Safer Approaches to CRC Chemoprevention
更安全的 CRC 化学预防方法
基本信息
- 批准号:10260715
- 负责人:
- 金额:$ 21.75万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-12-15 至 2023-11-30
- 项目状态:已结题
- 来源:
- 关键词:AdjuvantAdministrative SupplementAfrican AmericanAlabamaAmerican IndiansAnti-Inflammatory AgentsAreaBloodCaloriesCancer BurdenCancer CenterCancer Death RatesCancer EtiologyCaucasiansCenters for Disease Control and Prevention (U.S.)Cessation of lifeCitiesClinicalColonic PolypsColonoscopyColorectal CancerColorectal NeoplasmsCommunitiesDataDietDisease-Free SurvivalEconomically Deprived PopulationEnvironmentEnvironmental Risk FactorExposure toFatty acid glycerol estersGene ExpressionGeneticGenetic Predisposition to DiseaseGenomicsGoalsHeavy MetalsHouseholdImmune TargetingIncidenceIndividualInflammationInflammatoryInstitutesLaboratoriesLow incomeMalignant NeoplasmsMarriageMediatingMetal exposureMutationNot Hispanic or LatinoObesityOklahomaOutcomeOutcomes ResearchPesticidesPopulationPreventionRaceResearchResearch PersonnelRiskRisk FactorsRisk MarkerRuralSamplingSerumSmokingTissuesUnderserved PopulationUniversitiesVariantbasecancer chemopreventioncancer health disparitychemokinecolon cancer patientscolorectal cancer riskcytokineexperiencehigh riskimprovedinflammatory markerinsertion/deletion mutationmedically underservedmetabolomicsmetropolitanmortalitynoveltranscriptome sequencingtranscriptomicstribal Nationunderserved area
项目摘要
Abstract/Summary
Administrative Supplement toR01 CA213987 “Safer approaches to CRC Chemoprevention”
Understanding genomic and metabolomic risk factors of CRC in American Indians Vs Caucasians
of Oklahoma.
This application responds to the PA-18-842 “Administrative Supplements to Support Cancer Disparity
Collaborative Research”, and is focused on colorectal cancer (CRC). The long- term goal is to improve
community and clinical CRC-related practice for American Indians (AIs) and African Americans (AAs)
compared to that of Caucasians (mainly non-Hispanic whites) in Oklahoma. CRC is the second most
common cause of cancer-related deaths in both Oklahomans and the US population as a whole. In
general, Oklahomans have higher incidence and mortality for most cancers – this is particularly so for
CRC where deaths are >21% greater than the US average CRC death rate. It is particularly concerning
that Oklahoman AIs have a staggering 63% greater incidence rates >51% higher mortality rates for CRC
than the national rate drawn mostly from Caucasian populations. Oklahoman AAs also have higher
incidence (~20%) and mortality (54.9%) compared to overall US mortality rates. At present no in-depth
studies have been performed to understand the risk factors that contribute to these CRC incidence and
mortality rates in Oklahoma’s AIs and AAs compared to Caucasians. Thus, this collaborative
administrative supplement focuses on understanding the genomic and metabolomic risk factors with
specific focus on the inflammation in CRC patients of AI, AA and Caucasian descent. Our collaborative
team includes laboratory based basic researchers (C.V. Rao, Ph.D; H. Yamada, Ph.D, K. Morris, M.D, C.
Xu, Ph.D,) and cancer disparities researchers M. Doescher, M.D, from the Stephenson Cancer Center
and Upender Manne, Ph.D, (University of Alabama, at Birmingham) the latter with expertise in AA cancer
disparities. Our specific goals in this administrative supplement are to establish whether: i) enhanced
genomic mutational burden; ii) altered gene expression; and iii) higher systemic and colonic inflammation
are key factors contributing to the higher incidence and mortality of Oklahoman AIs and AAs as compared
to Oklahoma Caucasian populations. The outcomes will provide a basis to develop novel anti-
inflammatory (R01 213987 specific objective) and immune targeted approaches as adjuvants to improve
disease free survival in AI and AA CRC patients.
摘要/概要
R 01 CA 213987“更安全的CRC化学预防方法”的行政补充
了解美国印第安人与高加索人中CRC的基因组学和代谢组学风险因素
来自俄克拉荷马州。
本申请响应PA-18-842“支持癌症差异的行政补充”
合作研究”,并专注于结直肠癌(CRC)。我们的长期目标是
美洲印第安人(AI)和非裔美国人(AA)的社区和临床CRC相关实践
与俄克拉荷马州的高加索人(主要是非西班牙裔白人)相比。CRC是第二大
这是俄克拉荷马州和整个美国人口中癌症相关死亡的常见原因。在
一般来说,俄克拉荷马州的大多数癌症的发病率和死亡率都较高,尤其是
CRC,死亡率比美国平均CRC死亡率高21%。尤其令人关切的是,
俄克拉荷马州的AI有一个惊人的63%以上的发病率>51%的死亡率高CRC
而全国的死亡率主要来自高加索人群。俄克拉荷马州的AA也有更高的
发生率(~20%)和死亡率(54.9%)与美国总体死亡率相比。目前没有深入的
已经进行了研究以了解导致这些CRC发病率的风险因素,
俄克拉荷马州的AI和AAs与白人的死亡率比较。因此,这种合作
行政补充侧重于了解基因组和代谢组学风险因素,
特别关注AI、AA和高加索血统的CRC患者的炎症。我们的协作
团队包括基于实验室的基础研究人员(C. V. Rao,Ph.D; H. Yamada,Ph.D,K. Morris,M.D,C.
和癌症差异研究人员M。Doescher,医学博士,来自斯蒂芬森癌症中心
和Upender Manne博士(位于伯明翰的亚拉巴马大学),后者具有AA癌症的专业知识
差距。我们在本行政补充文件中的具体目标是确定:i)加强
基因组突变负担; ii)改变的基因表达;和iii)更高的全身和结肠炎症
是导致俄克拉荷马州AI和AA的发病率和死亡率较高的关键因素,
到俄克拉荷马州高加索人群。研究结果将为开发新型抗-
炎性(R 01 213987特异性目标)和免疫靶向方法作为佐剂来改善
AI和AA CRC患者的无病生存率。
项目成果
期刊论文数量(19)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Targeting IL-23 for the interception of obesity-associated colorectal cancer.
- DOI:10.1016/j.neo.2023.100939
- 发表时间:2023-11
- 期刊:
- 影响因子:4.8
- 作者:Madka, Venkateshwar;Chiliveru, Srikanth;Panneerselvam, Janani;Pathuri, Gopal;Zhang, Yuting;Stratton, Nicole;Kumar, Nandini;Sanghera, Dharambir K.;Rao, Chinthalapally V.
- 通讯作者:Rao, Chinthalapally V.
Inflammatory Mediators and Gut Microbial Toxins Drive Colon Tumorigenesis by IL-23 Dependent Mechanism.
- DOI:10.3390/cancers13205159
- 发表时间:2021-10-14
- 期刊:
- 影响因子:5.2
- 作者:Panneerselvam J;Madka V;Rai R;Morris KT;Houchen CW;Chandrakesan P;Rao CV
- 通讯作者:Rao CV
Targeting the paracrine hormone-dependent guanylate cyclase/cGMP/phosphodiesterases signaling pathway for colorectal cancer prevention.
- DOI:10.1016/j.semcancer.2018.08.011
- 发表时间:2019-06
- 期刊:
- 影响因子:14.5
- 作者:N. Yarla;H. Gali;Gopal Pathuri;S. Smriti;M. Farooqui;J. Panneerselvam;G. Kumar;Venkateshwar Madka;C. Rao
- 通讯作者:N. Yarla;H. Gali;Gopal Pathuri;S. Smriti;M. Farooqui;J. Panneerselvam;G. Kumar;Venkateshwar Madka;C. Rao
Molecular Mechanisms of Cancer Prevention by Gooseberry (Phyllanthus emblica).
- DOI:10.1080/01635581.2021.2008988
- 发表时间:2022
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Targeting Triglyceride Metabolism for Colorectal Cancer Prevention and Therapy.
针对结直肠癌预防和治疗的甘油三酯代谢。
- DOI:10.2174/1389450122666210824150012
- 发表时间:2022
- 期刊:
- 影响因子:3.2
- 作者:Yarla,Nagendra;Madka,Venkateshwar;Rao,Chinthalapally
- 通讯作者:Rao,Chinthalapally
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Chinthalapally V. Rao其他文献
Mutational disparities in colorectal cancers of White Americans, Alabama African Americans, And Oklahoma American Indians
白种美国人、阿拉巴马州非裔美国人和俄克拉何马州美洲印第安人结直肠癌的突变差异
- DOI:
10.1038/s41698-024-00782-9 - 发表时间:
2024-12-23 - 期刊:
- 影响因子:8.000
- 作者:
Hiroshi Y. Yamada;Madhusmita Rout;Chao Xu;Philip H. O’Neill;Farrukh Afaq;Katherine T. Morris;Dharambir K. Sanghera;Upender Manne;Chinthalapally V. Rao - 通讯作者:
Chinthalapally V. Rao
Targeting PGE<sub>2</sub>/IL-23 Nexus in TME for CRC Prevention and Treatment
- DOI:
10.1016/j.canlet.2023.216553 - 发表时间:
2024-01-28 - 期刊:
- 影响因子:
- 作者:
Chinthalapally V. Rao - 通讯作者:
Chinthalapally V. Rao
Role of lipoxins, resolvins, and other bioactive lipids in colon and pancreatic cancer
- DOI:
10.1007/s10555-011-9311-2 - 发表时间:
2011-10-21 - 期刊:
- 影响因子:8.700
- 作者:
Naveena B. Janakiram;Altaf Mohammed;Chinthalapally V. Rao - 通讯作者:
Chinthalapally V. Rao
Chinthalapally V. Rao的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Chinthalapally V. Rao', 18)}}的其他基金
PREVENT CANCER PRECLINICAL DRUG DEVELOPMENT PROGRAM: PRECLINICAL EFFICACY AND ENDPOINT BIOMARKERS. TASK ORDER TITLE: URINARY BLADDER CANCER PREVENTIO
预防癌症临床前药物开发计划:临床前疗效和终点生物标志物。
- 批准号:
10269136 - 财政年份:2020
- 资助金额:
$ 21.75万 - 项目类别:
EVALUATION OF TWO DIFFERENT CLASSES OF COMPOUNDS (STAT3 INHIBITORS AND SERMS) FOR THE PREVENTION OF URINARY BLADDER CANCER.
评估两类不同类型的化合物(STAT3 抑制剂和 Serms)预防膀胱癌的作用。
- 批准号:
10674662 - 财政年份:2020
- 资助金额:
$ 21.75万 - 项目类别:
EVALUATION OF TWO DIFFERENT CLASSES OF COMPOUNDS (STAT3 INHIBITORS AND SERMS) FOR THE PREVENTION OF URINARY BLADDER CANCER.
评估两类不同类型的化合物(STAT3 抑制剂和 Serms)预防膀胱癌的作用。
- 批准号:
10269139 - 财政年份:2020
- 资助金额:
$ 21.75万 - 项目类别:
ShEEP Request for CTL ImmunoSpot S6 Universal Analyzer
ShEEP 请求 CTL ImmunoSpot S6 通用分析仪
- 批准号:
9795713 - 财政年份:2019
- 资助金额:
$ 21.75万 - 项目类别:
PREVENTION OF CRC BY iNOS AND COX-2 SELECTIVE INHIBITORS
通过 iNOS 和 COX-2 选择性抑制剂预防 CRC
- 批准号:
6815750 - 财政年份:2004
- 资助金额:
$ 21.75万 - 项目类别:
PREVENTION OF CRC BY iNOS AND COX-2 SELECTIVE INHIBITORS
通过 iNOS 和 COX-2 选择性抑制剂预防 CRC
- 批准号:
6952292 - 财政年份:2004
- 资助金额:
$ 21.75万 - 项目类别:
相似海外基金
A Longitudinal Qualitative Study of Fentanyl-Stimulant Polysubstance Use Among People Experiencing Homelessness (Administrative supplement)
无家可归者使用芬太尼兴奋剂多物质的纵向定性研究(行政补充)
- 批准号:
10841820 - 财政年份:2023
- 资助金额:
$ 21.75万 - 项目类别:
Proton-secreting epithelial cells as key modulators of epididymal mucosal immunity - Administrative Supplement
质子分泌上皮细胞作为附睾粘膜免疫的关键调节剂 - 行政补充
- 批准号:
10833895 - 财政年份:2023
- 资助金额:
$ 21.75万 - 项目类别:
Administrative Supplement: Life-Space and Activity Digital Markers for Detection of Cognitive Decline in Community-Dwelling Older Adults: The RAMS Study
行政补充:用于检测社区老年人认知衰退的生活空间和活动数字标记:RAMS 研究
- 批准号:
10844667 - 财政年份:2023
- 资助金额:
$ 21.75万 - 项目类别:
StrokeNet Administrative Supplement for the Funding Extension
StrokeNet 资助延期行政补充文件
- 批准号:
10850135 - 财政年份:2023
- 资助金额:
$ 21.75万 - 项目类别:
2023 NINDS Landis Mentorship Award - Administrative Supplement to NS121106 Control of Axon Initial Segment in Epilepsy
2023 年 NINDS 兰迪斯指导奖 - NS121106 癫痫轴突初始段控制的行政补充
- 批准号:
10896844 - 财政年份:2023
- 资助金额:
$ 21.75万 - 项目类别:
Biomarkers of Disease in Alcoholic Hepatitis Administrative Supplement
酒精性肝炎行政补充剂中疾病的生物标志物
- 批准号:
10840220 - 财政年份:2023
- 资助金额:
$ 21.75万 - 项目类别:
Administrative Supplement: Improving Inference of Genetic Architecture and Selection with African Genomes
行政补充:利用非洲基因组改进遗传结构的推断和选择
- 批准号:
10891050 - 财政年份:2023
- 资助金额:
$ 21.75万 - 项目类别:
Power-Up Study Administrative Supplement to Promote Diversity
促进多元化的 Power-Up 研究行政补充
- 批准号:
10711717 - 财政年份:2023
- 资助金额:
$ 21.75万 - 项目类别:
Administrative Supplement for Peer-Delivered and Technology-Assisted Integrated Illness Management and Recovery
同行交付和技术辅助的综合疾病管理和康复的行政补充
- 批准号:
10811292 - 财政年份:2023
- 资助金额:
$ 21.75万 - 项目类别:
Administrative Supplement: Genome Resources for Model Amphibians
行政补充:模型两栖动物基因组资源
- 批准号:
10806365 - 财政年份:2023
- 资助金额:
$ 21.75万 - 项目类别: