Safer Approaches to CRC Chemoprevention
更安全的 CRC 化学预防方法
基本信息
- 批准号:10260715
- 负责人:
- 金额:$ 21.75万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-12-15 至 2023-11-30
- 项目状态:已结题
- 来源:
- 关键词:AdjuvantAdministrative SupplementAfrican AmericanAlabamaAmerican IndiansAnti-Inflammatory AgentsAreaBloodCaloriesCancer BurdenCancer CenterCancer Death RatesCancer EtiologyCaucasiansCenters for Disease Control and Prevention (U.S.)Cessation of lifeCitiesClinicalColonic PolypsColonoscopyColorectal CancerColorectal NeoplasmsCommunitiesDataDietDisease-Free SurvivalEconomically Deprived PopulationEnvironmentEnvironmental Risk FactorExposure toFatty acid glycerol estersGene ExpressionGeneticGenetic Predisposition to DiseaseGenomicsGoalsHeavy MetalsHouseholdImmune TargetingIncidenceIndividualInflammationInflammatoryInstitutesLaboratoriesLow incomeMalignant NeoplasmsMarriageMediatingMetal exposureMutationNot Hispanic or LatinoObesityOklahomaOutcomeOutcomes ResearchPesticidesPopulationPreventionRaceResearchResearch PersonnelRiskRisk FactorsRisk MarkerRuralSamplingSerumSmokingTissuesUnderserved PopulationUniversitiesVariantbasecancer chemopreventioncancer health disparitychemokinecolon cancer patientscolorectal cancer riskcytokineexperiencehigh riskimprovedinflammatory markerinsertion/deletion mutationmedically underservedmetabolomicsmetropolitanmortalitynoveltranscriptome sequencingtranscriptomicstribal Nationunderserved area
项目摘要
Abstract/Summary
Administrative Supplement toR01 CA213987 “Safer approaches to CRC Chemoprevention”
Understanding genomic and metabolomic risk factors of CRC in American Indians Vs Caucasians
of Oklahoma.
This application responds to the PA-18-842 “Administrative Supplements to Support Cancer Disparity
Collaborative Research”, and is focused on colorectal cancer (CRC). The long- term goal is to improve
community and clinical CRC-related practice for American Indians (AIs) and African Americans (AAs)
compared to that of Caucasians (mainly non-Hispanic whites) in Oklahoma. CRC is the second most
common cause of cancer-related deaths in both Oklahomans and the US population as a whole. In
general, Oklahomans have higher incidence and mortality for most cancers – this is particularly so for
CRC where deaths are >21% greater than the US average CRC death rate. It is particularly concerning
that Oklahoman AIs have a staggering 63% greater incidence rates >51% higher mortality rates for CRC
than the national rate drawn mostly from Caucasian populations. Oklahoman AAs also have higher
incidence (~20%) and mortality (54.9%) compared to overall US mortality rates. At present no in-depth
studies have been performed to understand the risk factors that contribute to these CRC incidence and
mortality rates in Oklahoma’s AIs and AAs compared to Caucasians. Thus, this collaborative
administrative supplement focuses on understanding the genomic and metabolomic risk factors with
specific focus on the inflammation in CRC patients of AI, AA and Caucasian descent. Our collaborative
team includes laboratory based basic researchers (C.V. Rao, Ph.D; H. Yamada, Ph.D, K. Morris, M.D, C.
Xu, Ph.D,) and cancer disparities researchers M. Doescher, M.D, from the Stephenson Cancer Center
and Upender Manne, Ph.D, (University of Alabama, at Birmingham) the latter with expertise in AA cancer
disparities. Our specific goals in this administrative supplement are to establish whether: i) enhanced
genomic mutational burden; ii) altered gene expression; and iii) higher systemic and colonic inflammation
are key factors contributing to the higher incidence and mortality of Oklahoman AIs and AAs as compared
to Oklahoma Caucasian populations. The outcomes will provide a basis to develop novel anti-
inflammatory (R01 213987 specific objective) and immune targeted approaches as adjuvants to improve
disease free survival in AI and AA CRC patients.
摘要/摘要
R01 CA213987“结直肠癌化学预防的更安全方法”行政补编
了解美洲印第安人与高加索人结直肠癌的基因组和代谢危险因素
俄克拉何马州。
此应用程序响应PA-18-842“支持癌症差异的行政补充”
合作研究“,重点是结直肠癌(CRC)。长期目标是改进
美国印第安人(AIS)和非裔美国人(AAS)的社区和临床结直肠癌相关实践
与俄克拉荷马州的高加索人(主要是非西班牙裔白人)相比。CRC是第二大
俄克拉荷马人和整个美国人口癌症相关死亡的共同原因。在……里面
一般说来,俄克拉荷马人的大多数癌症的发病率和死亡率都更高--尤其是对
死亡人数比美国平均CRC死亡率高21%的地区。尤其令人担忧的是
俄克拉荷马州的癌症发病率高出惊人的63%,而结直肠癌的死亡率高出51%
而不是主要来自高加索人口的全国通胀率。俄克拉荷马州AA也有更高的
发病率(~20%)和死亡率(54.9%)与美国总体死亡率相比。目前还没有深入的
已经进行了研究,以了解导致这些结直肠癌发病率和
与高加索人相比,俄克拉何马州的人工智能和人工智能的死亡率。因此,这个协作性
行政补充侧重于了解基因组和代谢风险因素
特别关注AI、AA和高加索血统的CRC患者的炎症。我们的协作
团队包括以实验室为基础的基础研究人员(C.V.Rao,Ph.D.;H.Yamada,Ph.D.,K.Morris,M.D.,C.
和来自斯蒂芬森癌症中心的癌症差异研究人员M.Doescher,M.D.
Upender Manne博士(阿拉巴马大学伯明翰分校),后者拥有AA癌症方面的专业知识
差距。我们在这份行政副刊中的具体目标是确定:i)增强
基因组突变负担;ii)基因表达改变;以及iii)更高的全身和结肠炎症
是俄克拉荷马州AIS和AAS发病率和死亡率较高的关键因素
俄克拉何马州的高加索人。研究结果将为开发新型抗病毒药物提供依据。
炎症(R01 213987特定目标)和免疫靶向方法作为佐剂来改善
AI和AA结直肠癌患者的无病生存。
项目成果
期刊论文数量(19)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Targeting IL-23 for the interception of obesity-associated colorectal cancer.
- DOI:10.1016/j.neo.2023.100939
- 发表时间:2023-11
- 期刊:
- 影响因子:4.8
- 作者:Madka, Venkateshwar;Chiliveru, Srikanth;Panneerselvam, Janani;Pathuri, Gopal;Zhang, Yuting;Stratton, Nicole;Kumar, Nandini;Sanghera, Dharambir K.;Rao, Chinthalapally V.
- 通讯作者:Rao, Chinthalapally V.
Inflammatory Mediators and Gut Microbial Toxins Drive Colon Tumorigenesis by IL-23 Dependent Mechanism.
- DOI:10.3390/cancers13205159
- 发表时间:2021-10-14
- 期刊:
- 影响因子:5.2
- 作者:Panneerselvam J;Madka V;Rai R;Morris KT;Houchen CW;Chandrakesan P;Rao CV
- 通讯作者:Rao CV
Targeting the paracrine hormone-dependent guanylate cyclase/cGMP/phosphodiesterases signaling pathway for colorectal cancer prevention.
- DOI:10.1016/j.semcancer.2018.08.011
- 发表时间:2019-06
- 期刊:
- 影响因子:14.5
- 作者:N. Yarla;H. Gali;Gopal Pathuri;S. Smriti;M. Farooqui;J. Panneerselvam;G. Kumar;Venkateshwar Madka;C. Rao
- 通讯作者:N. Yarla;H. Gali;Gopal Pathuri;S. Smriti;M. Farooqui;J. Panneerselvam;G. Kumar;Venkateshwar Madka;C. Rao
Molecular Mechanisms of Cancer Prevention by Gooseberry (Phyllanthus emblica).
- DOI:10.1080/01635581.2021.2008988
- 发表时间:2022
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Targeting Triglyceride Metabolism for Colorectal Cancer Prevention and Therapy.
针对结直肠癌预防和治疗的甘油三酯代谢。
- DOI:10.2174/1389450122666210824150012
- 发表时间:2022
- 期刊:
- 影响因子:3.2
- 作者:Yarla,Nagendra;Madka,Venkateshwar;Rao,Chinthalapally
- 通讯作者:Rao,Chinthalapally
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Chinthalapally V. Rao其他文献
Mutational disparities in colorectal cancers of White Americans, Alabama African Americans, And Oklahoma American Indians
白种美国人、阿拉巴马州非裔美国人和俄克拉何马州美洲印第安人结直肠癌的突变差异
- DOI:
10.1038/s41698-024-00782-9 - 发表时间:
2024-12-23 - 期刊:
- 影响因子:8.000
- 作者:
Hiroshi Y. Yamada;Madhusmita Rout;Chao Xu;Philip H. O’Neill;Farrukh Afaq;Katherine T. Morris;Dharambir K. Sanghera;Upender Manne;Chinthalapally V. Rao - 通讯作者:
Chinthalapally V. Rao
Targeting PGE<sub>2</sub>/IL-23 Nexus in TME for CRC Prevention and Treatment
- DOI:
10.1016/j.canlet.2023.216553 - 发表时间:
2024-01-28 - 期刊:
- 影响因子:
- 作者:
Chinthalapally V. Rao - 通讯作者:
Chinthalapally V. Rao
Role of lipoxins, resolvins, and other bioactive lipids in colon and pancreatic cancer
- DOI:
10.1007/s10555-011-9311-2 - 发表时间:
2011-10-21 - 期刊:
- 影响因子:8.700
- 作者:
Naveena B. Janakiram;Altaf Mohammed;Chinthalapally V. Rao - 通讯作者:
Chinthalapally V. Rao
Chinthalapally V. Rao的其他文献
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{{ truncateString('Chinthalapally V. Rao', 18)}}的其他基金
PREVENT CANCER PRECLINICAL DRUG DEVELOPMENT PROGRAM: PRECLINICAL EFFICACY AND ENDPOINT BIOMARKERS. TASK ORDER TITLE: URINARY BLADDER CANCER PREVENTIO
预防癌症临床前药物开发计划:临床前疗效和终点生物标志物。
- 批准号:
10269136 - 财政年份:2020
- 资助金额:
$ 21.75万 - 项目类别:
EVALUATION OF TWO DIFFERENT CLASSES OF COMPOUNDS (STAT3 INHIBITORS AND SERMS) FOR THE PREVENTION OF URINARY BLADDER CANCER.
评估两类不同类型的化合物(STAT3 抑制剂和 Serms)预防膀胱癌的作用。
- 批准号:
10674662 - 财政年份:2020
- 资助金额:
$ 21.75万 - 项目类别:
EVALUATION OF TWO DIFFERENT CLASSES OF COMPOUNDS (STAT3 INHIBITORS AND SERMS) FOR THE PREVENTION OF URINARY BLADDER CANCER.
评估两类不同类型的化合物(STAT3 抑制剂和 Serms)预防膀胱癌的作用。
- 批准号:
10269139 - 财政年份:2020
- 资助金额:
$ 21.75万 - 项目类别:
ShEEP Request for CTL ImmunoSpot S6 Universal Analyzer
ShEEP 请求 CTL ImmunoSpot S6 通用分析仪
- 批准号:
9795713 - 财政年份:2019
- 资助金额:
$ 21.75万 - 项目类别:
PREVENTION OF CRC BY iNOS AND COX-2 SELECTIVE INHIBITORS
通过 iNOS 和 COX-2 选择性抑制剂预防 CRC
- 批准号:
6815750 - 财政年份:2004
- 资助金额:
$ 21.75万 - 项目类别:
PREVENTION OF CRC BY iNOS AND COX-2 SELECTIVE INHIBITORS
通过 iNOS 和 COX-2 选择性抑制剂预防 CRC
- 批准号:
6952292 - 财政年份:2004
- 资助金额:
$ 21.75万 - 项目类别:
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