Beyond theta: analyzing oscillations across the frequency spectrum in patients with dystonia implanted with sensing-enabled pulse generators
超越 theta:分析植入传感脉冲发生器的肌张力障碍患者的整个频谱振荡
基本信息
- 批准号:10569467
- 负责人:
- 金额:$ 6.91万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-05-01 至 2026-04-30
- 项目状态:未结题
- 来源:
- 关键词:AccelerationAccelerometerAlgorithmsBasal GangliaBehaviorBehavioralBiological MarkersBrainChronicClinicComplexDataData CollectionDeep Brain StimulationDevelopmentDevicesDiseaseDyskinetic syndromeDystoniaElectric StimulationElectrodesElectrophysiology (science)FrequenciesFunctional disorderGangliaGenerationsGlobus PallidusGoalsHomeHumanImplantImplanted ElectrodesLabelLeadMonitorMotorMotor CortexMovementMovement DisordersMuscleNeurologicPathologicPatientsPerioperativePhysiologic pulsePhysiologyPostureProcessQuality of lifeResearchSeveritiesSignal TransductionSiteStructureSymptomsTechniquescommercializationimprovedinnovationinsightkinematicsmachine learning methodmotor symptommultimodal datamultimodalitynervous system disorderneuralneuroregulationnext generationnovelpotential biomarkerprogramssupervised learningsymptomatic improvementwearable device
项目摘要
Project Summary/Abstract
Dystonia is a disabling neurological condition characterized by sustained or repetitive muscle movements
causing abnormal movements or postures. Studies that have investigated local field potentials (LFPs) recorded
from deep brain stimulation (DBS) – direct electrical stimulation of subcortical brain structures using chronically
implanted electrodes – leads in dystonia patients have been in-clinic or perioperative recordings while the patient
was performing constrained movements. These studies have characterized pathologically increased low-
frequency activity [i.e., theta (3-8 Hz)] and its relationship to dystonic symptoms. However, the functional
relevance of this activity remains elusive and recent findings have implicated that additional oscillations (e.g.,
finely-tuned or narrowband gamma) may be related to pathophysiology. The objective of this application is to
identify individualized LFP biomarkers of dystonia in a data-driven manner across the basal ganglia and cortex,
while revealing the relationship between fluctuations in biomarkers to symptom suppression during DBS. We will
accomplish this using a second-generation investigational, bidirectional device (Medtronic RC+S), which allows
us to chronically sense LFPs and deliver DBS therapy while patients are in at-home settings. These novel
recordings and devices provide insights into complex biomarkers and naturalistic behaviors, allowing a direct
comparison of individualized biomarkers to symptom monitoring or suppression. This will advance our
understanding of neural changes associated with dystonia and DBS, ultimately improving current
neurostimulation therapy. Our central hypothesis is that naturalistic neural recordings, specifically those
recorded both cortically and subcortically in conjunction with multimodal signal acquisition (i.e., video kinematics
and acceleration), can detect personalized biomarkers of dystonic symptoms that can illuminate our network
understanding of the disease and its symptom manifestation, while aiding in the optimization of DBS therapy. In
Aim 1, we will identify and characterize individualized power bands associated with pathological activity in
patients with dystonia using chronic subcortical and cortical recordings. We will decode pathological states using
supervised and self-supervised machine learning techniques. In Aim 2, we will determine personalized power
bands modulated during deep brain stimulation in patients with dystonia using chronic subcortical and cortical
recordings and utilize these relationships to optimize stimulation programming. This research is significant and
innovative because it will be the first chronic, multisite LFP recording paradigm to study effects of dystonic
symptoms and DBS on pallidal LFPs, cortical LFPs, and subcortical-cortical interactions using the Medtronic
RC+S, providing ample information about basal ganglia and cortical functions, network interactions in dystonia
and the mechanisms of DBS. Lastly, our goal is to expand this paradigm into commercialized, sensing-enabled
DBS devices – the preliminary steps towards personalized neuromodulation.
项目总结/文摘
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Stephanie Lynn Cernera其他文献
Stephanie Lynn Cernera的其他文献
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{{ truncateString('Stephanie Lynn Cernera', 18)}}的其他基金
Wearable-Sensor Driven Responsive Deep Brain Stimulation for the Improved Treatment of Essential Tremor
可穿戴传感器驱动的响应性深部脑刺激可改善特发性震颤的治疗
- 批准号:
10160652 - 财政年份:2020
- 资助金额:
$ 6.91万 - 项目类别:
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