Exposure to per- and polyfluoroalkyl substances (PFAS) and risk of cancer in children
接触全氟烷基物质和多氟烷基物质 (PFAS) 与儿童患癌症的风险
基本信息
- 批准号:10678857
- 负责人:
- 金额:$ 63.02万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-09-03 至 2024-08-31
- 项目状态:已结题
- 来源:
- 关键词:AccidentsAccountingAdolescentAdultAgeArchivesAreaAttentionBiological MarkersBiological MonitoringBirthBloodBlood specimenBody BurdenBreast FeedingCalibrationCaliforniaCancer ClusterCentral Nervous SystemChemicalsChildChildhood LeukemiaCommunitiesCountyDataDietDrug KineticsDrynessDustEnvironmentEnvironmental Engineering technologyEnvironmental HealthEthnic OriginExposure toFoodGeographic LocationsHealthHomeHouse DustHumanInfantIngestionInstitutionIntakeKidneyKnowledgeLaboratoriesLifeLinkLos AngelesLymphomaMalignant Childhood NeoplasmMalignant NeoplasmsMalignant neoplasm of brainMeasurementMeasuresMethodologyMethodsModelingMothersNeeds AssessmentNeonatalNewborn InfantOrangesOutcomeParticipantPediatric epidemiologyPhasePoly-fluoroalkyl substancesPopulationPregnancyRaceRenal carcinomaReportingResearchResearch PersonnelResidential MobilityResourcesRhabdomyosarcomaRiskRisk EstimateRouteSamplingSerumSiteSpottingsStatistical Data InterpretationTestingTestisThyroid GlandTranslational ResearchUniversitiesWaterage groupanalytical methodcancer epidemiologycancer riskcancer sitecase controlcontaminated drinking watercontaminated waterdesigndrinking waterearly childhoodearly life exposureearly onsetepidemiology studyexposure routehigh riskimprovedinnovationleukemiamanufacturenovelolder patientpharmacokinetic modelpostnatalprenatalprenatal exposureprogramsresidencescreeningsexsynergismvirtual
项目摘要
PROJECT SUMMARY/ABSTRACT
Per- and polyfluoroalkyl substances (PFAS) have been used in many manufacturing and commercial products
in recent decades, resulting in widespread and persistent contamination despite the phasing out of early
compounds such as PFOS and PFOA. Routes of PFAS exposure to humans vary by age; while exposures in
infants and children are commonly from breastfeeding and ingestion of settled dust, adolescents and adults are
primarily exposed through food and water. PFAS have been associated with several adverse health outcomes,
including cancer in adults. Despite several reports of childhood cancer clusters in PFAS-contaminated areas,
and potentially higher body burdens in children compared to adults, no studies have systematically assessed
cancer risk in children, due, in part to the relative rarity of childhood cancer. We propose to conduct the first
study of PFAS and cancer in children, by integrating the expertise of investigators from four institutions, forming
a transdisciplinary virtual consortium with expertise in pediatric and cancer epidemiology, and environmental
engineering and health sciences. Using innovative methodology, this virtual consortium will characterize PFAS
from the most relevant routes of exposure by examining PFAS in drinking water (Aim 1), newborn and pregnancy
blood samples (Aim 2), and household dust (Aim 3) during vulnerable exposure windows from pregnancy through
early childhood, and subsequent risk of developing childhood cancer. We will focus on cancers that have been
reported previously in communities and groups known to have high exposures to PFAS, such as leukemia,
rhabdomyosarcoma, lymphoma, and cancers of the brain, central nervous system, kidney, testis, and thyroid.
We will leverage two existing California childhood cancer studies with complementary designs offering large
number of childhood cancer cases and controls with residential information, and with access to blood and dust
samples for subsets. PFAS water exposure assessment, we will use a Bayesian pharmacokinetic calibration
approach that combines measured drinking water concentrations with measured serum biomarkers to provide
improved exposure estimates. We will also combine targeted and non-targeted mass spectrometric strategies to
measure PFAS in blood and dust samples. There will be synergy between the three research aims by
overlapping study participants (Aims 1 and 2), coordinating laboratory analyses (Aims 2 and 3) and statistical
analyses (Aims 1, 2, 3), and by paying special attention to leukemia--the most common childhood cancer (Aims
1, 2, 3). The ViCTER Consortium will be supported by an Administrative and Scientific Oversight Core to
coordinate and integrate resources and activities of the three research aims. With our unique resources, novel
methods, and complementary expertise, this proposal responds to the urgent need of assessing population
cancer risk to children related to PFAS.
项目总结/摘要
全氟烷基和多氟烷基物质(PFAS)已用于许多制造和商业产品中
近几十年来,尽管早期淘汰,但仍导致广泛而持续的污染
例如PFOS和PFOA。PFAS暴露于人类的途径因年龄而异;
婴儿和儿童通常来自母乳喂养和摄入沉降的灰尘,青少年和成年人
主要通过食物和水接触。PFAS与几种不良健康结果有关,
包括成年人的癌症尽管有几份关于PFAS污染地区儿童癌症集群的报告,
儿童的身体负担可能比成人高,没有研究系统地评估
儿童癌症风险,部分原因是儿童癌症相对罕见。我们建议进行第一次
PFAS和儿童癌症的研究,通过整合来自四个机构的研究人员的专业知识,
一个跨学科的虚拟联盟,在儿科和癌症流行病学和环境方面拥有专业知识,
工程和健康科学。该虚拟联盟将使用创新方法来描述PFAS的特征
通过检查饮用水(目标1)、新生儿和妊娠中的全氟辛烷磺酸,
血液样本(目标2)和家庭灰尘(目标3),从怀孕到
儿童早期,以及随后发生儿童癌症的风险。我们将重点关注癌症,
先前在已知高暴露于PFAS的社区和群体中报告,如白血病,
横纹肌肉瘤、淋巴瘤和脑癌、中枢神经系统癌、肾癌、睾丸癌和甲状腺癌。
我们将利用现有的两项加州儿童癌症研究,并采用互补设计,
儿童癌症病例数和有住所信息、可获得血液和灰尘的对照数
样本的子集。PFAS水暴露评估,我们将使用贝叶斯药代动力学校准
一种将测量的饮用水浓度与测量的血清生物标志物相结合的方法,
改进暴露估计。我们还将结合联合收割机靶向和非靶向质谱策略,
测量血液和灰尘样本中的PFAS。这三个研究目标之间将有协同作用,
重叠研究受试者(目的1和2),协调实验室分析(目的2和3)和统计
分析(目标1,2,3),并特别关注白血病-最常见的儿童癌症(目标
1、2、3)。ViCTER联盟将得到行政和科学监督核心的支持,
协调和整合三个研究目标的资源和活动。凭借我们独特的资源,
方法和互补的专门知识,这项建议响应了评估人口的迫切需要,
与PFAS相关的儿童癌症风险。
项目成果
期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Trace analysis of per- and polyfluorinated alkyl substances (PFAS) in dried blood spots - Demonstration of reproducibility and comparability to venous blood samples.
干血斑中全氟烷基物质和多氟烷基物质 (PFAS) 的痕量分析 - 证明静脉血样本的再现性和可比性。
- DOI:10.1016/j.scitotenv.2023.163530
- 发表时间:2023
- 期刊:
- 影响因子:0
- 作者:Lin,ElizabethZ;Nason,SaraL;Zhong,Alexander;Fortner,John;GodriPollitt,KrystalJ
- 通讯作者:GodriPollitt,KrystalJ
Per- and polyfluoroalkyl substances (PFAS) and thyroid hormone measurements in dried blood spots and neonatal characteristics: a pilot study.
- DOI:10.1038/s41370-023-00603-4
- 发表时间:2023-09
- 期刊:
- 影响因子:4.5
- 作者:Rosen Vollmar AK;Lin EZ;Nason SL;Santiago K;Johnson CH;Ma X;Godri Pollitt KJ;Deziel NC
- 通讯作者:Deziel NC
Novel perfluoroalkyl substances (PFAS) discovered in whole blood using automated non-targeted analysis of dried blood spots.
通过对干血斑进行自动非靶向分析,在全血中发现了新型全氟烷基物质 (PFAS)。
- DOI:10.1016/j.scitotenv.2023.163579
- 发表时间:2023
- 期刊:
- 影响因子:0
- 作者:Koelmel,JeremyP;Lin,ElizabethZ;Parry,Emily;Stelben,Paul;Rennie,EmmaE;GodriPollitt,KrystalJ
- 通讯作者:GodriPollitt,KrystalJ
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Catherine Metayer其他文献
Catherine Metayer的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Catherine Metayer', 18)}}的其他基金
Fetal Origins of Testicular Cancer: A Metabolomics Study in Newborns
睾丸癌的胎儿起源:新生儿代谢组学研究
- 批准号:
10426083 - 财政年份:2021
- 资助金额:
$ 63.02万 - 项目类别:
Exposure to per- and polyfluoroalkyl substances (PFAS) and risk of cancer in children
接触全氟烷基物质和多氟烷基物质 (PFAS) 与儿童患癌症的风险
- 批准号:
10310918 - 财政年份:2021
- 资助金额:
$ 63.02万 - 项目类别:
Support for Infrastructure of Childhood Leukemia Environmental Research
支持儿童白血病环境研究基础设施
- 批准号:
10172904 - 财政年份:2017
- 资助金额:
$ 63.02万 - 项目类别:
Support for Infrastructure of Childhood Leukemia Environmental Research
支持儿童白血病环境研究基础设施
- 批准号:
9385454 - 财政年份:2017
- 资助金额:
$ 63.02万 - 项目类别:
Support For Infrastructure of Childhood Leukemia Environmental Research
支持儿童白血病环境研究基础设施
- 批准号:
10588560 - 财政年份:2017
- 资助金额:
$ 63.02万 - 项目类别:
Childhood Leukemia International Consortium Scientific Annual Meetings
儿童白血病国际联盟科学年会
- 批准号:
9131744 - 财政年份:2015
- 资助金额:
$ 63.02万 - 项目类别:
Childhood Leukemia International Consortium Scientific Annual Meetings
儿童白血病国际联盟科学年会
- 批准号:
9052516 - 财政年份:2015
- 资助金额:
$ 63.02万 - 项目类别:
Childhood Leukemia International Consortium Scientific Annual Meetings
儿童白血病国际联盟科学年会
- 批准号:
9418611 - 财政年份:2015
- 资助金额:
$ 63.02万 - 项目类别:
Perinatal hormonal biomarkers and risk of testicular germ cell tumors
围产期激素生物标志物和睾丸生殖细胞肿瘤的风险
- 批准号:
8926913 - 财政年份:2014
- 资助金额:
$ 63.02万 - 项目类别:
2014 Childhood Leukemia International Consortium Annual Scientific Meeting
2014年儿童白血病国际联盟科学年会
- 批准号:
8783942 - 财政年份:2014
- 资助金额:
$ 63.02万 - 项目类别:
相似海外基金
Unraveling the Dynamics of International Accounting: Exploring the Impact of IFRS Adoption on Firms' Financial Reporting and Business Strategies
揭示国际会计的动态:探索采用 IFRS 对公司财务报告和业务战略的影响
- 批准号:
24K16488 - 财政年份:2024
- 资助金额:
$ 63.02万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Mighty Accounting - Accountancy Automation for 1-person limited companies.
Mighty Accounting - 1 人有限公司的会计自动化。
- 批准号:
10100360 - 财政年份:2024
- 资助金额:
$ 63.02万 - 项目类别:
Collaborative R&D
Accounting for the Fall of Silver? Western exchange banking practice, 1870-1910
白银下跌的原因是什么?
- 批准号:
24K04974 - 财政年份:2024
- 资助金额:
$ 63.02万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
A New Direction in Accounting Education for IT Human Resources
IT人力资源会计教育的新方向
- 批准号:
23K01686 - 财政年份:2023
- 资助金额:
$ 63.02万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
An empirical and theoretical study of the double-accounting system in 19th-century American and British public utility companies
19世纪美国和英国公用事业公司双重会计制度的实证和理论研究
- 批准号:
23K01692 - 财政年份:2023
- 资助金额:
$ 63.02万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
An Empirical Analysis of the Value Effect: An Accounting Viewpoint
价值效应的实证分析:会计观点
- 批准号:
23K01695 - 财政年份:2023
- 资助金额:
$ 63.02万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Accounting model for improving performance on the health and productivity management
提高健康和生产力管理绩效的会计模型
- 批准号:
23K01713 - 财政年份:2023
- 资助金额:
$ 63.02万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
CPS: Medium: Making Every Drop Count: Accounting for Spatiotemporal Variability of Water Needs for Proactive Scheduling of Variable Rate Irrigation Systems
CPS:中:让每一滴水都发挥作用:考虑用水需求的时空变化,主动调度可变速率灌溉系统
- 批准号:
2312319 - 财政年份:2023
- 资助金额:
$ 63.02万 - 项目类别:
Standard Grant
New Role of Not-for-Profit Entities and Their Accounting Standards to Be Unified
非营利实体的新角色及其会计准则将统一
- 批准号:
23K01715 - 财政年份:2023
- 资助金额:
$ 63.02万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Improving Age- and Cause-Specific Under-Five Mortality Rates (ACSU5MR) by Systematically Accounting Measurement Errors to Inform Child Survival Decision Making in Low Income Countries
通过系统地核算测量误差来改善特定年龄和特定原因的五岁以下死亡率 (ACSU5MR),为低收入国家的儿童生存决策提供信息
- 批准号:
10585388 - 财政年份:2023
- 资助金额:
$ 63.02万 - 项目类别: