Exercise-induced Legacy Health Benefits on Cardiometabolic Risk Factors in Aging Adults with Prediabetes

运动对患有前驱糖尿病的老年人的心脏代谢危险因素的传统健康益处

• 批准号: 10656111
• 负责人: WILLIAM E KRAUS
• 金额: $ 16.03万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-02-01 至 2023-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10656111
• 关键词: Address; Administrative Supplement; Adopted; Adult; Advisory Committees; Aerobic Exercise; Age; Aging; American; Amino Acids; Behavior; Biological; Blood Pressure; Blood specimen; Body Weight; Chronic Disease; Clinical; Communities; Coronary heart disease; Data; Development; Disease; Elderly; Exercise; Follow-Up Studies; Funding; Gender; Goals; Guidelines; Health; Health Benefit; Health Status; Heart; Home; Individual; Insulin; Intervention; Lead; Life Expectancy; Light; Lipoproteins; Longevity; Maintenance; Medical History; Medicine; Metabolic; Molecular; Older Population; Parents; Participant; Pathway interactions; Personal Satisfaction; Physical activity; Population; Prediabetes syndrome; Psychology; Public Health; Reporting; Research; Respondent; Risk; Risk Factors; Sampling; Self-Direction; Spouses; Supervision; Training Programs; acylcarnitine; age group; age related; base; blood lipid; burden of illness; cardiometabolic risk; cardiometabolism; cardiorespiratory fitness; cohort; disability; exercise intervention; exercise regimen; exercise training; fitness; heart disease risk; insight; member; metabolomics; middle age; novel; parent project; peripheral blood; psychologic; randomized trial; resilience

Abstract Exercise training produces substantial health benefits, summarized in the Physical Activity Guidelines Advisory Committee Report and incorporated into the 2008 and 2018 Physical Activity Guidelines for Americans. Despite the well-known benefits, too few individuals adopt exercise as a health maintenance strategy. Thus, determining whether a relatively modest duration of exercise training in middle age can lead to sustained health benefits as individuals progress into older age groups (legacy effects) is of public health and clinical importance. As the parent R21 seeks to determine whether a relatively short six-month exercise intervention (STRRIDE-PD) produces sustained, legacy health effects ten years later, this proposed supplement will simultaneously investigate in a community-based cohort (UNC Alumni Heart Study; UNCAHS) whether self- directed exercise behavior is also related to long-term health status. Thus, the proposed supplement will enhance the significance of the parent R21 by extending the generalizability of the findings to individuals who would not have qualified for the STRRIDE studies due to either their risk factor or medical history status. Matched to the STRRIDE-PD Reunion cohort, 200 age- and gender-matched participants from the UNCAHS who have reported on their unsupervised exercise behavior will be invited to complete parallel assessments of cardiorespiratory fitness and cardiometabolic risk factors. Integrating the UNCAHS via the supplement will allow us to compare the legacy effects of supervised exercise training programs to self-directed exercise in a community-based cohort. Taken together, the parent R21 and the proposed supplement will provide unique insight into the biological and psychological underpinnings of physical activity behavior in midlife and long-term cardiometabolic health status.

摘要 运动训练对健康有很大的好处，体力活动指南咨询中总结了这一点 委员会的报告，并纳入了2008年和2018年美国人的体力活动指南。 尽管锻炼的好处众所周知，但将锻炼作为一种健康维护策略的人太少了。因此， 确定中年相对适度的运动训练是否可以导致持续的 个人进入老年群体时的健康益处(遗留影响)是公共卫生和临床的 重要性。因为家长R21试图确定相对较短的六个月运动干预 (STRRIDE-PD)十年后产生持续的、遗留的健康影响，这项拟议的补充方案将 同时在社区队列中调查(北卡罗来纳大学校友心脏研究；UNCAHS)是否自我 定向运动行为也与长期的健康状况有关。因此，拟议的补编将 通过将研究结果的普适性扩展到符合以下条件的个人，增强亲本R21的重要性 由于他们的风险因素或病史状况，不符合STRRIDE研究的条件。 与STRRIDE-PD团聚队列匹配，来自UNCAHS的200名年龄和性别匹配的参与者 那些报告了他们无人监督的锻炼行为的人将被邀请完成对 心肺适能和心脏代谢危险因素。通过补编将UNCAHS整合起来将 允许我们将有监督的运动训练计划的遗留效果与自我指导的运动在 以社区为基础的队列。总而言之，母公司R21和拟议的补充方案将提供独特的 洞察中长期体力活动行为的生理和心理基础 心脏代谢健康状况。