权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Exercise-induced Legacy Health Benefits on Cardiometabolic Risk Factors in Aging Adults with Prediabetes

运动对患有前驱糖尿病的老年人的心脏代谢危险因素的传统健康益处

基本信息

批准号：
10656111
负责人：
WILLIAM E KRAUS
金额：
$ 16.03万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-02-01 至 2023-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10656111
关键词：
Address Administrative Supplement Adopted Adult Advisory Committees Aerobic Exercise Age Aging American Amino Acids Behavior Biological Blood Pressure Blood specimen Body Weight Chronic Disease Clinical Communities Coronary heart disease Data Development Disease Elderly Exercise Follow-Up Studies Funding Gender Goals Guidelines Health Health Benefit Health Status Heart Home Individual Insulin Intervention Lead Life Expectancy Light Lipoproteins Longevity Maintenance Medical History Medicine Metabolic Molecular Older Population Parents Participant Pathway interactions Personal Satisfaction Physical activity Population Prediabetes syndrome Psychology Public Health Reporting Research Respondent Risk Risk Factors Sampling Self-Direction Spouses Supervision Training Programs acylcarnitine age group age related base blood lipid burden of illness cardiometabolic risk cardiometabolism cardiorespiratory fitness cohort disability exercise intervention exercise regimen exercise training fitness heart disease risk insight member metabolomics middle age novel parent project peripheral blood psychologic randomized trial resilience

项目摘要

Abstract Exercise training produces substantial health benefits, summarized in the Physical Activity Guidelines Advisory Committee Report and incorporated into the 2008 and 2018 Physical Activity Guidelines for Americans. Despite the well-known benefits, too few individuals adopt exercise as a health maintenance strategy. Thus, determining whether a relatively modest duration of exercise training in middle age can lead to sustained health benefits as individuals progress into older age groups (legacy effects) is of public health and clinical importance. As the parent R21 seeks to determine whether a relatively short six-month exercise intervention (STRRIDE-PD) produces sustained, legacy health effects ten years later, this proposed supplement will simultaneously investigate in a community-based cohort (UNC Alumni Heart Study; UNCAHS) whether self- directed exercise behavior is also related to long-term health status. Thus, the proposed supplement will enhance the significance of the parent R21 by extending the generalizability of the findings to individuals who would not have qualified for the STRRIDE studies due to either their risk factor or medical history status. Matched to the STRRIDE-PD Reunion cohort, 200 age- and gender-matched participants from the UNCAHS who have reported on their unsupervised exercise behavior will be invited to complete parallel assessments of cardiorespiratory fitness and cardiometabolic risk factors. Integrating the UNCAHS via the supplement will allow us to compare the legacy effects of supervised exercise training programs to self-directed exercise in a community-based cohort. Taken together, the parent R21 and the proposed supplement will provide unique insight into the biological and psychological underpinnings of physical activity behavior in midlife and long-term cardiometabolic health status.

摘要