Exposure to per- and polyfluoroalkyl substances (PFAS) and risk of cancer in children
接触全氟烷基物质和多氟烷基物质 (PFAS) 与儿童患癌症的风险
基本信息
- 批准号:10678857
- 负责人:
- 金额:$ 63.02万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-09-03 至 2024-08-31
- 项目状态:已结题
- 来源:
- 关键词:AccidentsAccountingAdolescentAdultAgeArchivesAreaAttentionBiological MarkersBiological MonitoringBirthBloodBlood specimenBody BurdenBreast FeedingCalibrationCaliforniaCancer ClusterCentral Nervous SystemChemicalsChildChildhood LeukemiaCommunitiesCountyDataDietDrug KineticsDrynessDustEnvironmentEnvironmental Engineering technologyEnvironmental HealthEthnic OriginExposure toFoodGeographic LocationsHealthHomeHouse DustHumanInfantIngestionInstitutionIntakeKidneyKnowledgeLaboratoriesLifeLinkLos AngelesLymphomaMalignant Childhood NeoplasmMalignant NeoplasmsMalignant neoplasm of brainMeasurementMeasuresMethodologyMethodsModelingMothersNeeds AssessmentNeonatalNewborn InfantOrangesOutcomeParticipantPediatric epidemiologyPhasePoly-fluoroalkyl substancesPopulationPregnancyRaceRenal carcinomaReportingResearchResearch PersonnelResidential MobilityResourcesRhabdomyosarcomaRiskRisk EstimateRouteSamplingSerumSiteSpottingsStatistical Data InterpretationTestingTestisThyroid GlandTranslational ResearchUniversitiesWaterage groupanalytical methodcancer epidemiologycancer riskcancer sitecase controlcontaminated drinking watercontaminated waterdesigndrinking waterearly childhoodearly life exposureearly onsetepidemiology studyexposure routehigh riskimprovedinnovationleukemiamanufacturenovelolder patientpharmacokinetic modelpostnatalprenatalprenatal exposureprogramsresidencescreeningsexsynergismvirtual
项目摘要
PROJECT SUMMARY/ABSTRACT
Per- and polyfluoroalkyl substances (PFAS) have been used in many manufacturing and commercial products
in recent decades, resulting in widespread and persistent contamination despite the phasing out of early
compounds such as PFOS and PFOA. Routes of PFAS exposure to humans vary by age; while exposures in
infants and children are commonly from breastfeeding and ingestion of settled dust, adolescents and adults are
primarily exposed through food and water. PFAS have been associated with several adverse health outcomes,
including cancer in adults. Despite several reports of childhood cancer clusters in PFAS-contaminated areas,
and potentially higher body burdens in children compared to adults, no studies have systematically assessed
cancer risk in children, due, in part to the relative rarity of childhood cancer. We propose to conduct the first
study of PFAS and cancer in children, by integrating the expertise of investigators from four institutions, forming
a transdisciplinary virtual consortium with expertise in pediatric and cancer epidemiology, and environmental
engineering and health sciences. Using innovative methodology, this virtual consortium will characterize PFAS
from the most relevant routes of exposure by examining PFAS in drinking water (Aim 1), newborn and pregnancy
blood samples (Aim 2), and household dust (Aim 3) during vulnerable exposure windows from pregnancy through
early childhood, and subsequent risk of developing childhood cancer. We will focus on cancers that have been
reported previously in communities and groups known to have high exposures to PFAS, such as leukemia,
rhabdomyosarcoma, lymphoma, and cancers of the brain, central nervous system, kidney, testis, and thyroid.
We will leverage two existing California childhood cancer studies with complementary designs offering large
number of childhood cancer cases and controls with residential information, and with access to blood and dust
samples for subsets. PFAS water exposure assessment, we will use a Bayesian pharmacokinetic calibration
approach that combines measured drinking water concentrations with measured serum biomarkers to provide
improved exposure estimates. We will also combine targeted and non-targeted mass spectrometric strategies to
measure PFAS in blood and dust samples. There will be synergy between the three research aims by
overlapping study participants (Aims 1 and 2), coordinating laboratory analyses (Aims 2 and 3) and statistical
analyses (Aims 1, 2, 3), and by paying special attention to leukemia--the most common childhood cancer (Aims
1, 2, 3). The ViCTER Consortium will be supported by an Administrative and Scientific Oversight Core to
coordinate and integrate resources and activities of the three research aims. With our unique resources, novel
methods, and complementary expertise, this proposal responds to the urgent need of assessing population
cancer risk to children related to PFAS.
项目总结/文摘
项目成果
期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Trace analysis of per- and polyfluorinated alkyl substances (PFAS) in dried blood spots - Demonstration of reproducibility and comparability to venous blood samples.
干血斑中全氟烷基物质和多氟烷基物质 (PFAS) 的痕量分析 - 证明静脉血样本的再现性和可比性。
- DOI:10.1016/j.scitotenv.2023.163530
- 发表时间:2023
- 期刊:
- 影响因子:0
- 作者:Lin,ElizabethZ;Nason,SaraL;Zhong,Alexander;Fortner,John;GodriPollitt,KrystalJ
- 通讯作者:GodriPollitt,KrystalJ
Per- and polyfluoroalkyl substances (PFAS) and thyroid hormone measurements in dried blood spots and neonatal characteristics: a pilot study.
- DOI:10.1038/s41370-023-00603-4
- 发表时间:2023-09
- 期刊:
- 影响因子:4.5
- 作者:Rosen Vollmar AK;Lin EZ;Nason SL;Santiago K;Johnson CH;Ma X;Godri Pollitt KJ;Deziel NC
- 通讯作者:Deziel NC
Novel perfluoroalkyl substances (PFAS) discovered in whole blood using automated non-targeted analysis of dried blood spots.
通过对干血斑进行自动非靶向分析,在全血中发现了新型全氟烷基物质 (PFAS)。
- DOI:10.1016/j.scitotenv.2023.163579
- 发表时间:2023
- 期刊:
- 影响因子:0
- 作者:Koelmel,JeremyP;Lin,ElizabethZ;Parry,Emily;Stelben,Paul;Rennie,EmmaE;GodriPollitt,KrystalJ
- 通讯作者:GodriPollitt,KrystalJ
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{{ truncateString('Catherine Metayer', 18)}}的其他基金
Fetal Origins of Testicular Cancer: A Metabolomics Study in Newborns
睾丸癌的胎儿起源:新生儿代谢组学研究
- 批准号:
10426083 - 财政年份:2021
- 资助金额:
$ 63.02万 - 项目类别:
Exposure to per- and polyfluoroalkyl substances (PFAS) and risk of cancer in children
接触全氟烷基物质和多氟烷基物质 (PFAS) 与儿童患癌症的风险
- 批准号:
10310918 - 财政年份:2021
- 资助金额:
$ 63.02万 - 项目类别:
Support for Infrastructure of Childhood Leukemia Environmental Research
支持儿童白血病环境研究基础设施
- 批准号:
10172904 - 财政年份:2017
- 资助金额:
$ 63.02万 - 项目类别:
Support for Infrastructure of Childhood Leukemia Environmental Research
支持儿童白血病环境研究基础设施
- 批准号:
9385454 - 财政年份:2017
- 资助金额:
$ 63.02万 - 项目类别:
Support For Infrastructure of Childhood Leukemia Environmental Research
支持儿童白血病环境研究基础设施
- 批准号:
10588560 - 财政年份:2017
- 资助金额:
$ 63.02万 - 项目类别:
Childhood Leukemia International Consortium Scientific Annual Meetings
儿童白血病国际联盟科学年会
- 批准号:
9131744 - 财政年份:2015
- 资助金额:
$ 63.02万 - 项目类别:
Childhood Leukemia International Consortium Scientific Annual Meetings
儿童白血病国际联盟科学年会
- 批准号:
9052516 - 财政年份:2015
- 资助金额:
$ 63.02万 - 项目类别:
Childhood Leukemia International Consortium Scientific Annual Meetings
儿童白血病国际联盟科学年会
- 批准号:
9418611 - 财政年份:2015
- 资助金额:
$ 63.02万 - 项目类别:
Perinatal hormonal biomarkers and risk of testicular germ cell tumors
围产期激素生物标志物和睾丸生殖细胞肿瘤的风险
- 批准号:
8926913 - 财政年份:2014
- 资助金额:
$ 63.02万 - 项目类别:
2014 Childhood Leukemia International Consortium Annual Scientific Meeting
2014年儿童白血病国际联盟科学年会
- 批准号:
8783942 - 财政年份:2014
- 资助金额:
$ 63.02万 - 项目类别:
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