UAB Pilot Center for Precision Animal Modeling (C-PAM) - Resource and Service Section

UAB 精密动物建模试点中心 (C-PAM) - 资源和服务部分

• 批准号: 10260618
• 负责人: Deeann Wallis-Schultz
• 金额: $ 22.82万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-10 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10260618
• 关键词: Animal Model; Animal Testing; Animals; Archives; Area; Biochemical; Biocompatible Materials; Bioinformatics; Biological; Biological Assay; Caenorhabditis elegans; Clinical; Collaborations; Communities; Computer software; Consultations; Data; Databases; Disease; Disease model; Ensure; Fee-for-Service Plans; Future; Genetic; Goals; Individual; Intervention; Lead; Mission; Modeling; Mus; Musculoskeletal Diseases; Neurodevelopmental Disorder; Pathogenicity; Patients; Phase; Phenotype; Quality Control; Rattus; Research Personnel; Resources; Rodent; Services; Ships; Therapeutic; Time; United States National Institutes of Health; Variant; Work; Zebrafish; ciliopathy; clinical center; cost; data management; design; human disease; in vivo Model; innovation; insight; model development; mutant; outreach; pre-clinical; precision medicine; repository; screening; targeted treatment; therapeutic evaluation

ABSTRACT (RESOURCE AND SERVICE SECTION) The overall goal of the UAB Center for Precision Animal Modeling (C-PAM) is to establish pipelines for preclinical scientific discovery, patient-driven disease modeling, and development of precision medicine-center clinical interventions. C-PAM is accomplishing this through a seven-phase pipeline from variant nomination to animal model characterization and preclinical treatment. The Resource and Service Section (RSS) supports C-PAM by working in several areas of the pipeline to support the Center's mission including Phases IV: Services and Shipment, V: Phenotyping, and VII: Special Services. Importantly, the RSS provides access to enhanced services in Phase VII that are difficult to accomplish in most individual labs and are not readily available through any other mechanism, or are prohibitively costly in terms of both expense and/or time impediments. The RSS provides a bridge between all other components in C-PAM and outside investigators. We are a checkpoint that helps ensure quality control, data management, and data input into our Bioinformatics database and C-PAM Variant Portal. We archive and distribute models created by the DMU to NIH-sponsored national repositories and/or outside investigators. We facilitate high level, detailed scientific dialogues between our team and both external and internal investigators and we provide animals for phenotype assessment in collaboration with the DMU and the Pre/Co-clinical Section. The goal of these conversations is to lead to new collaborations resulting in detailed secondary phenotyping through UAB Core Resource facilities that validates variant pathogenicity, provides new biological insights, and promotes targeted therapeutics testing of the animal models generated by the C-PAM pipeline. The overall aims of the UAB C-PAM RSS are: Aim 1) Acquire and document mutant animal model strains and biomaterials from the Disease Modeling Unit. This will include rodents (mice and rats), zebrafish, and C. elegans. Aim 2) Characterize, expand, and distribute resources created by the UAB C-PAM. Aim 3) Provide access to unique C-PAM quality-controlled services developed by the Center on a fee-for-service basis. This will also include a component of outreach and will provide expert consultation services to help investigators design the most effective functional assays and therapeutic testing strategies.

摘要（资源和服务部分） UAB精密动物建模中心（C-PAM）的总体目标是建立临床前的管道 科学发现，患者驱动的疾病建模以及精确药物中心临床的发展 干预措施。 C-PAM通过从变异提名到动物的七阶段管道来实现这一目标 模型表征和临床前处理。资源和服务部分（RSS）支持C-PAM 在管道的多个地区工作，以支持该中心的任务，包括IV阶段：服务和 货物，V：表型和VII：特殊服务。重要的是，RSS提供了对增强的访问 在大多数个人实验室中难以实现的第七阶段服务，并且不容易通过 任何其他机制，或者在费用和/或时间障碍方面的昂贵。 RSS 在C-PAM和外部研究人员的所有其他组件之间提供桥梁。我们是一个检查站 有助于确保质量控制，数据管理和数据输入我们的生物信息学数据库和C-PAM 变体门户。我们归档和分发由DMU创建的模型向NIH赞助的国家存储库 和/或外部调查人员。我们促进了我们团队与两者之间的高水平，详细的科学对话 外部和内部研究人员，我们为与表型评估提供了动物 DMU和前/共同链接部分。这些对话的目的是导致新的合作 通过UAB核心资源设施进行详细的次级表型，以验证变异的致病性， 提供新的生物学见解，并促进对由动物模型产生的动物模型的靶向治疗测试 C-PAM管道。 UAB C-PAM RS的总体目的是：目标1）获取和记录突变动物 疾病建模单元的模型菌株和生物材料。这将包括啮齿动物（小鼠和大鼠）， 斑马鱼和秀丽隐杆线虫。目标2）表征，扩展和分发由UAB C-PAM创建的资源。 目的3）提供了中心在费用服务中开发的独特C-PAM质量控制的服务 基础。这还将包括外展活动的组成部分，并将提供专家咨询服务以帮助 研究人员设计了最有效的功能测定和治疗测试策略。