support, in 2016 the Dean of the School of Medicine (SOM) funded four $20M Transformational Research programs modeled on the P30 mechanism to bolster core facilities on the campus. As a result, a strong infrastructure is in place upon which to build new innovative cores within this RDRRC and also integrate through pilot funding their utilization with already established cores. The Executive Committee, consisting of the Center Director and Associate Director, the Research Resource Core leadership and additional CU faculty members with extensive core activities experience, will continually review, prioritize and appropriately direct requests for RDRRC Core access. The overall scientific leadership is bolstered by incorporation of an Advisory Committee of recognized internal CU and external experts chaired by Dr. Joaquin Espinosa, Executive Director of the Linda Crnic Down Syndrome Center and an internationally recognized expert in the use of data rich pipeline methods to explore the immune basis for complications of trisomy 21. With many unique resources focused on the role of the mucosa in the pathogenesis of human disease, the CU RDRRC will be a national resource, as confirmed by multiple external letters of support. The CU SOM Dean and Department of Medicine will also provide financial support for pilot grants to enhance the success of this RDRRC. Overall, the mission of the Administrative Core to promote research in the area of rheumatic disease, with a special emphasis on early career development and improving disease treatment and prevention.

行政核心将支持科罗拉多大学（CU）NIAMS P30的43名成员 风湿病研究资源中心（RDRRC）在研究实施的各个方面， 管理、执行、法规遵从性和报告。该行政核心的总体目标是 通过为会员提供中心沟通的直线，增强和扩大研究基础， 有组织地获得研究资源核心咨询和会员折扣，并参与所有 提案中列出的方案。Michael Holers博士将担任行政核心主任， 博士Kristi Kuhn将担任副主任。中心管理员林赛麦克布莱德女士 将管理财政方面，贝基·阿尔伯蒂·鲍威尔女士将担任沟通渠道， 外展充实计划将由Holers博士领导，重点是早期职业生涯 发展作为其中的一部分，一个试点和可行性赠款计划将由罗伯特·富尔布里奇博士监督， 博士Kristi Kuhn将把一个特定目标和赠款预提交审查计划整合到现有的 强大的CU CTSA支持的计划，以及访问教授和新技术评论系列 将被组织和管理。Kevin Deane博士将领导社交媒体和通信项目。一个 创新的患者影响计划，包括生物标志物和治疗开发组件， 将与CU创新中心整合，将由Holers博士和阿什利弗雷泽-阿贝尔博士共同指导。 除了持续的RDRRC支持，在2016年医学院院长（SOM）资助了四个2000万美元 以P30机制为模型的转型研究计划，以支持校园的核心设施。 因此，一个强大的基础设施已经到位，可以在该RDRRC内建立新的创新核心， 还通过试点供资将其利用与已建立的核心资源结合起来。执行委员会， 由中心主任和副主任，研究资源核心领导， 具有丰富核心活动经验的其他CU教师，将不断审查，优先考虑， 适当地直接请求RDRRC核心访问。整体科学领导力得到以下方面的支持： 成立一个咨询委员会，由公认的CU内部和外部专家组成，由Joaquin博士担任主席 埃斯皮诺萨是琳达克尼克唐氏综合症中心的执行主任，也是国际公认的 专家采用数据丰富的流水线方法探讨21三体并发症的免疫基础。 由于许多独特的资源集中在粘膜在人类疾病发病机制中的作用，CU 正如多封外部支持信所证实的那样，恢复民主与和解中心将是一个国家资源。CU SOM院长 和医学部也将提供财政支持的试点赠款，以提高这一成功 RDRRC。总的来说，行政核心的使命是促进风湿病领域的研究， 特别强调早期职业发展和改善疾病治疗和预防。