Exercise-induced Legacy Health Benefits on Cardiometabolic Risk Factors in Aging Adults with Prediabetes

运动对患有前驱糖尿病的老年人的心脏代谢危险因素的传统健康益处

• 批准号: 10656111
• 负责人: WILLIAM E KRAUS
• 金额: $ 16.03万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-02-01 至 2023-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10656111
• 关键词: Address; Administrative Supplement; Adopted; Adult; Advisory Committees; Aerobic Exercise; Age; Aging; American; Amino Acids; Behavior; Biological; Blood Pressure; Blood specimen; Body Weight; Chronic Disease; Clinical; Communities; Coronary heart disease; Data; Development; Disease; Elderly; Exercise; Follow-Up Studies; Funding; Gender; Goals; Guidelines; Health; Health Benefit; Health Status; Heart; Home; Individual; Insulin; Intervention; Lead; Life Expectancy; Light; Lipoproteins; Longevity; Maintenance; Medical History; Medicine; Metabolic; Molecular; Older Population; Parents; Participant; Pathway interactions; Personal Satisfaction; Physical activity; Population; Prediabetes syndrome; Psychology; Public Health; Reporting; Research; Respondent; Risk; Risk Factors; Sampling; Self-Direction; Spouses; Supervision; Training Programs; acylcarnitine; age group; age related; base; blood lipid; burden of illness; cardiometabolic risk; cardiometabolism; cardiorespiratory fitness; cohort; disability; exercise intervention; exercise regimen; exercise training; fitness; heart disease risk; insight; member; metabolomics; middle age; novel; parent project; peripheral blood; psychologic; randomized trial; resilience

Abstract Exercise training produces substantial health benefits, summarized in the Physical Activity Guidelines Advisory Committee Report and incorporated into the 2008 and 2018 Physical Activity Guidelines for Americans. Despite the well-known benefits, too few individuals adopt exercise as a health maintenance strategy. Thus, determining whether a relatively modest duration of exercise training in middle age can lead to sustained health benefits as individuals progress into older age groups (legacy effects) is of public health and clinical importance. As the parent R21 seeks to determine whether a relatively short six-month exercise intervention (STRRIDE-PD) produces sustained, legacy health effects ten years later, this proposed supplement will simultaneously investigate in a community-based cohort (UNC Alumni Heart Study; UNCAHS) whether self- directed exercise behavior is also related to long-term health status. Thus, the proposed supplement will enhance the significance of the parent R21 by extending the generalizability of the findings to individuals who would not have qualified for the STRRIDE studies due to either their risk factor or medical history status. Matched to the STRRIDE-PD Reunion cohort, 200 age- and gender-matched participants from the UNCAHS who have reported on their unsupervised exercise behavior will be invited to complete parallel assessments of cardiorespiratory fitness and cardiometabolic risk factors. Integrating the UNCAHS via the supplement will allow us to compare the legacy effects of supervised exercise training programs to self-directed exercise in a community-based cohort. Taken together, the parent R21 and the proposed supplement will provide unique insight into the biological and psychological underpinnings of physical activity behavior in midlife and long-term cardiometabolic health status.

抽象的 《体育活动指南建议》中总结了运动训练可带来巨大的健康益处 委员会报告并纳入 2008 年和 2018 年美国人身体活动指南。 尽管锻炼的好处众所周知，但很少有人将锻炼作为一种健康维护策略。因此， 确定中年时期相对适度的运动训练是否可以带来持续的效果 随着个人进入老年群体（遗留效应），健康益处具有公共卫生和临床意义 重要性。作为家长，R21 试图确定相对较短的六个月运动干预是否有效 （STRRIDE-PD）在十年后产生持续的遗留健康影响，该拟议的补充剂将 同时在基于社区的队列中进行调查（北卡罗来纳大学校友心脏研究；UNCAHS）是否自我 定向运动行为也与长期健康状况有关。因此，拟议的补充将 通过将研究结果的普遍性扩展到以下个体，增强了父 R21 的重要性 由于其风险因素或病史状况，不具备参加 STRRIDE 研究的资格。 来自 UNCAHS 的 200 名年龄和性别匹配的参与者与 STRRIDE-PD Reunion 队列相匹配 报告了其无监督锻炼行为的人将被邀请完成对 心肺健康和心脏代谢危险因素。通过补充内容整合 UNCAHS 将 让我们能够比较监督运动训练计划与自我指导运动的遗留影响 以社区为基础的队列。总而言之，母版 R21 和拟议的补充品将提供独特的 深入了解中年和长期身体活动行为的生物和心理基础 心脏代谢健康状况。