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Early Peanut Introduction: Translation to Clinical Practice

早期花生介绍：转化为临床实践

基本信息

批准号：
9153173
负责人：
Corinne Keet
金额：
$ 86万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-06-27 至 2021-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9153173
关键词：
African American Allergens Allergic Allergy to eggs Allergy to peanuts Blood Categories Characteristics Child Clinical Clinical Practice Guideline Clinical Trials Consensus Consumption Data Development Diagnosis Diagnostic Diet Dose Eczema Enrollment Ensure Ethnic Origin Family history of Food Hypersensitivity Frequencies Goals Gold Guidelines Hypersensitivity IgE Individual Infant Ingestion Investigation Life Measurement Measures Modality Observational Study Office Visits Oral Pattern Performance Population Prevention Primary Health Care Race Randomized Reaction Resources Risk Sensitivity and Specificity Siblings Testing Translations Underrepresented Groups Visit Work base clinical practice cohort ethnic difference ethnic minority population food challenge high risk high risk infant infancy meetings prevent prospective racial and ethnic racial and ethnic disparities randomized trial screening skin prick test

项目摘要

Project Summary: The recent finding that early introduction of peanut can prevent ~70-90% of peanut allergy is a major step towards prevention of food allergy. However, because that finding was from a clinical trial in a very select population, there are several major questions that must be answered in order to implement these findings into clinical practice without causing more harm than good. These questions include who, if anyone, should be screened prior to early introduction for peanut allergy, how this screening should be done, and what quantity of peanut ingestion is needed to prevent peanut allergy. Our goal is to answer these critical questions so that the potential of these recent findings can be realized. To that end, we will enroll 400 infants at high- risk of peanut allergy. These infants will be given a peanut skin prick test, peanut food challenge and have blood drawn for measurement of peanut IgE, and then will be followed for assessment of peanut consumption and development of peanut allergy. Aim 1 is to determine the rate of peanut reactivity in infancy among these high risk groups, Aim 2 is to characterize the performance of possible screening tests for peanut allergy in infancy, and Aim 3 is to characterize the peanut consumption patterns of these infants after screening and to determine the association with development of peanut allergy. Exploratory Aim 4 is to understand racial/ethnic disparities in risk of reactivity and diagnostic parameters of screening tests.

项目概要：最近发现，早期引进花生可以预防70-90%的花生过敏，这是一个重要的研究领域。向预防食物过敏迈出了重要一步。然而，由于该发现来自临床研究，在非常精选的人群中进行试验，有几个主要问题必须得到回答，以便将这些发现应用到临床实践中，而不会造成弊大于利。这些问题包括谁，如果有的话，应该在早期引入之前进行筛查。花生过敏，这种筛查应该如何进行，以及花生摄入量是多少防止花生过敏我们的目标是回答这些关键问题，这些最新发现的潜力可以实现。为此，我们将招募400名高- 花生过敏的风险。这些婴儿将接受花生皮肤点刺试验、花生食物挑战并抽血检测花生IgE，然后进行随访评估花生消费和花生过敏的发展。目标1是确定在这些高危人群中，婴儿期的花生反应性，目的2是表征在婴儿期进行可能的花生过敏筛查试验，目标3是在筛查后描述这些婴儿的花生消费模式，并确定与花生过敏症的关系。探索目标4是了解反应性风险和筛查试验诊断参数的种族/民族差异。