2014 Childhood Leukemia International Consortium Annual Scientific Meeting

描述（由申请人提供） 白血病是儿童中最常见的癌症。然而，这种疾病的相对罕见性使得环境和遗传风险因素的研究具有挑战性。2007年，来自10个国家的独立国际研究人员成立了儿童白血病国际联盟（CLIC），以克服单个研究的局限性，并支持联合研究项目，以调查儿童白血病的病因。 截至2013年11月，CLIC包括来自全球17个国家的33项儿童白血病病例对照研究（24名主要研究者），代表约38，000例病例和262，000例对照（其中约一半具有全面的流行病学数据和生物标本）。 CLIC联盟的年度会议为CLIC研究人员和其他成员提供了一个重要的机会，讨论正在进行的合作分析，概述新的研究方向，并开发未来的项目。它们还为建立和加强不同国家研究人员之间的同事工作关系提供了一个论坛。因此，CLIC在过去七年中非常成功地进行了九次环境和遗传因素的汇总分析（2013年又提出了十个项目），并为建立可持续的中央数据库制定了初步步骤。CLIC数据中心目前设在里昂（法国）的国际癌症研究机构（IARC），对于维护协调一致的数据和文件以及有效开展未来的CLIC研究至关重要。为了继续支持CLIC的研究和基础设施议程，我们建议每年举行CLIC会议。 具体而言，2014年CLIC科学会议的主要目标是为每个CLIC兴趣小组设定新的研究方向和优先事项。次要目标是为成员（高级和初级研究者）提供面对面的工作会议，以就9项当前分析和10项拟议的汇总分析进行合作。这些分析的大部分准备工作是在这些面对面的会议上进行的;然而，大多数CLIC成员没有得到充分的资金来开展CLIC活动，这阻碍了定期交流意见。第三个目标是讨论建立CLIC数据中心的进展情况、数据共享程序以及与统一研究变量有关的具体问题。第四个目标是提供并参与流行病学，肿瘤生物学，生物统计学和其他与儿童白血病研究相关学科的专家的教育演讲。

DESCRIPTION (provided by applicant) Leukemia is the most commonly occurring cancer among children. However, the relative rarity of the disease makes the study of the environmental and genetic risk factors challenging. A group of independent, international researchers from ten countries established the Childhood Leukemia International Consortium (CLIC) in 2007 to overcome the limitations of individual studies, and support combined research projects to investigate the etiology of childhood leukemia. As of November 2013, CLIC comprise of 33 childhood leukemia case-control studies worldwide from 17 countries (24 principal investigators) representing approximately 38,000 cases and 262,000 controls (about half of which have comprehensive epidemiologic data and biospecimens). The annual in person meetings of the CLIC consortium provide an important opportunity for CLIC investigators and other members, to discuss ongoing collaborative analyses, outline new research directions, and develop future projects. They also provide a forum for building and strengthening collegial working relationships among researchers from different countries. As a result, CLIC has been extremely successful over the past seven years in conducting nine ongoing pooled analyses of environmental and genetic factors (ten additional projects have been proposed in 2013) and in setting the preliminary steps for establishing a sustainable central data repository. The CLIC Data Center, which is currently hosted at the International Agency for Research on Cancer (IARC), in Lyon (France) is critical to maintain harmonized data and documentation, and to efficiently conduct future CLIC studies. In order to continue the support the CLIC research and infrastructure agenda, we propose to hold CLIC meetings annually. Specifically, the primary objective of the 2014 CLIC Scientific Meeting is to set new research directions and priorities for each of the CLIC Interest Groups. The secondary objective is to provide in-person working sessions for members (senior and junior investigators) to collaborate on nine current and ten proposed pooled analyses. Much of the preparatory work for these analyses is conducted in these in-person meetings; however, most of the CLIC members are not fully funded to work on CLIC activities, which impede regular exchange of ideas. The third objective is to discuss progress for the establishment of the CLIC Data Center, data sharing procedures, and specific issues related to harmonization study variables. The fourth objective is to provide and engage in educational presentations with experts in epidemiology, tumor biology, biostatistics, and other disciplines relevant to childhood leukemia research.