Exercise-induced Legacy Health Benefits on Cardiometabolic Risk Factors in Aging Adults with Prediabetes

运动对患有前驱糖尿病的老年人的心脏代谢危险因素的传统健康益处

• 批准号: 10559632
• 负责人: WILLIAM E KRAUS
• 金额: $ 24.15万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-02-01 至 2024-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10559632
• 关键词: Adopted; Adult; Advisory Committees; Aerobic; Aerobic Exercise; Age; Aging; American; Amino Acids; Attenuated; Automobile Driving; Back; Blood specimen; Body Weight decreased; Cardiometabolic Disease; Cardiopulmonary; Chronic Disease; Clinical; Data; Diet; Dyslipidemias; Elderly; Elements; Exercise; Exercise Test; Fasting; Fatty Acids; Follow-Up Studies; Foundations; Glycine; Goals; Guidelines; Health; Health Benefit; Individual; Insulin; Intervention; Investigation; Knowledge; Life Expectancy; Life Style; Light; Lipids; Lipoproteins; Longevity; Maintenance; Mediating; Medicine; Metabolic; Molecular; Older Population; Outcome; Overweight; Participant; Pathway interactions; Physical activity; Physiological; Plasma; Prediabetes syndrome; Proline; Protocols documentation; Public Health; Reporting; Research; Risk; Risk Factors; Risk Reduction; Time; Training Programs; acquired factor; acylcarnitine; age group; age related; aged; arm; blood lipid; burden of illness; cardiometabolic risk; cardiometabolism; cardiorespiratory fitness; design; diabetes prevention program; diet and exercise; disability; exercise intensity; exercise intervention; exercise training; fatty acid oxidation; fitness; follow-up; human old age (65+); improved; metabolomics; middle age; novel; peripheral blood; randomized trial; resilience; sedentary; vigorous intensity

Abstract Exercise training produces substantial health benefits, summarized in the Physical Activity Guidelines Advisory Committee Report and incorporated into the 2008 and 2018 Physical Activity Guidelines for Americans. Despite the well-known benefits, too few individuals adopt exercise as a health maintenance strategy. Thus, determining whether a relatively modest duration of exercise training in middle age can lead to sustained health benefits as individuals progress into older age groups (legacy effects) is of public health and clinical importance. In previously sedentary, overweight middle-aged adults with dyslipidemia, our STRRIDE I Reunion study revealed legacy effects for fitness and cardiometabolic risk factors 10 years following exercise intervention; some of these effects were specific to the amount and intensity of exercise performed. In light of the legacy benefits observed in STRRIDE I, the proposed STRRIDE-PD Reunion study seeks to determine the extent to which changes in fitness and cardiometabolic risk factors acquired in individuals aged 45-75 are maintained over a 10-year period in participants from the STRRIDE-Prediabetes (STRRIDE-PD) randomized trial. Importantly, the STRRIDE-PD Reunion will allow us to verify the observed legacy effects of aerobic exercise training in participants at greater risk for cardiometabolic disease. The STRRIDE-PD trial included a group similar to the lifestyle arm of the Diabetes Prevention Program, designed to achieve weight loss through diet and exercise. This unique design element will allow us to compare the ability of different aerobic exercise interventions – with and without weight loss – to elicit sustained cardiometabolic health benefits in adults with prediabetes. Combined with the previous STRRIDE studies, the STRRIDE-PD Reunion will solidify the scientific knowledge exploring the underlying molecular mechanisms by which exercise – differing in amount, intensity, and mode – produces sustained health benefits across the lifespan from age 45 to 85. Overall, findings from this research will demonstrate the power and value of exercise training programs of even modest duration to elicit long-term cardiometabolic health benefits.

摘要 运动训练产生实质性的健康益处，总结在身体活动指南咨询 委员会报告，并纳入2008年和2018年美国人身体活动指南。 尽管众所周知的好处，太少的人采取运动作为一种健康维护策略。因此，在本发明中， 确定中年时期相对适度的运动训练是否会导致持续的 随着个人进入老年组（遗留效应），健康益处是公共卫生和临床的 重要性在以前久坐不动的超重中年血脂异常成人中，我们的STRRIDE I 团聚研究揭示了运动10年后健身和心脏代谢风险因素的遗留效应 干预;其中一些影响是特定的运动量和强度。鉴于 在STRRIDE I中观察到的遗留受益，拟定的STRRIDE-PD团聚研究旨在确定 在45-75岁的个体中获得的健康和心脏代谢危险因素的变化程度， 在来自随机化的STRRIDE-前驱糖尿病（STRRIDE-PD）受试者中维持10年以上 审判重要的是，STRRIDE-PD团聚将使我们能够验证观察到的有氧运动的遗留效应。 在心脏代谢疾病风险较高的参与者中进行运动训练。STRRIDE-PD试验包括 类似于糖尿病预防计划的生活方式部门，旨在通过 饮食和锻炼。这种独特的设计元素将使我们能够比较不同的有氧运动的能力 干预措施-有和没有体重减轻-在成人中引起持续的心脏代谢健康益处， 糖尿病前期结合之前的STRRIDE研究，STRRIDE-PD团聚将巩固 科学知识探索运动的潜在分子机制-不同的数量， 强度和模式-在45岁至85岁的整个生命周期内产生持续的健康益处。总的来说， 这项研究的结果将证明即使是适度的运动训练计划的力量和价值。 持续时间，以获得长期的心脏代谢健康益处。