Reward responsivity and depression in autism spectrum disorder: A multimethod approach

自闭症谱系障碍中的奖励反应和抑郁：多种方法

• 批准号: 10571567
• 负责人: Jessica M Schwartzman
• 金额: $ 16.04万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-12-01 至 2023-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10571567
• 关键词: 17 year old; Adolescence; Adolescent; Adult; Behavioral; Biological Markers; Clinical; Complex; Development; Development Plans; Developmental Course; Diagnostic; Early Diagnosis; Early Intervention; Electroencephalography; Employment; Event-Related Potentials; Face; Family member; Future; Goals; High Prevalence; Impairment; Intervention; Interview; Investigation; Knowledge; Literature; Maintenance; Measurement; Measures; Mental Depression; Mental disorders; Mentored Patient-Oriented Research Career Development Award; Mentors; Mentorship; Methodology; Methods; Modeling; Mood Disorders; National Institute of Mental Health; Neurobiology; Outcome; Pathway interactions; Population; Positive Valence; Prevalence; Provider; Psychophysiology; Quality of life; Research; Research Domain Criteria; Rewards; Risk; Risk Factors; Sampling; Schedule; Schizophrenia; Schools; Severities; Social Interaction; Social Processes; Strategic Planning; Symptoms; Techniques; Testing; Time; Training; Translating; Translational Research; Vulnerable Populations; Work; adolescent with autism spectrum disorder; autism spectrum disorder; career; career development; child depression; clinical translation; depressive symptoms; emotional experience; experience; follow-up; high risk; longitudinal analysis; longitudinal design; method development; mortality risk; neural; neurophysiology; novel; peer; physical conditioning; premature; prospective; recruit; response; screening; social; social communication; suicidal morbidity; symptomatology; therapy development

PROJECT SUMMARY Adolescents with Autism Spectrum Disorder experience depression at rates nearly twice that of their neurotypical peers (20% vs. 11%). Untreated depression is associated with adverse short (e.g., school refusal) and long-term outcomes (e.g., poor physical health, lower employment) that impair quality of life. Adolescents with autism also face a 10x increase in the risk for premature death by suicide than their neurotypical peers. Risk factors to depression in autism are not well understood and measurement efforts may be complicated by social communication difficulties (i.e., autism symptomatology) that complicate adolescents’ efforts to identify and explain emotional experiences to providers and family members. Therefore, more objective measures (e.g., electroencephalogram [EEG], specifically event-related potentials [ERPs]) may provide a better understanding of risk factors to depression in adolescents with autism. Altered reward responsivity (Research Domain Criteria [RDoC] Positive Valence) and disrupted social processes (RDoC Affiliation and Attachment) are key risk factors to depression for neurotypical adolescents, but have not been investigated in autism. Clinical and neural measures of social and nonsocial reward responsivity and associations with depression symptoms have not been examined in autism, which may provide meaningful information about developmental trajectories. Consistent with the NIMH Strategic Plan, Strategic Goal 2, “to identify and understand risk factors, biomarkers and behavioral indicators of mental illness,” this K23 application aims to examine clinical and neural markers of social and nonsocial reward responsivity and associations with depression symptoms in adolescents with autism, including longitudinal investigations. Under the mentorship of a diverse team of experts in autism, depression, reward responsivity, psychophysiological methods, and longitudinal and statistical methodologies, this proposal will examine the predictive influences of these RDoC constructs to depression in adolescents 14-17 years old with autism. Adolescence is a key developmental period for early detection and intervention as it is characterized by spikes in depression prevalence and an increasing importance of peer relationships. Specifically, this proposal will use EEG/ERP techniques and clinician-rated interviews to measure social and nonsocial reward responsivity in adolescents with autism and test relationships with depression symptoms. Adolescents will be assessed one year later to investigate how clinical and neural measures predict depression symptoms over time, which will inform the developmental course of these RDoC constructs in this vulnerable population. The applicant’s long- term goal is to understand the neurobiological and behavioral development of reward responsivity in autism and associations with depression from adolescence to adulthood so as to inform screening methods and intervention development. Mentored training will allow the applicant to gain expertise in multimethod measures (e.g., ERP methodologies, clinician-rated interviews) and longitudinal design and analysis, with an emphasis on assessing mechanisms associated with the onset, maintenance, and treatment of depression in autism.

项目摘要 患有自闭症谱系障碍的青少年经历抑郁症的比率几乎是他们的神经典型性抑郁症的两倍。 同行（20%对11%）。未经治疗的抑郁症与不良短（例如，学校拒绝）和长期 结果（例如，身体健康状况差，就业率低），影响生活质量。患有自闭症的青少年 面临着10倍的风险过早死亡的自杀比他们的神经正常的同龄人。的危险因素 自闭症中的抑郁症还没有得到很好的理解，测量工作可能会因社会因素而复杂化。 通信困难（即，孤独症诊断学），使青少年识别和 向提供者和家庭成员解释情感经历。因此，更客观的措施（例如， 脑电图[EEG]，特别是事件相关电位[ERPs]）可以提供更好的理解 自闭症青少年抑郁症的危险因素。改变的奖励响应度（研究领域标准 [RDoC]正效价）和中断的社会过程（RDoC归属感和依恋）是关键的风险因素 抑郁症的神经典型的青少年，但尚未调查自闭症。临床和神经 社会和非社会奖励反应性的测量以及与抑郁症状的关联， 在自闭症中进行了检查，这可能会提供有关发展轨迹的有意义的信息。 与NIMH战略计划，战略目标2一致，“识别和了解风险因素，生物标志物， 和精神疾病的行为指标，”这个K23应用程序的目的是检查临床和神经标志物， 孤独症青少年的社会和非社会奖励反应性及其与抑郁症状的关系， 包括纵向调查。在自闭症、抑郁症、 奖励响应性，心理生理学方法，纵向和统计方法，这一建议 将研究这些RDoC结构对14-17岁青少年抑郁症的预测影响 患有自闭症青春期是早期发现和干预的关键发育期，因为它的特点是 抑郁症患病率的激增和同伴关系的重要性日益增加。具体而言，这项提案 将使用EEG/ERP技术和临床医生评定的访谈来测量社会和非社会奖励反应性 在青少年自闭症和测试与抑郁症状的关系。青少年将被评估为1 一年后，研究临床和神经指标如何预测抑郁症症状，这将 告知这些RDoC结构在这个弱势群体中的发展过程。申请人的长期- 长期目标是了解自闭症患者奖励反应的神经生物学和行为发展， 从青春期到成年期与抑郁症的关联，以便为筛查方法和干预提供信息 发展指导培训将使申请人获得多方法测量方面的专业知识（例如，ERP 方法，临床医生评定的访谈）和纵向设计和分析，重点是评估 与自闭症抑郁症的发病、维持和治疗相关的机制。