Integrated Health, Behavioral and Economic Research on Current and Emerging Tobacco Products

针对当前和新兴烟草产品的综合健康、行为和经济研究

• 批准号: 10259834
• 负责人: Pamela May Ling
• 金额: $ 400万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-19 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10259834
• 关键词: Acute Lung Injury; Adolescent; Aerosols; Behavior; Behavioral; Biological; Biological Markers; Cardiac health; Characteristics; Cigar; Cigarette; Communication; Communication Programs; Communities; Development; Devices; Dimensions; Doctor of Philosophy; Economic Models; Electronic cigarette; Emerging Tobacco Products; Faculty; Future; General Population; Grant; Health; Health Care Costs; Informatics; Inhalation; Marketing; Mentors; Modified Risk Tobacco Product; Nicotine; Pattern; Perception; Postdoctoral Fellow; Principal Investigator; Regulation; Research; Research Personnel; Rural; Science; System; Temperature; Tobacco; Tobacco Industry; Tobacco use; Vulnerable Populations; Youth; base; behavioral economics; behavioral study; cardiovascular effects; cardiovascular health; career; cigarette smoking; combustible cigarette; design; economic impact; electronic cigarette use; electronic liquid; evidence base; falls; heated tobacco products; improved; programs; respiratory; respiratory health; response; snuff; statistics; tobacco products; tobacco regulation; tobacco regulatory science; tobacco user

PROJECT SUMMARY/ABSTRACT After decades of stability, the tobacco products people use and the way they use them are changing. Cigarette use continues to decline, but e-cigarette, cigar, and moist snuff use are increasing and use of multiple products is becoming more common. New “heat-not-burn” products are being proposed to the FDA as modified risk tobacco products. There is only a limited evidence base to inform regulatory and public communication responses to these changes. The integrative theme of this TCORS is that understanding combined health effects, behavior, and impact analysis will provide actionable information for regulation of and public communications about current and emerging tobacco products. This integration is reflected by the fact that several projects fall within more than one domain. The TCORS' specific aims are: (1) Evaluate the short-term health effects, including respiratory and cardiovascular effects, of e-cigarettes, heat-not-burn, and other tobacco products and how specific tobacco product characteristics influence health effects and behavior; (2) Develop the science base to inform product standards and marketing regulations for these tobacco products, integrating the health and behavioral dimensions of tobacco use with economic models, with particular emphasis on specific product characteristics and previously under-studied short-term effects; and (3) Implement a career enhancement program for postdoctoral fellows, junior faculty, and established faculty who are not currently involved in regulatory science research to build the tobacco regulatory science research community through mentoring, developmental grants, and other support. We will accomplish these aims through 5 projects: (1) Impact of Different E-cigarette Characteristics on Acute Lung Injury; (2) Short-term Cardiovascular Effects of E-cigarettes: Influence of Device Power and E-liquid pH, and How E-cigarettes Compare with Heat-not-burn Products; (3) Cardiovascular Health Effects of Emerging Heat-Not-Burn Tobacco Products; (4) Current and Emerging Tobacco Products in a Rural Context: Influences of Product Characteristics on Perceptions, Behaviors, and Biologic Exposures; and (5) Impact of Changing Tobacco Product Use on Healthcare Costs for General and Vulnerable Populations. Four cores will support these projects: (1) Administration; (2) Career Enhancement; (3) Statistics and Informatics; and (4) Biomarker All projects and cores interact to support each other and increase their collective impact. The health effects (Projects 1, 2, and 3) and behavior (Project 4) projects inform each other and are further integrated through economic models (Project 5) that will improve regulatory impact analyses. Quantifying the health effects of specific design aspects of tobacco products is important for identifying opportunities for regulation. In particular, because benefits far in the future are heavily discounted in the FDA's regulatory impact analysis, identifying short-term health effects is important for accurate regulatory impact assessment.

项目摘要/摘要 经过数十年的稳定性，人们使用的烟草产品以及使用它们的方式正在改变。卷烟 使用继续下降，但是电子烟，雪茄和湿润的使用正在增加和使用多种产品 变得越来越普遍。正在向FDA提出新的“热燃烧”产品作为修改风险 烟草产品。只有有限的证据基础来告知监管和公共交流 对这些变化的响应。该TCOR的综合主题是了解结合健康 效果，行为和影响分析将为监管和公众提供可行的信息 有关当前和新兴烟草产品的通信。这种整合反映了以下事实 几个项目属于一个以上的领域。 TCORS的具体目的是：（1）评估短期 电子烟，热点燃烧和其他的健康作用，包括呼吸和心血管效应 烟草产品以及特定的烟草产品特征如何影响健康的影响和行为； （2） 建立科学基础，以为这些烟草产品的产品标准和营销法规提供信息， 将烟草使用的健康和行为维度与经济模型相结合，特别是 强调特定产品特征和以前研究不足的短期影响； （3） 为博士后研究员，初级教师和成熟的教师实施职业增强计划 目前尚未参与监管科学研究来建立烟草监管科学研究 通过心理，发展赠款和其他支持社区。我们将实现这些目标 通过5个项目：（1）不同电子烟特征对急性肺损伤的影响； （2）短期 电子烟的心血管效应：设备功率和电子液体pH的影响，以及电子烟如何 与热燃烧产品相比； （3）新兴热燃烧烟草的心血管健康影响 产品; （4）在农村环境中的当前和新兴的烟草产品：产品的影响 感知，行为和生物学暴露的特征； （5）改变烟草的影响 产品用于一般和脆弱人群的医疗保健费用。四个核心将支持这些 项目：（1）行政； （2）职业增强； （3）统计和信息学； （4）生物标志物 项目和核心互动以相互支持并增加其集体影响。健康影响 （项目1、2和3）和行为（项目4）项目相互通知，并通过 经济模型（项目5）将改善监管影响分析。量化健康影响 烟草产品的特定设计方面对于确定监管机会很重要。在 特别是，因为未来的好处在FDA的监管影响分析中被大大折扣，所以 确定短期健康影响对于准确的监管影响评估很重要。