BLRD Research Career Scientist Award Application

BLRD 研究职业科学家奖申请

基本信息

  • 批准号:
    10587736
  • 负责人:
  • 金额:
    --
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-10-01 至 2027-09-30
  • 项目状态:
    未结题

项目摘要

Traumatic brain injury and other neurodegenerative disorders, e.g., Alzheimer’s Disease (AD), amyotrophic lateral sclerosis (Lou Gehrig’s disease, ALS), and related conditions, have an especially significant and increasing prevalence in the Veteran population. Gulf War illness has a high incidence among Veterans that served in the 1990-1991 Persian Gulf conflict and neurologic problems are common. It is essential that the underlying mechanisms that contribute to these conditions are understood so that treatments can be developed to improve the outcomes for Veterans and others. I have been studying the molecular genetic aspects of neurons and glia in the brain and spinal cord to determine how we can best modulate regulatory pathways to block and reverse neurodegenerative signaling that results in behavioral problems. In the course of these investigations, we examine human CNS samples obtained from brain banks, animal models, and model neurons in tissue culture. We evaluate gene expression changes and interactions that occur during the course of neurodegeneration in a variety of brain and spinal cord samples and model systems to compare alterations that are specific to the various disorders so that we can characterize factors that can be targeted to obtain neuroprotection and improved functional performance. I have determined key mechanisms responsible for central nervous system neurodegeneration. Areas of current discovery include Alzheimer's disease, important to the aging Veteran and general population, and traumatic brain injury which is becoming increasingly understood in terms of injury exposures in sports and importantly, is unfortunately the signature affliction of recently deployed military forces. In this arena I have, for example, identified therapeutic targets by defining neurodegenerative mechanisms and demonstrating that attacking these targets results in reduced activation of caspase- 3, improved neuroprotective gene expression in the brain, and reduced functional deficits, measured with behavioral and cognitive tests, by treatment after injury. We have found that several genes responsible for the loss of neuronal function are influenced significantly by a handful of inflammatory responsive regulatory factors that control the transcription rates, or gene expression, of the proteins important to neuronal health. For example, we found that inflammatory responsive regulatory transcription factors can be modulated to produce neuroprotective levels of intracellular proteins through selective upregulation and downregulation. By treating models with our intracellular, regulatory modulators, we have not only positively influenced biochemical pathways, we have demonstrated improved memory function in neurodegenerative conditions compared to untreated controls. We are currently extending this research to additional neurological problems that occur more frequently in Veterans and are seeking to advance beneficial therapeutic strategies.
创伤性脑损伤和其他神经退行性疾病,如阿尔茨海默病(AD),

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Bruce A. Citron其他文献

Huntington Potter. Caffeine reverses cognitive impairment and decreases brain amyloid-βlevels in aged Alzheimer's disease mice.
亨廷顿·波特 (Huntington Potter) 指出,咖啡因可逆转老年阿尔茨海默病小鼠的认知障碍并降低大脑淀粉样蛋白水平。
  • DOI:
  • 发表时间:
    2009
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Gary W. Arendash;Takashi Mori;Chuanhai Cao;Malgorzata B. Mamcarz;Melissa J. Runfeldt;Alexander Dickson;Kavon Rezai-Zadeh;Jun Tan;Bruce A. Citron;Xiaoyang Lin;Valentina Echeverria
  • 通讯作者:
    Valentina Echeverria
Mutation in the 4a-carbinolamine dehydratase gene leads to mild hyperphenylalaninemia with defective cofactor metabolism.
4α-甲醇胺脱水酶基因突变会导致轻度高苯丙氨酸血症并伴有辅因子代谢缺陷。
  • DOI:
  • 发表时间:
    1993
  • 期刊:
  • 影响因子:
    9.8
  • 作者:
    Bruce A. Citron;Seymour Kaufman;Sheldon Milstien;Edwin W. Naylor;L. Carol;Greene;Michael D. Davis
  • 通讯作者:
    Michael D. Davis
Biological links between traumatic brain injury and Parkinson’s disease
  • DOI:
    10.1186/s40478-020-00924-7
  • 发表时间:
    2020-04-07
  • 期刊:
  • 影响因子:
    5.700
  • 作者:
    Vedad Delic;Kevin D. Beck;Kevin C. H. Pang;Bruce A. Citron
  • 通讯作者:
    Bruce A. Citron
Sex and Genotype Affect Mouse Hippocampal Gene Expression in Response to Blast-Induced Traumatic Brain Injury
  • DOI:
    10.1007/s12035-025-04879-5
  • 发表时间:
    2025-04-03
  • 期刊:
  • 影响因子:
    4.300
  • 作者:
    Kathleen E. Murray;Arun Reddy Ravula;Victoria A. Stiritz;Tara P. Cominski;Vedad Delic;Caralina Marín de Evsikova;Kakulavarapu V. Rama Rao;Namas Chandra;Kevin D. Beck;Bryan J. Pfister;Bruce A. Citron
  • 通讯作者:
    Bruce A. Citron

Bruce A. Citron的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Bruce A. Citron', 18)}}的其他基金

SDR: Genomic analysis of blast tube induced TBI in mice
SDR:小鼠爆管诱发 TBI 的基因组分析
  • 批准号:
    10092813
  • 财政年份:
    2020
  • 资助金额:
    --
  • 项目类别:
SDR: Genomic analysis of blast tube induced TBI in mice
SDR:小鼠爆管诱发 TBI 的基因组分析
  • 批准号:
    10657467
  • 财政年份:
    2020
  • 资助金额:
    --
  • 项目类别:
SDR: Genomic analysis of blast tube induced TBI in mice
SDR:小鼠爆管诱发 TBI 的基因组分析
  • 批准号:
    9916092
  • 财政年份:
    2020
  • 资助金额:
    --
  • 项目类别:
SDR: Genomic analysis of blast tube induced TBI in mice
SDR:小鼠爆管诱发 TBI 的基因组分析
  • 批准号:
    10438523
  • 财政年份:
    2020
  • 资助金额:
    --
  • 项目类别:
ShEEP Request for Confocal Microscope System
ShEEP 请求共焦显微镜系统
  • 批准号:
    9794913
  • 财政年份:
    2019
  • 资助金额:
    --
  • 项目类别:
Preventing TBI-Induced Chronic Functional Loss with a Neuroprotective Antioxidant
使用神经保护性抗氧化剂预防 TBI 引起的慢性功能丧失
  • 批准号:
    9392490
  • 财政年份:
    2014
  • 资助金额:
    --
  • 项目类别:
Preventing TBI-Induced Chronic Functional Loss with a Neuroprotective Antioxidant
使用神经保护性抗氧化剂预防 TBI 引起的慢性功能丧失
  • 批准号:
    9924245
  • 财政年份:
    2014
  • 资助金额:
    --
  • 项目类别:
Preventing TBI-Induced Chronic Functional Loss with a Neuroprotective Antioxidant
使用神经保护性抗氧化剂预防 TBI 引起的慢性功能丧失
  • 批准号:
    9567849
  • 财政年份:
    2014
  • 资助金额:
    --
  • 项目类别:
Preventing TBI-Induced Chronic Functional Loss with a Neuroprotective Antioxidant
使用神经保护性抗氧化剂预防 TBI 引起的慢性功能丧失
  • 批准号:
    9038791
  • 财政年份:
    2014
  • 资助金额:
    --
  • 项目类别:
Preventing TBI-Induced Chronic Functional Loss with a Neuroprotective Antioxidant
使用神经保护性抗氧化剂预防 TBI 引起的慢性功能丧失
  • 批准号:
    10174732
  • 财政年份:
    2014
  • 资助金额:
    --
  • 项目类别:

相似海外基金

Factors and effect of visual inattention on fall accidents
视觉注意力不集中对坠落事故的影响因素及影响
  • 批准号:
    23K19000
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
    Grant-in-Aid for Research Activity Start-up
SBIR Phase I: Comprehensive, Human-Centered, Safety System Using Physiological and Behavioral Sensing to Predict and Prevent Workplace Accidents
SBIR 第一阶段:利用生理和行为感知来预测和预防工作场所事故的综合性、以人为本的安全系统
  • 批准号:
    2321538
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
    Standard Grant
Preventing Accidents in School lunch for Food Allergies: Consideration of Strategies and Development of Support Applications.
预防学校午餐中的食物过敏事故:考虑策略和开发支持应用程序。
  • 批准号:
    23K01977
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Political Geographies of Human Accidents and Trauma Care in Mumbai's Commuter Railways
孟买通勤铁路中人类事故和创伤护理的政治地理
  • 批准号:
    ES/X006239/1
  • 财政年份:
    2022
  • 资助金额:
    --
  • 项目类别:
    Fellowship
Multiscale, Multi-fidelity and Multiphysics Bayesian Neural Network (BNN) Machine Learning (ML) Surrogate Models for Modelling Design Based Accidents
用于基于事故建模设计的多尺度、多保真度和多物理场贝叶斯神经网络 (BNN) 机器学习 (ML) 替代模型
  • 批准号:
    2764855
  • 财政年份:
    2022
  • 资助金额:
    --
  • 项目类别:
    Studentship
OTIMO - Applying telematics to the learner driver market through innovations in AI and behavioural intervention, to improve driving and reduce accidents.
OTIMO - 通过人工智能和行为干预创新,将远程信息处理应用于学习驾驶员市场,以改善驾驶并减少事故。
  • 批准号:
    10035763
  • 财政年份:
    2022
  • 资助金额:
    --
  • 项目类别:
    Collaborative R&D
Comprehensive safety strategy to achieve reducing accidents of central venous access port catheter rapture
综合安全策略,实现减少中心静脉通路导管断裂事故
  • 批准号:
    22K17330
  • 财政年份:
    2022
  • 资助金额:
    --
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
Computational Scientific Study on Mechanism of Multiphase Thermal-Hydraulic Phenomena Related to IVR in Core Disruptive Accidents
堆芯破坏性事故中与IVR相关的多相热工水力现象机理的计算科学研究
  • 批准号:
    21K04944
  • 财政年份:
    2021
  • 资助金额:
    --
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Practical application of exposure dose evaluation method by DNA damage analysis for radiation exposure accidents
DNA损伤分析照射剂量评估方法在辐射事故中的实际应用
  • 批准号:
    21H01861
  • 财政年份:
    2021
  • 资助金额:
    --
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
An Australian Pilot Study of an Injury Prediction Algorithm for Early Rescue in Word Car Accidents
澳大利亚针对世界车祸早期救援的伤害预测算法的试点研究
  • 批准号:
    21H01578
  • 财政年份:
    2021
  • 资助金额:
    --
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了