Exercise-induced Legacy Health Benefits on Cardiometabolic Risk Factors in Aging Adults with Prediabetes

运动对患有前驱糖尿病的老年人的心脏代谢危险因素的传统健康益处

• 批准号: 10353779
• 负责人: WILLIAM E KRAUS
• 金额: $ 20.13万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-02-01 至 2023-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10353779
• 关键词: Address; Adopted; Adult; Advisory Committees; Aerobic; Aerobic Exercise; Age; Aging; American; Amino Acids; Attenuated; Automobile Driving; Back; Blood specimen; Body Weight decreased; Cardiometabolic Disease; Cardiopulmonary; Chronic Disease; Clinical; Data; Diet; Dyslipidemias; Elderly; Elements; Exercise; Exercise Test; Fasting; Fatty Acids; Follow-Up Studies; Foundations; Glycine; Goals; Guidelines; Health; Health Benefit; Individual; Insulin; Intervention; Investigation; Knowledge; Lead; Life Expectancy; Life Style; Light; Lipids; Lipoproteins; Longevity; Maintenance; Mediating; Medicine; Metabolic; Molecular; Older Population; Outcome; Overweight; Participant; Pathway interactions; Physical activity; Physiological; Plasma; Prediabetes syndrome; Proline; Protocols documentation; Public Health; Reporting; Research; Risk; Risk Factors; Risk Reduction; Supervision; Time; Training Programs; acquired factor; acylcarnitine; age group; age related; aged; arm; blood lipid; burden of illness; cardiometabolic risk; cardiometabolism; cardiorespiratory fitness; design; diabetes prevention program; diet and exercise; disability; exercise intensity; exercise intervention; exercise training; fatty acid oxidation; fitness; follow-up; metabolomics; middle age; novel; peripheral blood; randomized trial; resilience; sedentary; vigorous intensity

Abstract Exercise training produces substantial health benefits, summarized in the Physical Activity Guidelines Advisory Committee Report and incorporated into the 2008 and 2018 Physical Activity Guidelines for Americans. Despite the well-known benefits, too few individuals adopt exercise as a health maintenance strategy. Thus, determining whether a relatively modest duration of exercise training in middle age can lead to sustained health benefits as individuals progress into older age groups (legacy effects) is of public health and clinical importance. In previously sedentary, overweight middle-aged adults with dyslipidemia, our STRRIDE I Reunion study revealed legacy effects for fitness and cardiometabolic risk factors 10 years following exercise intervention; some of these effects were specific to the amount and intensity of exercise performed. In light of the legacy benefits observed in STRRIDE I, the proposed STRRIDE-PD Reunion study seeks to determine the extent to which changes in fitness and cardiometabolic risk factors acquired in individuals aged 45-75 are maintained over a 10-year period in participants from the STRRIDE-Prediabetes (STRRIDE-PD) randomized trial. Importantly, the STRRIDE-PD Reunion will allow us to verify the observed legacy effects of aerobic exercise training in participants at greater risk for cardiometabolic disease. The STRRIDE-PD trial included a group similar to the lifestyle arm of the Diabetes Prevention Program, designed to achieve weight loss through diet and exercise. This unique design element will allow us to compare the ability of different aerobic exercise interventions – with and without weight loss – to elicit sustained cardiometabolic health benefits in adults with prediabetes. Combined with the previous STRRIDE studies, the STRRIDE-PD Reunion will solidify the scientific knowledge exploring the underlying molecular mechanisms by which exercise – differing in amount, intensity, and mode – produces sustained health benefits across the lifespan from age 45 to 85. Overall, findings from this research will demonstrate the power and value of exercise training programs of even modest duration to elicit long-term cardiometabolic health benefits.

摘要 运动训练对健康有很大的好处，体力活动指南咨询中总结了这一点 委员会的报告，并纳入了2008年和2018年美国人的体力活动指南。 尽管锻炼的好处众所周知，但将锻炼作为一种健康维护策略的人太少了。因此， 确定中年相对适度的运动训练是否可以导致持续的 个人进入老年群体时的健康益处(遗留影响)是公共卫生和临床的 重要性。在以前久坐不动、超重的中年血脂异常的成年人中，我们的STRIDE I 留尼汪岛研究显示，运动10年后，健身和心脏代谢风险因素的遗留影响 干预；其中一些影响是与所进行的运动量和强度有关的。根据…… 在STRRIDE I中观察到的遗留好处，拟议的STRRIDE-PD留尼汪岛研究试图确定 45-75岁人群获得的健康和心脏代谢危险因素的变化程度 随机选择STRRIDE-糖尿病前期(STRRIDE-PD)的参与者进行为期10年的维持 审判。重要的是，STRRIDE-PD重聚将使我们能够验证所观察到的有氧运动的遗留影响 运动训练的参与者患心脏代谢性疾病的风险更高。STRRIDE-PD试验包括一项 类似于糖尿病预防计划的生活方式部门，旨在通过以下方式实现减肥 节食和锻炼。这一独特的设计元素将使我们能够比较不同有氧运动的能力 干预措施--减肥和不减肥--为患有以下疾病的成年人带来持续的心脏代谢健康益处 糖尿病前期。结合以前的STRRIDE研究，STRRIDE-PD留尼汪岛将巩固 探索运动潜在分子机制的科学知识--运动量不同， 强度和模式-在45岁至85岁的生命周期内产生持续的健康益处。总的来说， 这项研究的发现将证明运动训练计划的力量和价值，即使是适度的 获得长期心脏代谢健康益处的持续时间。