Respiratory Reflexes In Vitro

体外呼吸反射

基本信息

  • 批准号:
    6364172
  • 负责人:
  • 金额:
    $ 19.13万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2001
  • 资助国家:
    美国
  • 起止时间:
    2001-07-01 至 2004-05-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (Applicant's abstract): To investigate the effect of lung afferent signals on central respiratory rhythm generating circuits, an in vitroneonate rat brainstem/spinal cord preparation, retaining the lungs and their vagal innervation is used. In this preparation, essential rhythm generating circuits are retained, and can be modulated by selective activation of lung slowly adapting mechanoreceptors (SAR). In response to physiological pressures, this in vitropreparation replicates critical aspects of SAR-mediated frequency modulation obtained in vivo: 1) Lung inflation during expiration (E) prolongs E and shifts the phase of respiratory rhythm (Breuer-Hering expiratory reflex; BHE). 2) Lung inflation during inspiration (I) shortens I (Breuer-Hering inspiratory reflex; BHI). 3) SAR feedback increases respiratory frequency when lungs are inflated within 1500 ms of I onset. We will: 1) Identify essential rhythmogenic circuits using SAR modulation as a probe. The BHE is blocked by GABAA receptor antagonist bicuculline, indicating that CV-mediated inhibition is necessary for the reflex. Because the respiratory rhythm is reset, neurons hyperpolarized during mid-expiratory inflation include rhythmogenic neurons. Neurons excited, unmodulated or weakly hyperpolarized during inflation-induced expiratory lengthening are relay neurons, or neurons providing modulatory input to rhythmogenic circuits. This is a critical functional probe to classify respiratory neurons, which based on their firing patterns and intrinsic properties, have resisted simple, consistent classification. 2) Characterize the cellular and synaptic mechanisms for respiratory frequency modulation. Depending on the stimulus phase, inflation can increase or decrease respiratory frequency. In addition, response to SAR afferent input has both a fast and a slow component. Consistent with these observations is the hypothesis that expiratory lengthening is due to hyperpolarization via a paucisynaptic pathway of a subset of rhythmogenic inspiratory neurons, while the increase in frequency accompanying phasic inflation is due to a reorganization of the respiratory network. We propose experiments to test both components of this hypothesis. 3) Describe how sensory feedback transforms the network properties of medullary circuits. At the network level, reincorporating appropriate sensory feedback dramatically increases respiratory frequency. At the single neuron level, firing patterns of respiratory-modulated neurons are transformed. The observed changes shed light on how rhythmogenic circuits in vitro may function in the intact animal.
描述(申请人摘要):探讨肺传入的作用

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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NICHOLAS M MELLEN其他文献

NICHOLAS M MELLEN的其他文献

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{{ truncateString('NICHOLAS M MELLEN', 18)}}的其他基金

Delineating impacts of gestational opioid exposure on central swallow networks.
描述妊娠期阿片类药物暴露对中枢吞咽网络的影响。
  • 批准号:
    10573422
  • 财政年份:
    2023
  • 资助金额:
    $ 19.13万
  • 项目类别:
Network mechanisms for respiratory rhythm generation
呼吸节律产生的网络机制
  • 批准号:
    6822022
  • 财政年份:
    2001
  • 资助金额:
    $ 19.13万
  • 项目类别:
Network mechanisms for respiratory rhythm generation
呼吸节律产生的网络机制
  • 批准号:
    7435192
  • 财政年份:
    2001
  • 资助金额:
    $ 19.13万
  • 项目类别:
Network mechanisms for respiratory rhythm generation
呼吸节律产生的网络机制
  • 批准号:
    7244312
  • 财政年份:
    2001
  • 资助金额:
    $ 19.13万
  • 项目类别:
Network mechanisms for respiratory rhythm generation
呼吸节律产生的网络机制
  • 批准号:
    7067549
  • 财政年份:
    2001
  • 资助金额:
    $ 19.13万
  • 项目类别:
Respiratory Reflexes In Vitro
体外呼吸反射
  • 批准号:
    6538067
  • 财政年份:
    2001
  • 资助金额:
    $ 19.13万
  • 项目类别:
Respiratory Reflexes In Vitro
体外呼吸反射
  • 批准号:
    6638808
  • 财政年份:
    2001
  • 资助金额:
    $ 19.13万
  • 项目类别:
Respiratory Reflexes In Vitro
体外呼吸反射
  • 批准号:
    6952474
  • 财政年份:
    2001
  • 资助金额:
    $ 19.13万
  • 项目类别:
AFFERENT MODULATION OF RESPIRATORY PATTERN IN VITRO
体外呼吸模式的传入调节
  • 批准号:
    2214245
  • 财政年份:
    1996
  • 资助金额:
    $ 19.13万
  • 项目类别:
AFFERENT MODULATION OF RESPIRATORY PATTERN IN VITRO
体外呼吸模式的传入调节
  • 批准号:
    2214244
  • 财政年份:
    1995
  • 资助金额:
    $ 19.13万
  • 项目类别:

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  • 批准号:
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  • 批准号:
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