A prospective registry, biobank and observational study of food allergy
食物过敏的前瞻性登记、生物库和观察研究
基本信息
- 批准号:10581632
- 负责人:
- 金额:$ 517.92万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-03-01 至 2024-02-29
- 项目状态:已结题
- 来源:
- 关键词:AdolescentAffectAgeAllergicAllergic ReactionAllergy to eggsAllergy to peanutsAmericanAsthmaBasophilsCaringCharacteristicsClinicalClinical TreatmentClinical TrialsComplicationDataDiseaseEducationEmergency department visitEnrollmentFoodFood HypersensitivityFrequenciesFrightFundingFunding OpportunitiesFutureGeneticGoalsHealth TechnologyHeterogeneityHypersensitivityIgEImmunologicsIndividualInfrastructureInterventionInvestigationKnowledgeLeadLeadershipLifeMediatingMedicalMethodsMilkMilk HypersensitivityMobile Health ApplicationMonitorObservational StudyPatient RecruitmentsPatientsPhenotypePopulationPreventionReactionRegistriesResearchResourcesRiskRisk MarkerRisk ReductionSamplingSeveritiesShapesbiobankbiomarker identificationclinical careclinical investigationclinically relevantcohortcomorbiditydesigneggexperiencefood allergeninnovationmHealthmethod developmentnovelparticipant enrollmentpersonalized medicinephenotypic biomarkerpredictive markerprospectivereaction raterecruitrepositoryrisk predictionrisk/benefit ratiospecific biomarkerstreatment response
项目摘要
Project Summary
Food allergy is a common disease that affects up to 15 million Americans. Although clinically there appears to
be a wide spectrum of disease, sub-types of food allergy with different clinical courses, co-morbidities and
responses to therapy have not been systematically identified. Identifying such sub-types of food allergy will
allow for tailored care of food allergic individuals. A second major research gap is our understanding of the
absolute risk and predictors of serious allergic reactions among those with food allergy who are receiving high
quality medical care. Establishing the risk and predictors of serious reactions will have critical implications for
determining the risk:benefit ratio for food allergy treatments, educating patients, identifying targets for reducing
risk, and determining the best candidates for treatment. This proposal is create a large repository, biobank and
prospective observational study of food allergic patients by enrolling 2000 subjects with IgE mediated milk, egg
or peanut allergy. Sub-types of food allergy will be identified using unsupervised methods based on
comprehensive clinical and immunologic data. The rate of reactions to foods will be closely monitored using
innovative mobile health technology. In addition to those major goals, the infrastructure created in this
observational cohort through the formation of a registry of well phenotyped food allergic patients and the
development of methods to monitor reactions will enable subsequent clinical trials funded by CoFAR to recruit
and proceed efficiently, and will provide samples for the opportunity fund. The specific aims of this project are:
(1) To establish a large registry and biobank of subjects with milk, egg and/or peanut allergy, (2) To establish
phenotypes of food allergy by clinically and immunologically characterizing food allergic individuals (Aim 2A)
and to identify predictors of these phenotypes (Aim 2B), and (3) To establish the rate of food allergic reactions
among individuals with food allergy (Aim 3A) and determine predictors of reaction frequency and severity (Aim
3B). The results of these investigations will help inform clinical care of food allergic individuals by allowing for
tailored care of food allergic individuals, and by informing the risk:benefit ratio for food allergy treatments. This
project will also critically advance research into food allergy by providing a registry from which to recruit
patients for CoFAR, data on phenotypes which can be used to shape future clinical investigations, and data on
predictors of reaction rates which can be used to design novel interventions.
项目摘要
食物过敏是一种常见疾病,影响多达1500万美国人。尽管临床上似乎
是一种广泛的疾病,具有不同临床病程的食物过敏亚型,合并症和
对治疗的反应尚未系统地确定。识别这些食物过敏的亚型将
允许对食物过敏的个体进行定制护理。第二个主要的研究差距是我们对
食物过敏者中严重过敏反应的绝对风险和预测因素,
优质医疗服务。确定严重反应的风险和预测因素将对以下方面产生重要影响:
确定食物过敏治疗的风险:效益比,教育患者,确定减少食物过敏的目标,
风险,并确定治疗的最佳候选人。这个建议是建立一个大型的储存库,生物库,
2000例食物过敏患者IgE介导的牛奶、鸡蛋过敏的前瞻性观察研究
或者花生过敏食物过敏的亚型将使用基于以下内容的无监督方法进行识别:
全面的临床和免疫学数据。对食物的反应率将被密切监测,
创新的移动的医疗技术。除了这些主要目标之外,
通过形成良好表型食物过敏患者的登记表和观察队列,
开发监测反应的方法将使CoFAR资助的后续临床试验能够招募
并将为机会基金提供样本。该项目的具体目标是:
(1)建立牛奶、鸡蛋和/或花生过敏受试者的大型登记和生物库,(2)建立
通过临床和免疫学表征食物过敏个体来确定食物过敏表型(Aim 2A)
并确定这些表型的预测因子(目的2B);(3)确定食物过敏反应的发生率
在食物过敏个体中(Aim 3A),并确定反应频率和严重程度的预测因子(Aim
3B)。这些调查的结果将有助于通过允许食物过敏个体的临床护理,
食物过敏患者的量身定制护理,并告知食物过敏治疗的风险:收益比。这
该项目还将通过提供一个登记处来招募新的研究人员,
用于CoFAR的患者,可用于塑造未来临床研究的表型数据,以及
反应率的预测因子,可用于设计新的干预措施。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Corinne Keet其他文献
Corinne Keet的其他文献
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{{ truncateString('Corinne Keet', 18)}}的其他基金
The effect of a housing mobility program on environmental exposures and asthma morbidity among low-income minority children
住房流动计划对低收入少数族裔儿童的环境暴露和哮喘发病率的影响
- 批准号:
10202894 - 财政年份:2020
- 资助金额:
$ 517.92万 - 项目类别:
A prospective registry, biobank and observational study of food allergy
食物过敏的前瞻性登记、生物库和观察研究
- 批准号:
10363634 - 财政年份:2017
- 资助金额:
$ 517.92万 - 项目类别:
The effect of a housing mobility program on environmental exposures and asthma morbidity among low-income minority children
住房流动计划对低收入少数族裔儿童的环境暴露和哮喘发病率的影响
- 批准号:
10469499 - 财政年份:2016
- 资助金额:
$ 517.92万 - 项目类别:
Early Peanut Introduction: Translation to Clinical Practice
早期花生介绍:转化为临床实践
- 批准号:
9153173 - 财政年份:2016
- 资助金额:
$ 517.92万 - 项目类别:
The effect of a housing mobility program on environmental exposures and asthma morbidity among low-income minority children
住房流动计划对低收入少数族裔儿童的环境暴露和哮喘发病率的影响
- 批准号:
10296756 - 财政年份:2016
- 资助金额:
$ 517.92万 - 项目类别:
The effect of a housing mobility program on environmental exposures and asthma morbidity among low-income minority children
住房流动计划对低收入少数族裔儿童的环境暴露和哮喘发病率的影响
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9888210 - 财政年份:2016
- 资助金额:
$ 517.92万 - 项目类别:
Early Peanut Introduction: Translation to Clinical Practice
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- 批准号:
9491694 - 财政年份:2016
- 资助金额:
$ 517.92万 - 项目类别:
Temporal Trends in Food Sensitization in U.S. Children
美国儿童食物过敏的时间趋势
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8564924 - 财政年份:2013
- 资助金额:
$ 517.92万 - 项目类别:
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8676849 - 财政年份:2013
- 资助金额:
$ 517.92万 - 项目类别:
Development of a Dissolving Film for Allergen Immunotherapy in Children
开发用于儿童过敏原免疫治疗的溶解膜
- 批准号:
8510886 - 财政年份:2013
- 资助金额:
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