Delineating impacts of gestational opioid exposure on central swallow networks.

描述妊娠期阿片类药物暴露对中枢吞咽网络的影响。

基本信息

  • 批准号:
    10573422
  • 负责人:
  • 金额:
    $ 23.48万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-01-01 至 2024-12-31
  • 项目状态:
    已结题

项目摘要

The ability coordinate breathing, suckling, and swallow is required for survival at birth. Infants with prenatal exposure to opioids can have abnormalities in swallow efficiency and swallow-breathing coordination, sensory- motor responses to pharyngeal stimulus, and esophageal motility reflexes, which often results in persistent feeding difficulties. The swallow pattern generator is located within the brainstem, but it has been difficult to study due to its location and widely dispersed neural circuits. Our preliminary studies describe a novel method that allows for the visualization and recording of a vast number of neurons along the intermediate zone of the medial reticular formation and Nucleus Ambiguus (NA), while preserving the Nucleus Tractus Solitarius. We demonstrate reliable central stimulation of swallow with simultaneous optical recording of neurons in the semicompact and compact regions of the NA, along with nerve root recordings. Activation of NA neurons during swallow is affected by prenatal opioid exposure. Our methods also allow superimposition of optical recordings onto subsequent immunohistochemical images to identify regional cellular phenotypes and to confirm recording locations. Our working hypothesis is that the brainstem swallow network spans the medulla and is vulnerable to opioids. The current application has evolved from collaborative work from two established investigators, bringing together expertise in central neural circuitry, optical/ histological techniques, and regulation of swallow. The proposed studies are designed to describe location and type of neurons active during swallow, alterations when swallow is stimulated across the respiratory cycle, and the impact of neonatal opioid withdrawal syndrome. The combined state-of-the-art techniques will provide much-needed mechanistic insight into swallow and clinical observation of infants with neonatal opioid withdrawal syndrome (NOWS).
协调呼吸、哺乳和吞咽的能力是出生时生存所必需的。产前婴儿

项目成果

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NICHOLAS M MELLEN其他文献

NICHOLAS M MELLEN的其他文献

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{{ truncateString('NICHOLAS M MELLEN', 18)}}的其他基金

Network mechanisms for respiratory rhythm generation
呼吸节律产生的网络机制
  • 批准号:
    6822022
  • 财政年份:
    2001
  • 资助金额:
    $ 23.48万
  • 项目类别:
Network mechanisms for respiratory rhythm generation
呼吸节律产生的网络机制
  • 批准号:
    7435192
  • 财政年份:
    2001
  • 资助金额:
    $ 23.48万
  • 项目类别:
Respiratory Reflexes In Vitro
体外呼吸反射
  • 批准号:
    6364172
  • 财政年份:
    2001
  • 资助金额:
    $ 23.48万
  • 项目类别:
Network mechanisms for respiratory rhythm generation
呼吸节律产生的网络机制
  • 批准号:
    7244312
  • 财政年份:
    2001
  • 资助金额:
    $ 23.48万
  • 项目类别:
Respiratory Reflexes In Vitro
体外呼吸反射
  • 批准号:
    6538067
  • 财政年份:
    2001
  • 资助金额:
    $ 23.48万
  • 项目类别:
Network mechanisms for respiratory rhythm generation
呼吸节律产生的网络机制
  • 批准号:
    7067549
  • 财政年份:
    2001
  • 资助金额:
    $ 23.48万
  • 项目类别:
Respiratory Reflexes In Vitro
体外呼吸反射
  • 批准号:
    6638808
  • 财政年份:
    2001
  • 资助金额:
    $ 23.48万
  • 项目类别:
Respiratory Reflexes In Vitro
体外呼吸反射
  • 批准号:
    6952474
  • 财政年份:
    2001
  • 资助金额:
    $ 23.48万
  • 项目类别:
AFFERENT MODULATION OF RESPIRATORY PATTERN IN VITRO
体外呼吸模式的传入调节
  • 批准号:
    2214245
  • 财政年份:
    1996
  • 资助金额:
    $ 23.48万
  • 项目类别:
AFFERENT MODULATION OF RESPIRATORY PATTERN IN VITRO
体外呼吸模式的传入调节
  • 批准号:
    2214244
  • 财政年份:
    1995
  • 资助金额:
    $ 23.48万
  • 项目类别:

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