Project 4: Development and validation of Pencil Beam Scanning methodology for particle FLASH radiotherapy
Project 4: Development and validation of Pencil Beam Scanning methodology for particle FLASH radiotherapy
批准号:
10573298
负责人:
Rodney Wiersma
金额:
$32.12万
依托单位国家:
美国
项目类别:
财政年份:
2022
资助国家:
美国
项目状态:
未结题
起止时间:
2022-02-15 至 2027-01-31
关键词:
AlgorithmsAnimal ExperimentsAnimalsBiologicalBiological ModelsBiologyBlood capillariesCanis familiarisClinicalComplexComputer softwareDevelopmentDiffusionDoseDose RateEnsureFutureGamma RaysGoalsInvestigationIonsLinear Energy TransferLocationMeasurementMeasuresMethodologyMethodsModelingModernizationMonitorMusNatureNormal tissue morphologyOutcomeOutcome MeasureOutcome StudyOverdoseOxygenPatientsPhase I Clinical TrialsPhysiologic pulsePlug-inPositioning AttributeProceduresProtonsRadiationRadiation therapyRadiobiologyReactive Oxygen SpeciesResearchResolutionRoboticsSafetyScanningSpeedStructureSystemTailTechniquesTechnologyTestingTimeTissuesTranslationsValidationVariantVascular blood supplyVendorbeamlineclinical implementationdesignexperienceexperimental studyimage guidedinstrumentationirradiationparticleparticle beampreclinical studypreventproton therapyquality assurancespatial temporal variationspatiotemporalsuccesstooltranslational studytransmission processtreatment planningtumor
中文摘要
项目总结
英文摘要
Project Summary
This project will investigate spatio-temporal delivery of FLASH radiation using pencil beam scanning technology.
Modern Pencil Beam Scanning (PBS) technology can deliver spatially non-uniform (Gaussian-like) pencil beam
in very high instantaneous dose rate to both shallow and deep-seated tumors; however, the low dose tail of a
pencil beam and the relatively slow volume scanning speed for large targets generate a variable dose rate at
selected target or normal tissue locations. The impact of this spatial-temporal variation is still unknown for
FLASH. Even at the same (averaged) dose rate, degeneracy exists that the FLASH treatment can be delivered
by different time-dose sequences. There is a need to study the timing structure of dose delivery in the context of
FLASH treatment, as well as measuring and documenting each FLASH treatment so that the outcome can be
better understood. Our central hypothesis is that proton PBS can be optimized to deliver FLASH enhanced
radiotherapy with existing accelerator technology. The aims of the proposal are:
Aim 1 - Investigation of spatio-temporal variations and SOBP versus shoot through PBS beams.
Aim 2 - Development of a spatial-temporal biological effective dose model for PBS-based FLASH
proton therapy.
Aim 3 - Development of fast dose recording instrumentation, image guided positional systems, quality
assurance procedures, and end-to-end validation.
Success of this project will demonstrate the ability to deliver FLASH to large treatment volumes using proton
PBS for the first time. Combined with the ability of proton therapy to accurately deliver dose to deep targets,
this will allow translation of PBS FLASH proton therapy to early stage clinical trial studies.
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Project 4: Development and validation of Pencil Beam Scanning methodology for particle FLASH radiotherapy
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依托单位:
海外基金