Perinatal hormonal biomarkers and risk of testicular germ cell tumors
围产期激素生物标志物和睾丸生殖细胞肿瘤的风险
基本信息
- 批准号:8926913
- 负责人:
- 金额:$ 17.07万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2014
- 资助国家:美国
- 起止时间:2014-09-12 至 2017-08-31
- 项目状态:已结题
- 来源:
- 关键词:Adolescent and Young AdultAdultAffectAgeAndrogensAnimal ModelApoptosisArchivesBiological AssayBiological MarkersBirthBloodBlood specimenCaliforniaCell Differentiation processCell ProliferationCell divisionChlorinated HydrocarbonsCryptorchidismDataDevelopmentDiagnosisEndocrine DisruptorsEnvironmental ExposureEnvironmental Risk FactorEpidemiologic StudiesEstradiolEstriolEstrogensEthnic OriginEthnic groupEtiologyExposure toFemaleFetusFollicle Stimulating HormoneGerm cell tumorGoalsGonadal Steroid HormonesGonadotropinsHealthHispanicsHistologicHistologyHormonalHormone useHormonesHypospadiasImmunoassayIncidenceInfantInfertilityKnowledgeLaboratoriesLifeLuteinizing HormoneMalignant Childhood NeoplasmMalignant NeoplasmsMalignant neoplasm of testisMeasurementMeasuresMediationMedicalMethodsNeonatalNewborn InfantNot Hispanic or LatinoObesityOrganPathway interactionsPatient Self-ReportPerinatalPerinatal ExposurePesticidesPilot ProjectsPlacentaPlayPopulation HeterogeneityPregnancyPropertyPubertyRaceReproductive HistoryRiskRisk FactorsRoleSeminomaSeriesSerumSpecimenSpottingsSurrogate MarkersTeratomaTesticular DiseasesTesticular Germ Cell TumorTestisTestosteroneTimeWhole BloodWithdrawalYolk Sac Tumoragedbasecarcinogenesiscase controldehydroepiandrosteroneearly onsetfetalgenetic risk factorgenetic varianthealth disparityhormone regulationhypothalamic pituitary gonadal axisliquid chromatography mass spectrometrymaleminority healthmortalitypeptide hormonepostnatalreproductiveresponsesteroid hormone
项目摘要
DESCRIPTION (provided by applicant): Testicular cancers (TC) are the most common cancers in adolescents and young adults, while rare in infants. TC incidence increased dramatically in the US the past 40 years. Compared to non-Hispanic Whites, the incidence and mortality rates are increasing more rapidly in Hispanics, worsening minority health disparities. TC is mostly germ cell tumors (TGCT) and the histologic types (seminomas vs. nonseminomas) vary with age. The risk factors of TGCT are poorly understood. A few conditions such as cryptorchidism contribute to TGCT risk, and genetic factors have been recently identified. Environmental factors remain important determinants of TGCT, as evidenced by the raise in incidence rates. Estrogens and androgens (also called steroid sex hormones) have a central role on the development of the testis, and may play a dominant role in the etiology of TGCT, either directly or via mediation by exposure to endocrine disrupting chemicals such as organochlorines present in pesticides. Because of its early onset, TGCT are likely to develop during pregnancy, a period when the male fetus is exposed to high levels of steroid sex hormones. Another critical window for the development of TGCT may be the transition from intra-uterine to extra-uterine life, which is marked by an abrupt withdrawal of maternal hormones and a postnatal surge of the newborns' own steroid sex hormones and other regulatory hormones such as gonadotropins. Assessing the potential role of perinatal sex hormones, including the timing of exposure, in TGCT has proven challenging, mainly due to difficulties in obtaining pre-diagnosis, perinatal biospecimens. The objective of our proposed exploratory study is to provide preliminary data on birth hormone levels in California-born males diagnosed with TGCT from 1988 and 2009 (150 cases aged 15-19 years and 50 cases aged 0-4 years) and 200 age/ethnicity-matched controls. We will use archived dried bloodspot (DBS) specimens collected at birth and available to us through the California Childhood Cancer Record Linkage Project (CCRLP). Robust laboratory methods (i.e., liquid chromatography- mass spectrometry and immunoassays) are available to measure steroid sex hormones (i.e., estrone, estradiol, estriol, testosterone, and dehydroepiandrosterone) and gonadotropins (i.e., luteinizing hormone and follicle-stimulating hormone) in DBS specimens. Hormone levels will be compared between cases and controls overall, and by age, histologic, and ethnic group. Our proposed exploratory biomarker study will be a key step towards filling gaps in the current knowledge of TGCT etiology in non-Hispanic Whites and Hispanics, as well as quantifying sex hormone levels at birth that may be involved in other testicular conditions including infertility.
描述(由申请人提供):睾丸癌(TC)是青少年和年轻人中最常见的癌症,而在婴儿中罕见。过去40年来,美国的TC发病率急剧增加。与非西班牙裔白人相比,西班牙裔白人的发病率和死亡率增长更快,加剧了少数民族的健康差距。TC主要是生殖细胞肿瘤(TGCT),组织学类型(腺瘤与非腺瘤)随年龄而变化。TGCT的危险因素知之甚少。一些条件,如隐睾有助于TGCT的风险,遗传因素最近已被确定。环境因素仍然是TGCT的重要决定因素,发病率的上升就是明证。雌激素和雄激素(也称为类固醇性激素)对睾丸的发育具有核心作用,并且可能在TGCT的病因学中起主导作用,直接或通过暴露于内分泌干扰化学品(如农药中存在的有机氯)而介导。由于其早期发病,TGCT很可能在怀孕期间发展,这是一个男性胎儿暴露于高水平类固醇性激素的时期。TGCT发展的另一个关键窗口可能是从子宫内到子宫外生活的过渡,其特征是母体激素的突然撤回和新生儿自身类固醇性激素和其他调节激素如促性腺激素的出生后激增。评估围产期性激素的潜在作用,包括暴露的时间,在TGCT已被证明是具有挑战性的,主要是由于难以获得诊断前,围产期生物标本。我们提出的探索性研究的目的是提供1988年和2009年(150例年龄为15-19岁和50例年龄为0-4岁)加利福尼亚出生的男性诊断为TGCT的出生激素水平的初步数据,以及200例年龄/种族匹配的对照。我们将使用出生时采集的存档干血斑(DBS)标本,并通过加州儿童癌症记录链接项目(CCRLP)提供给我们。稳健的实验室方法(即,液相色谱-质谱法和免疫测定法)可用于测量类固醇性激素(即,雌酮、雌二醇、雌三醇、睾酮和脱氢表雄酮)和促性腺激素(即,促黄体激素和促卵泡激素)。激素水平将在病例和对照组之间进行比较,并按年龄、组织学和种族组进行比较。我们提出的探索性生物标志物研究将是填补目前非西班牙裔白人和西班牙裔TGCT病因学知识空白的关键一步,以及量化出生时可能涉及其他睾丸疾病(包括不孕症)的性激素水平。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Catherine Metayer其他文献
Catherine Metayer的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Catherine Metayer', 18)}}的其他基金
Exposure to per- and polyfluoroalkyl substances (PFAS) and risk of cancer in children
接触全氟烷基物质和多氟烷基物质 (PFAS) 与儿童患癌症的风险
- 批准号:
10678857 - 财政年份:2021
- 资助金额:
$ 17.07万 - 项目类别:
Fetal Origins of Testicular Cancer: A Metabolomics Study in Newborns
睾丸癌的胎儿起源:新生儿代谢组学研究
- 批准号:
10426083 - 财政年份:2021
- 资助金额:
$ 17.07万 - 项目类别:
Exposure to per- and polyfluoroalkyl substances (PFAS) and risk of cancer in children
接触全氟烷基物质和多氟烷基物质 (PFAS) 与儿童患癌症的风险
- 批准号:
10310918 - 财政年份:2021
- 资助金额:
$ 17.07万 - 项目类别:
Support for Infrastructure of Childhood Leukemia Environmental Research
支持儿童白血病环境研究基础设施
- 批准号:
10172904 - 财政年份:2017
- 资助金额:
$ 17.07万 - 项目类别:
Support for Infrastructure of Childhood Leukemia Environmental Research
支持儿童白血病环境研究基础设施
- 批准号:
9385454 - 财政年份:2017
- 资助金额:
$ 17.07万 - 项目类别:
Support For Infrastructure of Childhood Leukemia Environmental Research
支持儿童白血病环境研究基础设施
- 批准号:
10588560 - 财政年份:2017
- 资助金额:
$ 17.07万 - 项目类别:
Childhood Leukemia International Consortium Scientific Annual Meetings
儿童白血病国际联盟科学年会
- 批准号:
9131744 - 财政年份:2015
- 资助金额:
$ 17.07万 - 项目类别:
Childhood Leukemia International Consortium Scientific Annual Meetings
儿童白血病国际联盟科学年会
- 批准号:
9052516 - 财政年份:2015
- 资助金额:
$ 17.07万 - 项目类别:
Childhood Leukemia International Consortium Scientific Annual Meetings
儿童白血病国际联盟科学年会
- 批准号:
9418611 - 财政年份:2015
- 资助金额:
$ 17.07万 - 项目类别:
2014 Childhood Leukemia International Consortium Annual Scientific Meeting
2014年儿童白血病国际联盟科学年会
- 批准号:
8783942 - 财政年份:2014
- 资助金额:
$ 17.07万 - 项目类别:
相似海外基金
Co-designing a lifestyle, stop-vaping intervention for ex-smoking, adult vapers (CLOVER study)
为戒烟的成年电子烟使用者共同设计生活方式、戒烟干预措施(CLOVER 研究)
- 批准号:
MR/Z503605/1 - 财政年份:2024
- 资助金额:
$ 17.07万 - 项目类别:
Research Grant
Early Life Antecedents Predicting Adult Daily Affective Reactivity to Stress
早期生活经历预测成人对压力的日常情感反应
- 批准号:
2336167 - 财政年份:2024
- 资助金额:
$ 17.07万 - 项目类别:
Standard Grant
RAPID: Affective Mechanisms of Adjustment in Diverse Emerging Adult Student Communities Before, During, and Beyond the COVID-19 Pandemic
RAPID:COVID-19 大流行之前、期间和之后不同新兴成人学生社区的情感调整机制
- 批准号:
2402691 - 财政年份:2024
- 资助金额:
$ 17.07万 - 项目类别:
Standard Grant
Migrant Youth and the Sociolegal Construction of Child and Adult Categories
流动青年与儿童和成人类别的社会法律建构
- 批准号:
2341428 - 财政年份:2024
- 资助金额:
$ 17.07万 - 项目类别:
Standard Grant
Elucidation of Adult Newt Cells Regulating the ZRS enhancer during Limb Regeneration
阐明成体蝾螈细胞在肢体再生过程中调节 ZRS 增强子
- 批准号:
24K12150 - 财政年份:2024
- 资助金额:
$ 17.07万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Understanding how platelets mediate new neuron formation in the adult brain
了解血小板如何介导成人大脑中新神经元的形成
- 批准号:
DE240100561 - 财政年份:2024
- 资助金额:
$ 17.07万 - 项目类别:
Discovery Early Career Researcher Award
RUI: Evaluation of Neurotrophic-Like properties of Spaetzle-Toll Signaling in the Developing and Adult Cricket CNS
RUI:评估发育中和成年蟋蟀中枢神经系统中 Spaetzle-Toll 信号传导的神经营养样特性
- 批准号:
2230829 - 财政年份:2023
- 资助金额:
$ 17.07万 - 项目类别:
Standard Grant
Usefulness of a question prompt sheet for onco-fertility in adolescent and young adult patients under 25 years old.
问题提示表对于 25 岁以下青少年和年轻成年患者的肿瘤生育力的有用性。
- 批准号:
23K09542 - 财政年份:2023
- 资助金额:
$ 17.07万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Identification of new specific molecules associated with right ventricular dysfunction in adult patients with congenital heart disease
鉴定与成年先天性心脏病患者右心室功能障碍相关的新特异性分子
- 批准号:
23K07552 - 财政年份:2023
- 资助金额:
$ 17.07万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Issue identifications and model developments in transitional care for patients with adult congenital heart disease.
成人先天性心脏病患者过渡护理的问题识别和模型开发。
- 批准号:
23K07559 - 财政年份:2023
- 资助金额:
$ 17.07万 - 项目类别:
Grant-in-Aid for Scientific Research (C)