Temporal Trends in Food Sensitization in U.S. Children

美国儿童食物过敏的时间趋势

• 批准号: 8564924
• 负责人: Corinne Keet
• 金额: $ 30.46万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-05 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8564924
• 关键词: 20 year old; Allergens; Biological Markers; Centers for Disease Control and Prevention (U.S.); Child; Clinical; Data; Diagnosis; Disease; Epidemic; Epidemiology; Ethnic Origin; Ethnic group; Food; Food Hypersensitivity; Hispanics; Hypersensitivity; IgE; Investments; Laboratories; Manuscripts; Measures; Milk; National Health and Nutrition Examination Survey; Not Hispanic or Latino; Outcome Measure; Patient Self-Report; Peanuts - dietary; Population; Prevalence; Questionnaires; Reporting; Research; Sampling; Serum; Shrimp; Surveys; Testing; Time; United States National Institutes of Health; aged; base; caucasian American; egg; environmental change; experience; food allergen; high risk; primary outcome; public health relevance; racial and ethnic disparities; systematic review; trend

DESCRIPTION (provided by applicant): Food allergy appears to have risen rapidly in prevalence over the past few decades, leading to much research into the causes of this apparent 'epidemic'. Yet, because the data showing increased prevalence are largely based on questionnaires, and we know that questionnaires overestimate clinically confirmed food allergy, we truly do not know how real the apparent epidemic is. It is possible that the increased prevalence seen in the questionnaires represents changes in the diagnosis of food allergy, and that biologic markers of this disease remain unchanged. An additional unknown is whether the growing ethnic/racial disparities in food allergy prevalence seen in the self-reported data relate to true biologic differences. In order to determine whether the trends that are found in self reported food allergy correlate with changes in biologic measures of food allergy, we propose to measure food specific IgE in stored samples from the National Health and Nutrition Examination Survey (NHANES) III, collected from 1988-1994, in order to compare it to that already measured in NHANES 2005-6. Aim 1 is to compare the prevalence of sensitization and higher likelihood of clinical food allergy, both as measured by specific IgE to milk, egg, peanut or shrimp, in U.S. children over this approximately 15 year period. Aim 2 is to test the hypothesis that Non-Hispanic Blacks have experienced greater increases in prevalence of sensitization and higher specific IgE over this period. Combined, these aims will answer fundamental questions in the field of food allergy epidemiology.

描述（由申请人提供）：在过去的几十年里，食物过敏的流行率似乎迅速上升，导致了对这种明显的“过敏”原因的大量研究。然而，由于显示患病率增加的数据主要是基于问卷调查，我们知道问卷调查高估了临床证实的食物过敏，我们真的不知道这种明显的流行病有多真实的。调查问卷中发现的患病率增加可能代表食物过敏诊断的变化，而这种疾病的生物标志物保持不变。另一个未知数是，在自我报告的数据中看到的食物过敏患病率的种族/种族差异是否与真正的生物学差异有关。为了确定自我报告的食物过敏的趋势是否与食物过敏的生物学指标的变化相关，我们建议从1988-1994年收集的国家健康和营养检查调查（NHANES）III中测量储存样本中的食物特异性IgE，以将其与NHANES 2005-6中已经测量的进行比较。目的1是比较在这大约15年期间，美国儿童中致敏的患病率和临床食物过敏的较高可能性，这两种情况都是通过对牛奶、鸡蛋、花生或虾的特异性IgE测量的。目的2是检验以下假设：在此期间，非西班牙裔黑人的致敏患病率增加幅度更大，特异性IgE更高。结合起来，这些目标将回答食物过敏流行病学领域的基本问题。