Tracking Depression and Associated Modifiable Social-Emotional Factors in Adolescent Girls with Autism

追踪自闭症少女的抑郁症和相关的可改变的社会情感因素

• 批准号: 10572498
• 负责人: Shuting Zheng
• 金额: $ 11.75万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-12-09 至 2024-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10572498
• 关键词: Acceleration; Adolescence; Adolescent; Age; Behavioral; Characteristics; Clinical; Coping Skills; Data; Data Analyses; Data Collection; Development; Diagnosis; Ecological momentary assessment; Emotional; Emotions; Ensure; Equation; Female; Female Adolescents; Friendships; Goals; Impairment; Individual; Institution; Intervention; Learning; Life; Loneliness; Longitudinal Studies; Maps; Measurement; Measures; Mental Depression; Mental Health; Mental disorders; Mentors; Methodology; Methods; Modeling; Mood Disorders; Moods; Motivation; National Institute of Mental Health; Pattern; Phase; Population; Positioning Attribute; Prevention; Prevention strategy; Protocols documentation; Psychological Impact; Psychopathology; Reporting; Research; Research Activity; Research Personnel; Resources; Risk; Risk Factors; Sampling; Social Interaction; Strategic Planning; Symptoms; Techniques; Time; Training; Training Activity; Vulnerable Populations; Well in self; adolescent with autism spectrum disorder; autism spectrum disorder; boys; completed suicide; depression prevention; depressive symptoms; design; early adolescence; effective intervention; emotion regulation; emotional experience; emotional factor; experience; girls; high risk; individualized medicine; individuals with autism spectrum disorder; interest; male; mood symptom; negative mood; novel; peer victimization; programs; protective factors; psychosocial; sex; skills; social; social relationships; success; therapy development; treatment strategy

PROJECT SUMMARY/ABSTRACT Adolescent girls with autism spectrum disorder (ASD) are at high risk for depression due to risk factors associated with female sex and ASD-related challenges. However, little empirical evidence is available on the psychosocial mechanisms of depression onset and change for girls with ASD, leaving no effective intervention to treat depression in this extremely vulnerable group. While social interaction and relationship challenges are particularly pronounced during adolescence, sufficiently nuanced longitudinal data is needed to understand how momentary and cumulative social and emotional experiences impact psychological well-being during this critical time in order to inform treatment development. The current proposal aims to investigate longitudinal trajectories and social mechanisms of depression in ASD during adolescence with a focus on girls. Three complementary studies are proposed to achieve the research objectives and provide necessary training to equip the candidate with advanced methodological and professional skills to transition into an independent research position. During the mentored K99 phase, two secondary data analyses will leverage existing data to generate initial evidence on depression and social experience in adolescent girls with ASD to: (1) Map trajectories of depression symptoms in girls with ASD and typical development (age 10 to 13) (Aim 1), using group-based longitudinal structural equation models (LSEM); (2) Profile daily social experiences relevant to negative mood and depressive symptoms in girls with ASD (Aim 2), using daily social experiences data collected with a cross-sectional sample of transition-age youths with ASD. To examine social-emotional protective and risk factors of depression (Aim 3), during the R00 phase, an accelerated longitudinal study with measurement bursts using ecological momentary sampling (EMA, study protocol piloted in K99) will be conducted to collect four waves of original data on 120 adolescent girls (60 ASD and 60 TD, age 14 to 16) over two years. Findings from the novel multi-method longitudinal study will directly inform development of targeted intervention by identifying how momentary social experiences, emotions, and coping strategies impact mood in the “moment” and in the long term, while considering the impact of individual- level characteristics. Through the carefully designed training activities and the institutional resources available at UCSF, the candidate will receive focused training on developmental psychopathology and pubertal development in ASD, hands-on clinical experiences in identifying and treating depression in girls with ASD, and methodological training in the state-of-art design and analyses of EMA during the K99 phase. With the strong support from a team of leading experts in their respective fields, the candidate will successfully establish her own line of research and become an independent researcher with unique expertise.

项目总结/摘要 患有自闭症谱系障碍（ASD）的青春期女孩由于危险因素而处于抑郁症的高风险中 与女性性和自闭症相关的挑战。然而，很少有经验证据表明， ASD女孩抑郁发作和变化的心理社会机制，没有有效的干预措施 来治疗这个极度脆弱群体的抑郁症虽然社交互动和关系挑战 特别是在青春期，需要足够细致的纵向数据来了解如何 短暂和累积的社会和情感经历会影响心理健康， 时间，以便了解治疗进展。 目前的建议旨在调查自闭症抑郁症的纵向轨迹和社会机制 在青春期，重点是女孩。三个互补的研究建议，以实现研究 目标，并提供必要的培训，使候选人具备先进的方法和专业知识 转变为独立研究职位的技能。在K99辅导阶段， 分析将利用现有的数据来产生关于抑郁症和社会经验的初步证据， ASD的青春期女孩：（1）绘制ASD女孩和典型的抑郁症状的轨迹 发展（10至13岁）（目标1），使用基于组的纵向结构方程模型（LSEM）;（2） 描述ASD女孩与消极情绪和抑郁症状相关的日常社会经历（目标2）， 使用日常社会经验的数据收集了一个横截面样本的过渡年龄的青少年与ASD。 为了研究抑郁症的社会-情绪保护因素和危险因素（目标3），在R 00阶段， 使用生态瞬时抽样的测量突发的加速纵向研究（EMA，研究 在K99试验的协议）将进行收集120个青春期女孩（60 ASD）的原始数据的四波 和60 TD，年龄14至16岁）。新的多方法纵向研究的结果将直接 通过识别瞬间的社会经历、情绪和 应对策略在“当下”和长期影响情绪，同时考虑到个体的影响， 水平特征。 通过精心设计的培训活动和UCSF提供的机构资源， 将接受关于ASD的发展精神病理学和青春期发展的重点培训， 在ASD女孩中识别和治疗抑郁症的临床经验， K99阶段EMA的最新设计和分析。在领导团队的大力支持下， 在各自领域的专家，候选人将成功地建立自己的研究路线，并成为 一位拥有独特专业知识的独立研究员