Mathematically Rigorous Results In Sequence Matching.

序列匹配中严格的数学结果。

• 批准号: 10261218
• 负责人: John Spouge
• 金额: $ 0.24万
• 依托单位: NATIONAL LIBRARY OF MEDICINE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10261218
• 关键词: Architecture; Benchmarking; Biological Process; Databases; Goals; Mathematics; Population; Proteins; Retrieval; Sampling; Work; base; improved; interest; molecular sequence database; programs

Our previous work showed that false discovery rates performed better than E-values. If a database accumulates random samples from all available sequences (the "population"), E-values by necessity increase, whereas false discovery rates are stable. During our previous work on improving iterative homology searches using false discovery rates in place of E-values, we discovered that no database was available for benchmarking our programs to document our progress. Accordingly, we developed an appropriate benchmarking domain database, MultiDomainBenchmark.

我们以前的工作表明，错误发现率比E值更好。如果一个数据库从所有可用的序列（“总体”）中积累随机样本，E值必然会增加，而错误发现率是稳定的。在我们之前使用错误发现率代替E值改进迭代同源性搜索的工作中，我们发现没有数据库可用于对我们的程序进行基准测试以记录我们的进展。因此，我们开发了一个适当的基准领域数据库，MultiDomainBenchmark。

项目成果

ESTIMATING THE GUMBEL SCALE PARAMETER FOR LOCAL ALIGNMENT OF RANDOM SEQUENCES BY IMPORTANCE SAMPLING WITH STOPPING TIMES.

• DOI: 10.1214/08-aos663
• 发表时间: 2009-12-01
• 期刊: Annals of statistics
• 影响因子: 4.5
• 作者: Park Y;Sheetlin S;Spouge JL
• 通讯作者: Spouge JL

Empirical null estimation using zero-inflated discrete mixture distributions and its application to protein domain data.

• DOI: 10.1111/biom.12779
• 发表时间: 2018-06
• 期刊: Biometrics
• 影响因子: 1.9
• 作者: Gauran IIM;Park J;Lim J;Park D;Zylstra J;Peterson T;Kann M;Spouge JL
• 通讯作者: Spouge JL

New finite-size correction for local alignment score distributions.

• DOI: 10.1186/1756-0500-5-286
• 发表时间: 2012-06-12
• 期刊: BMC research notes
• 影响因子: 1.8
• 作者: Park Y;Sheetlin S;Ma N;Madden TL;Spouge JL
• 通讯作者: Spouge JL

Objective method for estimating asymptotic parameters, with an application to sequence alignment.

估计渐近参数的客观方法，并应用于序列比对。

• DOI: 10.1103/physreve.84.031914
• 发表时间: 2011-09
• 期刊: Physical review. E, Statistical, nonlinear, and soft matter physics
• 作者: Sheetlin S;Park Y;Spouge JL
• 通讯作者: Spouge JL