Exposure to per- and polyfluoroalkyl substances (PFAS) and risk of cancer in children

接触全氟烷基物质和多氟烷基物质 (PFAS) 与儿童患癌症的风险

• 批准号: 10678857
• 负责人: Catherine Metayer
• 金额: $ 63.02万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-03 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10678857
• 关键词: Accidents; Accounting; Adolescent; Adult; Age; Archives; Area; Attention; Biological Markers; Biological Monitoring; Birth; Blood; Blood specimen; Body Burden; Breast Feeding; Calibration; California; Cancer Cluster; Central Nervous System; Chemicals; Child; Childhood Leukemia; Communities; County; Data; Diet; Drug Kinetics; Dryness; Dust; Environment; Environmental Engineering technology; Environmental Health; Ethnic Origin; Exposure to; Food; Geographic Locations; Health; Home; House Dust; Human; Infant; Ingestion; Institution; Intake; Kidney; Knowledge; Laboratories; Life; Link; Los Angeles; Lymphoma; Malignant Childhood Neoplasm; Malignant Neoplasms; Malignant neoplasm of brain; Measurement; Measures; Methodology; Methods; Modeling; Mothers; Needs Assessment; Neonatal; Newborn Infant; Oranges; Outcome; Participant; Pediatric epidemiology; Phase; Poly-fluoroalkyl substances; Population; Pregnancy; Race; Renal carcinoma; Reporting; Research; Research Personnel; Residential Mobility; Resources; Rhabdomyosarcoma; Risk; Risk Estimate; Route; Sampling; Serum; Site; Spottings; Statistical Data Interpretation; Testing; Testis; Thyroid Gland; Translational Research; Universities; Water; age group; analytical method; cancer epidemiology; cancer risk; cancer site; case control; contaminated drinking water; contaminated water; design; drinking water; early childhood; early life exposure; early onset; epidemiology study; exposure route; high risk; improved; innovation; leukemia; manufacture; novel; older patient; pharmacokinetic model; postnatal; prenatal; prenatal exposure; programs; residence; screening; sex; synergism; virtual

PROJECT SUMMARY/ABSTRACT Per- and polyfluoroalkyl substances (PFAS) have been used in many manufacturing and commercial products in recent decades, resulting in widespread and persistent contamination despite the phasing out of early compounds such as PFOS and PFOA. Routes of PFAS exposure to humans vary by age; while exposures in infants and children are commonly from breastfeeding and ingestion of settled dust, adolescents and adults are primarily exposed through food and water. PFAS have been associated with several adverse health outcomes, including cancer in adults. Despite several reports of childhood cancer clusters in PFAS-contaminated areas, and potentially higher body burdens in children compared to adults, no studies have systematically assessed cancer risk in children, due, in part to the relative rarity of childhood cancer. We propose to conduct the first study of PFAS and cancer in children, by integrating the expertise of investigators from four institutions, forming a transdisciplinary virtual consortium with expertise in pediatric and cancer epidemiology, and environmental engineering and health sciences. Using innovative methodology, this virtual consortium will characterize PFAS from the most relevant routes of exposure by examining PFAS in drinking water (Aim 1), newborn and pregnancy blood samples (Aim 2), and household dust (Aim 3) during vulnerable exposure windows from pregnancy through early childhood, and subsequent risk of developing childhood cancer. We will focus on cancers that have been reported previously in communities and groups known to have high exposures to PFAS, such as leukemia, rhabdomyosarcoma, lymphoma, and cancers of the brain, central nervous system, kidney, testis, and thyroid. We will leverage two existing California childhood cancer studies with complementary designs offering large number of childhood cancer cases and controls with residential information, and with access to blood and dust samples for subsets. PFAS water exposure assessment, we will use a Bayesian pharmacokinetic calibration approach that combines measured drinking water concentrations with measured serum biomarkers to provide improved exposure estimates. We will also combine targeted and non-targeted mass spectrometric strategies to measure PFAS in blood and dust samples. There will be synergy between the three research aims by overlapping study participants (Aims 1 and 2), coordinating laboratory analyses (Aims 2 and 3) and statistical analyses (Aims 1, 2, 3), and by paying special attention to leukemia--the most common childhood cancer (Aims 1, 2, 3). The ViCTER Consortium will be supported by an Administrative and Scientific Oversight Core to coordinate and integrate resources and activities of the three research aims. With our unique resources, novel methods, and complementary expertise, this proposal responds to the urgent need of assessing population cancer risk to children related to PFAS.

项目总结/文摘

项目成果

Trace analysis of per- and polyfluorinated alkyl substances (PFAS) in dried blood spots - Demonstration of reproducibility and comparability to venous blood samples.

干血斑中全氟烷基物质和多氟烷基物质 (PFAS) 的痕量分析 - 证明静脉血样本的再现性和可比性。

• DOI: 10.1016/j.scitotenv.2023.163530
• 发表时间: 2023
• 期刊: The Science of the total environment
• 作者: Lin,ElizabethZ;Nason,SaraL;Zhong,Alexander;Fortner,John;GodriPollitt,KrystalJ
• 通讯作者: GodriPollitt,KrystalJ

Per- and polyfluoroalkyl substances (PFAS) and thyroid hormone measurements in dried blood spots and neonatal characteristics: a pilot study.

• DOI: 10.1038/s41370-023-00603-4
• 发表时间: 2023-09
• 期刊: Journal of exposure science & environmental epidemiology
• 影响因子: 4.5
• 作者: Rosen Vollmar AK;Lin EZ;Nason SL;Santiago K;Johnson CH;Ma X;Godri Pollitt KJ;Deziel NC
• 通讯作者: Deziel NC

Novel perfluoroalkyl substances (PFAS) discovered in whole blood using automated non-targeted analysis of dried blood spots.

通过对干血斑进行自动非靶向分析，在全血中发现了新型全氟烷基物质 (PFAS)。

• DOI: 10.1016/j.scitotenv.2023.163579
• 发表时间: 2023
• 期刊: The Science of the total environment
• 作者: Koelmel,JeremyP;Lin,ElizabethZ;Parry,Emily;Stelben,Paul;Rennie,EmmaE;GodriPollitt,KrystalJ
• 通讯作者: GodriPollitt,KrystalJ