Support For Infrastructure of Childhood Leukemia Environmental Research

支持儿童白血病环境研究基础设施

• 批准号: 10588560
• 负责人: Catherine Metayer
• 金额: $ 38.61万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-30 至 2028-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10588560
• 关键词: Acceleration; Acute Lymphocytic Leukemia; Acute Myelocytic Leukemia; Address; Affect; Asian; Awareness; Birth Weight; Breast Feeding; California; Case/Control Studies; Chemical Exposure; Chemicals; Child; Childhood; Childhood Leukemia; Collaborations; Communities; Costa Rica; Costa Rican; Country; Data; Data Sources; Databases; Developed Countries; Development; Diet; Disease; Disparity; Education; Education and Outreach; Educational workshop; Enrollment; Environment; Environmental Epidemiology; Environmental Health; Environmental Risk Factor; Equipment and supply inventories; Ethnic Population; Etiology; Exposure to; FAIR principles; Funding; Genetic; Goals; Guatemala; Health; Health Professional; Hispanic; Immune; Immune response; Incidence; Individual; Infrastructure; Institution; International; Investigation; Latin America; Latin American; Latinx; Latinx population; Link; Maintenance; Malignant Childhood Neoplasm; Malignant Neoplasms; Mexican; Mexico; Multimedia; Myelogenous; National Institute of Environmental Health Sciences; Neighborhoods; Outcome; Outcome Study; Population; Population Heterogeneity; Population Study; Prevention; Procedures; Prognosis; Public Health; Publications; R24; Recording of previous events; Research; Research Personnel; Resource Sharing; Resources; Risk; Risk Factors; Role; Seminal; Socioeconomic Status; Source; Survivors; System; Translational Research; Tumor Biology; United States; Vitamins; Vulnerable Populations; bilingualism; built environment; carcinogenicity; case control; community engagement; data archive; data sharing; data sharing networks; design; dietary; disorder risk; electronic book; epidemiology study; ethnic diversity; genetic risk factor; health organization; improved; interoperability; leukemia; medical specialties; outreach; prenatal; process improvement; public database; racial population; social; social factors; stressor; survivorship; trend; webinar

ABSTRACT Leukemia is the most common pediatric cancer affecting more than 40,000 children worldwide each year. During the last decades, childhood leukemia incidence has increased in the US by ~35% overall, with an even larger rise among LatinX. Similar trends are also observed in several Latin American countries. This rapid increase points to the critical role of environmental factors in the development childhood leukemia, possibly in combination with genetic factors. Despite improved prognosis of childhood leukemia overall, there are major differences by subtype, region, racial/ethnic group, and socio-economic status, and leukemia survivors remain at risk for serious lifelong complications. Altogether, these observations highlight the need to support more research and prevention to reduce leukemia burden and disparity. The overall objective of this U24 competing renewal is to expand the support of existing population studies (here case-control design) to accelerate childhood leukemia environmental research and prevention, with a focus on LatinX populations. In the first R24 cycle (2017-22), we maintained and enhanced the resources and data sharing of two NIEHS-funded studies with large numbers of LatinX children in California, United States and Guatemala. To further address childhood leukemia disparity in LatinX, while increasing diversity of the research team, we now propose to (i) include additional childhood leukemia studies with low-resources in Mexico and Costa Rica, (ii) coordinate research translation/prevention among participating countries, and (iii) collaborate with LatinX researchers and health workers in California and Latin America. The four participating studies have enrolled 8,480 childhood leukemia cases and 4,462 controls, and have collected a wealth of environmental/genetic data and biospecimens providing the most comprehensive resources in LatinX populations worldwide. Individually or as part of the Childhood Cancer and Leukemia Consortium (CLIC), these studies have produced seminal findings, documenting the prenatal origin of childhood leukemia and identifying many factors that contribute to the increased or decreased risks of the disease including chemical exposures, diet/vitamins, breastfeeding, immune response, birthweight and genetic factors. The maintenance of these resources and the enhancement of data sharing procedures are needed to efficiently expand ongoing etiologic and tumor-biology studies of childhood leukemia, especially myeloid subtypes which are more common in LatinX, and uncover sources of disparity in leukemia risk and outcomes. To achieve our goals, we plan to (1) use an interoperable management system REDCap to provide unifying support for management, harmonization, storage and sharing of study resources; (2) enrich case-control studies by conducting linkages to population-level databases on exposures to potential carcinogenic agents/mixtures and social/built environments; (3) facilitate broader data use nationally and internationally with the CLIC Consortium, and (4) expand community engagement with the public, lay health workers, and health professionals in the US and Latin American countries to increase awareness about preventable risk factors of childhood leukemia.

抽象的 白血病是最常见的儿科癌症，每年影响全球40,000多名儿童。期间 在过去的几十年中，美国的童年白血病的发病率增加了约35％，甚至更大 在拉丁裔之间上升。在几个拉丁美洲国家也观察到类似的趋势。这种快速增加 指出环境因素在开发儿童白血病中的关键作用，可能是结合 与遗传因素。尽管总体上对儿童白血病的预后有所改善，但仍有主要差异 亚型，地区，种族/族裔和社会经济地位和白血病幸存者仍处于严重严重的危险中 终身并发症。这些观察总共凸显了支持更多研究和 预防减轻白血病负担和差异。该U24竞争续约的总体目标是 扩大现有人群研究的支持（此处病例对照设计），以加速儿童白血病 环境研究和预防，重点是拉丁人。在第一个R24周期（2017-22）中，我们 维护并增强了两项NIEHS资助研究的资源和数据共享 加利福尼亚，美国和危地马拉的拉丁裔儿童。进一步解决儿童白血病差异 Latinx在增加研究团队的多样性的同时，我们现在建议（i）包括额外的童年 白血病研究在墨西哥和哥斯达黎加，（ii）协调研究翻译/预防 在参与国家中，（iii）与加利福尼亚州的拉丁裔研究人员和卫生工作者合作 拉美。这四项参与研究已经招募了8,480个儿童白血病病例和4,462例对照， 并收集了大量的环境/遗传数据和生物测量，提供了最全面的 全球拉丁人种群的资源。单独或作为儿童期癌症和白血病的一部分 财团（CLIC），这些研究产生了开创性发现，记录了儿童期的产前。 白血病并确定许多导致疾病风险增加或降低的因素 化学暴露，饮食/维生素，母乳喂养，免疫反应，出生体重和遗传因素。这 维护这些资源并需要增强数据共享程序以有效 扩大儿童白血病的持续病因学和肿瘤生物学研究，尤其是髓样亚型 在拉丁裔中更常见，并且发现白血病风险和结果的差异来源。实现我们的 目标，我们计划（1）使用可互操作的管理系统REDCAP来为 研究资源的管理，协调，存储和共享； （2）通过 将有关潜在致癌剂/混合物的暴露与人口级数据库进行联系 社会/建筑环境； （3）与CLIC财团在国内和国际上促进更广泛的数据使用， （4）扩大社区与公众，外行卫生工作者和美国卫生专业人员的参与 和拉丁美洲国家，以提高人们对儿童白血病的可预防危险因素的认识。