NMR Technologies for Integrating Structure, Function and Disease
整合结构、功能和疾病的 NMR 技术
基本信息
- 批准号:10573321
- 负责人:
- 金额:$ 113.97万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-01-02 至 2025-12-31
- 项目状态:未结题
- 来源:
- 关键词:3D PrintAccelerationAddressAlgorithmsAmyloidAmyloid FibrilsAntifungal AgentsAreaArecaAutomatic Data ProcessingAutomationAutomobile DrivingBenchmarkingBindingBiologicalBiologyBiomedical ResearchBiomolecular Nuclear Magnetic ResonanceBiotechnologyBlood coagulationCalibrationChadChemicalsChronologyCollaborationsCommunitiesComplexComputer softwareCosts and BenefitsCustomDataData AnalysesData CollectionDedicationsDevelopmentDiameterDiseaseEducational workshopEnsureEnvironmentEnzymesFeedbackFoundationsFree EnergyFundingFutureG-Protein-Coupled ReceptorsGoalsGrantHealthHuman ResourcesIllinoisIn VitroInstructionInvestmentsIonic StrengthsKineticsKnowledgeLearningLewy BodiesLigandsLinuxMagicMeasurementMediationMedicineMembraneMembrane ProteinsMethodsMichiganMicroscopicModelingModernizationMultienzyme ComplexesNMR SpectroscopyNeurodegenerative DisordersNucleic AcidsOperating SystemOutcomePathogenicityPathologyPharmaceutical PreparationsPhysiologicalPreparationProceduresProductivityProteinsProtocols documentationPublishingReportingReproducibilityResearch InfrastructureResolutionResourcesRestRunningSamplingScienceServicesSolidSpecificitySpeedSterolsStructureSurfaceSystemTechnologyTechnology TransferTestingThermodynamicsTimeTissue SampleTranslatingValidationbasecommunity engagementcomputerized data processingcostdata acquisitiondata qualitydesignexperimental studyflexibilitygraphical user interfaceimprovedinnovationionization constantmeetingsnew technologyprogramsprotein foldingquantum chemistryrecruitsenior facultysmall moleculesolid statesolid state nuclear magnetic resonancetechnology developmenttoolweb site
项目摘要
INTRODUCTION TO REVISED APPLICATION
The A0 grant was submitted in May 2019, before Prof. Alexander Barnes moved to ETH-Zurich and before Prof.
Chad Rienstra was recruited to UW-Madison. Now Rienstra is officially a Full Professor at UW-Madison, after
having negotiated major investments in the solid-state NMR (SSNMR) program at NMRFAM (new and/or moving
from Illinois) including three shielded 600 MHz magnets, one 750 MHz wide bore magnet, four spectrometers,
several custom-designed magic-angle spinning (MAS) probes at 600-750 MHz, and upgrades to the 900 MHz
spectrometer, which immediately have had an impact on data collection for DBP6 in late 2019 and for other
experiments in progress during early 2020.
Furthermore, the National Science Foundation Mid-Scale Research Infrastructure-2 proposal on "Network for
Advanced NMR", which was submitted by UW-Madison PIs (Rienstra and Henzler-Wildman) in collaboration
with Jeff Hoch at UConn Health and Art Edison at U. Georgia, is in late stages of negotiation and review with
NSF. If funded, this grant would bring a 1.1 GHz dedicated SSNMR spectrometer to NMRFAM in ~2022-23.
These developments have motivated several changes to this A1 application which more explicitly emphasizes
the SSNMR program at NMRFAM:
(1) Rienstra is now contact PI and Henzler-Wildman co-PI.
(2) TR&D1 now includes sub-aims targeting development of micro-rotor packing and sample manipulation
tools to leverage recent breakthroughs in ultra-fast MAS (>100 kHz) at <1 mm rotor diameters; this
broadens the scope and impact of TR&D 1. Baselines and benchmarks for NMR under gradients are also
more clearly described and proof-of-principle experiments are in place.
(3) TR&D2 now addresses critical bottlenecks in SSNMR data collection, emphasizing:
(a) automation for parameter optimization and spectrometer configuration;
(b) new narrow bore magic-angle spinning probe designs at 600-900 MHz (that will be applicable at 1.1
GHz and higher in the future); and
(c) real-time feedback interaction with data processing (TR&D3).
(4) TR&D3 now leverages NMRFAM software products and continuing technology development for solid-
state NMR, including assignment, structure determination, refinement and validation tools, and it is more
clearly integrated with the rest of the proposal.
(5) DBPs 5, 6 and 7 have been changed to include well-developed and impactful collaborations between
Rienstra and Paul Kotzbauer (Wash. U. Medicine, Lewy bodies and synucleiopathies), Marty Burke (U.
Illinois, antifungal drugs), and James Morrissey (U. Michigan, blood coagulation).
Overall the proposal is now organized in (we think) a more logical/chronological manner, with TR&D1
emphasizing samples, TR&D2 the spectrometer and probes, and TR&D3 the software and analysis procedures.
The proposal body further explains how these developments greatly augment the cost-benefit ratio for the project
and integrate with the current user program and the long-term vision of NMRFAM.
The revisions also address the overarching concerns of reviewers of the A0 application including "narrow
scope/modest innovation in TR&D1"; "weak integration of TR&D3"; cost-benefit ratio; preliminary data; solution
vs. solids emphasis of TR&D3; innovation; context (addressing competing ideas and precedents); and specificity
of outcomes. Finally, we have clarified the premise and approach with respect to asymmetry in membrane
proteins.
修订后的申请简介
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Katherine Anne Henzler-Wildman其他文献
Katherine Anne Henzler-Wildman的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Katherine Anne Henzler-Wildman', 18)}}的其他基金
Expanding the Scope of NMR Sample Preparation
扩大 NMR 样品制备的范围
- 批准号:
10089600 - 财政年份:2021
- 资助金额:
$ 113.97万 - 项目类别:
Expanding the Scope of NMR Sample Preparation
扩大 NMR 样品制备的范围
- 批准号:
10573324 - 财政年份:2021
- 资助金额:
$ 113.97万 - 项目类别:
NMR Technologies for Integrating Structure, Function and Disease
整合结构、功能和疾病的 NMR 技术
- 批准号:
10089598 - 财政年份:2021
- 资助金额:
$ 113.97万 - 项目类别:
Molecular Mechanisms of Channels and Transporters
通道和转运蛋白的分子机制
- 批准号:
10608951 - 财政年份:2021
- 资助金额:
$ 113.97万 - 项目类别:
NMR Technologies for Integrating Structure, Function and Disease
整合结构、功能和疾病的 NMR 技术
- 批准号:
10323282 - 财政年份:2021
- 资助金额:
$ 113.97万 - 项目类别:
Molecular Mechanisms of Channels and Transporters
通道和转运蛋白的分子机制
- 批准号:
10204502 - 财政年份:2021
- 资助金额:
$ 113.97万 - 项目类别:
Expanding the Scope of NMR Sample Preparation
扩大 NMR 样品制备的范围
- 批准号:
10323284 - 财政年份:2021
- 资助金额:
$ 113.97万 - 项目类别:
Molecular Mechanisms of Channels and Transporters
通道和转运蛋白的分子机制
- 批准号:
10394922 - 财政年份:2021
- 资助金额:
$ 113.97万 - 项目类别:
CONFORMATIONAL DYNAMICS IN ION CHANNEL SELECTIVITY AND GATING
离子通道选择性和门控中的构象动力学
- 批准号:
8945932 - 财政年份:2015
- 资助金额:
$ 113.97万 - 项目类别:
CONFORMATIONAL DYNAMICS IN ION CHANNEL SELECTIVITY AND GATING
离子通道选择性和门控中的构象动力学
- 批准号:
9133430 - 财政年份:2015
- 资助金额:
$ 113.97万 - 项目类别:
相似海外基金
EXCESS: The role of excess topography and peak ground acceleration on earthquake-preconditioning of landslides
过量:过量地形和峰值地面加速度对滑坡地震预处理的作用
- 批准号:
NE/Y000080/1 - 财政年份:2024
- 资助金额:
$ 113.97万 - 项目类别:
Research Grant
Collaborative Research: FuSe: R3AP: Retunable, Reconfigurable, Racetrack-Memory Acceleration Platform
合作研究:FuSe:R3AP:可重调、可重新配置、赛道内存加速平台
- 批准号:
2328975 - 财政年份:2024
- 资助金额:
$ 113.97万 - 项目类别:
Continuing Grant
SHINE: Origin and Evolution of Compressible Fluctuations in the Solar Wind and Their Role in Solar Wind Heating and Acceleration
SHINE:太阳风可压缩脉动的起源和演化及其在太阳风加热和加速中的作用
- 批准号:
2400967 - 财政年份:2024
- 资助金额:
$ 113.97万 - 项目类别:
Standard Grant
Collaborative Research: FuSe: R3AP: Retunable, Reconfigurable, Racetrack-Memory Acceleration Platform
合作研究:FuSe:R3AP:可重调、可重新配置、赛道内存加速平台
- 批准号:
2328973 - 财政年份:2024
- 资助金额:
$ 113.97万 - 项目类别:
Continuing Grant
Market Entry Acceleration of the Murb Wind Turbine into Remote Telecoms Power
默布风力涡轮机加速进入远程电信电力市场
- 批准号:
10112700 - 财政年份:2024
- 资助金额:
$ 113.97万 - 项目类别:
Collaborative R&D
Collaborative Research: FuSe: R3AP: Retunable, Reconfigurable, Racetrack-Memory Acceleration Platform
合作研究:FuSe:R3AP:可重调、可重新配置、赛道内存加速平台
- 批准号:
2328972 - 财政年份:2024
- 资助金额:
$ 113.97万 - 项目类别:
Continuing Grant
Collaborative Research: A new understanding of droplet breakup: hydrodynamic instability under complex acceleration
合作研究:对液滴破碎的新认识:复杂加速下的流体动力学不稳定性
- 批准号:
2332916 - 财政年份:2024
- 资助金额:
$ 113.97万 - 项目类别:
Standard Grant
Collaborative Research: A new understanding of droplet breakup: hydrodynamic instability under complex acceleration
合作研究:对液滴破碎的新认识:复杂加速下的流体动力学不稳定性
- 批准号:
2332917 - 财政年份:2024
- 资助金额:
$ 113.97万 - 项目类别:
Standard Grant
Collaborative Research: FuSe: R3AP: Retunable, Reconfigurable, Racetrack-Memory Acceleration Platform
合作研究:FuSe:R3AP:可重调、可重新配置、赛道内存加速平台
- 批准号:
2328974 - 财政年份:2024
- 资助金额:
$ 113.97万 - 项目类别:
Continuing Grant
Study of the Particle Acceleration and Transport in PWN through X-ray Spectro-polarimetry and GeV Gamma-ray Observtions
通过 X 射线光谱偏振法和 GeV 伽马射线观测研究 PWN 中的粒子加速和输运
- 批准号:
23H01186 - 财政年份:2023
- 资助金额:
$ 113.97万 - 项目类别:
Grant-in-Aid for Scientific Research (B)