Exposure to per- and polyfluoroalkyl substances (PFAS) and risk of cancer in children

接触全氟烷基物质和多氟烷基物质 (PFAS) 与儿童患癌症的风险

• 批准号: 10678857
• 负责人: Catherine Metayer
• 金额: $ 63.02万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-03 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10678857
• 关键词: Accidents; Accounting; Adolescent; Adult; Age; Archives; Area; Attention; Biological Markers; Biological Monitoring; Birth; Blood; Blood specimen; Body Burden; Breast Feeding; Calibration; California; Cancer Cluster; Central Nervous System; Chemicals; Child; Childhood Leukemia; Communities; County; Data; Diet; Drug Kinetics; Dryness; Dust; Environment; Environmental Engineering technology; Environmental Health; Ethnic Origin; Exposure to; Food; Geographic Locations; Health; Home; House Dust; Human; Infant; Ingestion; Institution; Intake; Kidney; Knowledge; Laboratories; Life; Link; Los Angeles; Lymphoma; Malignant Childhood Neoplasm; Malignant Neoplasms; Malignant neoplasm of brain; Measurement; Measures; Methodology; Methods; Modeling; Mothers; Needs Assessment; Neonatal; Newborn Infant; Oranges; Outcome; Participant; Pediatric epidemiology; Phase; Poly-fluoroalkyl substances; Population; Pregnancy; Race; Renal carcinoma; Reporting; Research; Research Personnel; Residential Mobility; Resources; Rhabdomyosarcoma; Risk; Risk Estimate; Route; Sampling; Serum; Site; Spottings; Statistical Data Interpretation; Testing; Testis; Thyroid Gland; Translational Research; Universities; Water; age group; analytical method; cancer epidemiology; cancer risk; cancer site; case control; contaminated drinking water; contaminated water; design; drinking water; early childhood; early life exposure; early onset; epidemiology study; exposure route; high risk; improved; innovation; leukemia; manufacture; novel; older patient; pharmacokinetic model; postnatal; prenatal; prenatal exposure; programs; residence; screening; sex; synergism; virtual

PROJECT SUMMARY/ABSTRACT Per- and polyfluoroalkyl substances (PFAS) have been used in many manufacturing and commercial products in recent decades, resulting in widespread and persistent contamination despite the phasing out of early compounds such as PFOS and PFOA. Routes of PFAS exposure to humans vary by age; while exposures in infants and children are commonly from breastfeeding and ingestion of settled dust, adolescents and adults are primarily exposed through food and water. PFAS have been associated with several adverse health outcomes, including cancer in adults. Despite several reports of childhood cancer clusters in PFAS-contaminated areas, and potentially higher body burdens in children compared to adults, no studies have systematically assessed cancer risk in children, due, in part to the relative rarity of childhood cancer. We propose to conduct the first study of PFAS and cancer in children, by integrating the expertise of investigators from four institutions, forming a transdisciplinary virtual consortium with expertise in pediatric and cancer epidemiology, and environmental engineering and health sciences. Using innovative methodology, this virtual consortium will characterize PFAS from the most relevant routes of exposure by examining PFAS in drinking water (Aim 1), newborn and pregnancy blood samples (Aim 2), and household dust (Aim 3) during vulnerable exposure windows from pregnancy through early childhood, and subsequent risk of developing childhood cancer. We will focus on cancers that have been reported previously in communities and groups known to have high exposures to PFAS, such as leukemia, rhabdomyosarcoma, lymphoma, and cancers of the brain, central nervous system, kidney, testis, and thyroid. We will leverage two existing California childhood cancer studies with complementary designs offering large number of childhood cancer cases and controls with residential information, and with access to blood and dust samples for subsets. PFAS water exposure assessment, we will use a Bayesian pharmacokinetic calibration approach that combines measured drinking water concentrations with measured serum biomarkers to provide improved exposure estimates. We will also combine targeted and non-targeted mass spectrometric strategies to measure PFAS in blood and dust samples. There will be synergy between the three research aims by overlapping study participants (Aims 1 and 2), coordinating laboratory analyses (Aims 2 and 3) and statistical analyses (Aims 1, 2, 3), and by paying special attention to leukemia--the most common childhood cancer (Aims 1, 2, 3). The ViCTER Consortium will be supported by an Administrative and Scientific Oversight Core to coordinate and integrate resources and activities of the three research aims. With our unique resources, novel methods, and complementary expertise, this proposal responds to the urgent need of assessing population cancer risk to children related to PFAS.

项目摘要/摘要 全氟烷基和多氟烷基物质(PFAS)已用于许多制造和商业产品 近几十年来，尽管早期逐步淘汰，但仍造成广泛和持续的污染 全氟辛烷磺酸和全氟辛酸等化合物。人类接触全氟辛烷磺酸的途径因年龄而异；而在 婴幼儿一般由母乳喂养和摄取尘埃，青少年和成年人则 主要通过食物和水暴露。全氟辛烷磺酸与几种不利的健康后果有关， 包括成年人的癌症。尽管有几份关于全氟辛烷磺酸污染地区儿童癌症聚集性的报道， 与成人相比，儿童的身体负担可能更高，目前还没有研究系统地评估 儿童患癌症的风险，部分原因是儿童癌症相对罕见。我们建议进行第一次 通过整合来自四个机构的研究人员的专业知识，研究PFAS与儿童癌症，形成 一个跨学科的虚拟联盟，拥有儿科和癌症流行病学以及环境方面的专业知识 工程和健康科学。使用创新的方法，这个虚拟联盟将描述PFAS的特点 通过检查饮用水中的全氟辛烷磺酸(目标1)、新生儿和怀孕，从最相关的接触途径中 血样(目标2)和家庭粉尘(目标3)在从怀孕到 儿童早期，以及随后发展为儿童期癌症的风险。我们将把重点放在已经 以前在已知有高暴露于全氟辛烷磺酸的社区和群体，如白血病， 横纹肌肉瘤、淋巴瘤、脑癌、中枢神经系统癌、肾癌、睾丸癌和甲状腺癌。 我们将利用加州现有的两项儿童癌症研究，它们具有互补的设计，提供 儿童癌症病例和对照数量，有居住信息，有接触血液和灰尘的机会 子集的样本。PFAS水暴露评估，我们将使用贝叶斯药代动力学校准 将测量的饮用水浓度与测量的血清生物标志物相结合的方法，以提供 改进了风险暴露估计。我们还将结合定向和非定向质谱学策略来 测量血液和粉尘样本中的全氟辛烷磺酸。三个研究目标之间将通过以下方式实现协同 重叠研究参与者(目标1和2)、协调实验室分析(目标2和3)和统计 分析(AIMS 1、2、3)，并特别关注白血病--最常见的儿童癌症(AIMS 1、2、3)。胜利者联盟将得到行政和科学监督核心的支持，以 协调和整合三个研究目标的资源和活动。凭借我们独特的资源，新奇 方法和互补的专门知识，这项建议回应了评估人口的迫切需要 与全氟辛烷磺酸有关的儿童癌症风险。

项目成果

Trace analysis of per- and polyfluorinated alkyl substances (PFAS) in dried blood spots - Demonstration of reproducibility and comparability to venous blood samples.

干血斑中全氟烷基物质和多氟烷基物质 (PFAS) 的痕量分析 - 证明静脉血样本的再现性和可比性。

• DOI: 10.1016/j.scitotenv.2023.163530
• 发表时间: 2023
• 期刊: The Science of the total environment
• 作者: Lin,ElizabethZ;Nason,SaraL;Zhong,Alexander;Fortner,John;GodriPollitt,KrystalJ
• 通讯作者: GodriPollitt,KrystalJ

Per- and polyfluoroalkyl substances (PFAS) and thyroid hormone measurements in dried blood spots and neonatal characteristics: a pilot study.

• DOI: 10.1038/s41370-023-00603-4
• 发表时间: 2023-09
• 期刊: Journal of exposure science & environmental epidemiology
• 影响因子: 4.5
• 作者: Rosen Vollmar AK;Lin EZ;Nason SL;Santiago K;Johnson CH;Ma X;Godri Pollitt KJ;Deziel NC
• 通讯作者: Deziel NC

Novel perfluoroalkyl substances (PFAS) discovered in whole blood using automated non-targeted analysis of dried blood spots.

通过对干血斑进行自动非靶向分析，在全血中发现了新型全氟烷基物质 (PFAS)。

• DOI: 10.1016/j.scitotenv.2023.163579
• 发表时间: 2023
• 期刊: The Science of the total environment
• 作者: Koelmel,JeremyP;Lin,ElizabethZ;Parry,Emily;Stelben,Paul;Rennie,EmmaE;GodriPollitt,KrystalJ
• 通讯作者: GodriPollitt,KrystalJ