Project 4: Development and validation of Pencil Beam Scanning methodology for particle FLASH radiotherapy

项目摘要 这个项目将使用铅笔束扫描技术来研究闪光辐射的时空传输。 现代铅笔束扫描(PBS)技术可以提供空间非均匀(高斯型)铅笔束 对浅层和深层肿瘤都有很高的瞬时剂量率；然而，低剂量尾 铅笔束和大目标相对较慢的体积扫描速度产生了可变的剂量率 选定的目标或正常组织位置。这种时空变化的影响目前还不清楚 闪电侠。即使在相同的(平均)剂量率下，闪光治疗也存在简并性 通过不同的时间-剂量序列。有必要在以下背景下研究剂量传递的时间结构 闪光治疗，以及测量和记录每个闪光治疗，以便结果可以 更好地理解。我们的中心假设是质子PBS可以被优化以提供闪光增强 利用现有的加速器技术进行放射治疗。这项建议的目的是： 目标1-通过PBS光束研究SOBP与SOBP的时空变化。 目的2-建立PbS闪光的时空生物有效剂量模型 质子疗法。 目标3-发展快速剂量记录仪器、图像引导定位系统、质量 保证程序和端到端验证。 该项目的成功将展示使用质子向大容量处理量提供闪光的能力 这是PBS的第一次。结合质子治疗能够准确地将剂量输送到深层目标的能力， 这将使PBS闪光质子疗法转化为早期临床试验研究。

Project Summary This project will investigate spatio-temporal delivery of FLASH radiation using pencil beam scanning technology. Modern Pencil Beam Scanning (PBS) technology can deliver spatially non-uniform (Gaussian-like) pencil beam in very high instantaneous dose rate to both shallow and deep-seated tumors; however, the low dose tail of a pencil beam and the relatively slow volume scanning speed for large targets generate a variable dose rate at selected target or normal tissue locations. The impact of this spatial-temporal variation is still unknown for FLASH. Even at the same (averaged) dose rate, degeneracy exists that the FLASH treatment can be delivered by different time-dose sequences. There is a need to study the timing structure of dose delivery in the context of FLASH treatment, as well as measuring and documenting each FLASH treatment so that the outcome can be better understood. Our central hypothesis is that proton PBS can be optimized to deliver FLASH enhanced radiotherapy with existing accelerator technology. The aims of the proposal are: Aim 1 - Investigation of spatio-temporal variations and SOBP versus shoot through PBS beams. Aim 2 - Development of a spatial-temporal biological effective dose model for PBS-based FLASH proton therapy. Aim 3 - Development of fast dose recording instrumentation, image guided positional systems, quality assurance procedures, and end-to-end validation. Success of this project will demonstrate the ability to deliver FLASH to large treatment volumes using proton PBS for the first time. Combined with the ability of proton therapy to accurately deliver dose to deep targets, this will allow translation of PBS FLASH proton therapy to early stage clinical trial studies.