Respiratory Reflexes In Vitro
体外呼吸反射
基本信息
- 批准号:6364172
- 负责人:
- 金额:$ 19.13万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2001
- 资助国家:美国
- 起止时间:2001-07-01 至 2004-05-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION (Applicant's abstract): To investigate the effect of lung afferent
signals on central respiratory rhythm generating circuits, an in vitroneonate
rat brainstem/spinal cord preparation, retaining the lungs and their vagal
innervation is used. In this preparation, essential rhythm generating circuits
are retained, and can be modulated by selective activation of lung slowly
adapting mechanoreceptors (SAR). In response to physiological pressures, this
in vitropreparation replicates critical aspects of SAR-mediated frequency
modulation obtained in vivo: 1) Lung inflation during expiration (E) prolongs E
and shifts the phase of respiratory rhythm (Breuer-Hering expiratory reflex;
BHE). 2) Lung inflation during inspiration (I) shortens I (Breuer-Hering
inspiratory reflex; BHI). 3) SAR feedback increases respiratory frequency when
lungs are inflated within 1500 ms of I onset. We will: 1) Identify essential
rhythmogenic circuits using SAR modulation as a probe. The BHE is blocked by
GABAA receptor antagonist bicuculline, indicating that CV-mediated inhibition
is necessary for the reflex. Because the respiratory rhythm is reset, neurons
hyperpolarized during mid-expiratory inflation include rhythmogenic neurons.
Neurons excited, unmodulated or weakly hyperpolarized during inflation-induced
expiratory lengthening are relay neurons, or neurons providing modulatory input
to rhythmogenic circuits. This is a critical functional probe to classify
respiratory neurons, which based on their firing patterns and intrinsic
properties, have resisted simple, consistent classification. 2) Characterize
the cellular and synaptic mechanisms for respiratory frequency modulation.
Depending on the stimulus phase, inflation can increase or decrease respiratory
frequency. In addition, response to SAR afferent input has both a fast and a
slow component. Consistent with these observations is the hypothesis that
expiratory lengthening is due to hyperpolarization via a paucisynaptic pathway
of a subset of rhythmogenic inspiratory neurons, while the increase in
frequency accompanying phasic inflation is due to a reorganization of the
respiratory network. We propose experiments to test both components of this
hypothesis. 3) Describe how sensory feedback transforms the network properties
of medullary circuits. At the network level, reincorporating appropriate
sensory feedback dramatically increases respiratory frequency. At the single
neuron level, firing patterns of respiratory-modulated neurons are transformed.
The observed changes shed light on how rhythmogenic circuits in vitro may
function in the intact animal.
描述(申请人摘要):探讨肺传入的作用
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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NICHOLAS M MELLEN其他文献
NICHOLAS M MELLEN的其他文献
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{{ truncateString('NICHOLAS M MELLEN', 18)}}的其他基金
Delineating impacts of gestational opioid exposure on central swallow networks.
描述妊娠期阿片类药物暴露对中枢吞咽网络的影响。
- 批准号:
10573422 - 财政年份:2023
- 资助金额:
$ 19.13万 - 项目类别:
Network mechanisms for respiratory rhythm generation
呼吸节律产生的网络机制
- 批准号:
6822022 - 财政年份:2001
- 资助金额:
$ 19.13万 - 项目类别:
Network mechanisms for respiratory rhythm generation
呼吸节律产生的网络机制
- 批准号:
7435192 - 财政年份:2001
- 资助金额:
$ 19.13万 - 项目类别:
Network mechanisms for respiratory rhythm generation
呼吸节律产生的网络机制
- 批准号:
7244312 - 财政年份:2001
- 资助金额:
$ 19.13万 - 项目类别:
Network mechanisms for respiratory rhythm generation
呼吸节律产生的网络机制
- 批准号:
7067549 - 财政年份:2001
- 资助金额:
$ 19.13万 - 项目类别:
AFFERENT MODULATION OF RESPIRATORY PATTERN IN VITRO
体外呼吸模式的传入调节
- 批准号:
2214245 - 财政年份:1996
- 资助金额:
$ 19.13万 - 项目类别:
AFFERENT MODULATION OF RESPIRATORY PATTERN IN VITRO
体外呼吸模式的传入调节
- 批准号:
2214244 - 财政年份:1995
- 资助金额:
$ 19.13万 - 项目类别:
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