Following the Sound of Music - Comparing the Effects of Music vs. Non-Music Based Interventions on Auditory and Cognitive Processing in Older Adults

跟随音乐之声 - 比较音乐与非音乐干预对老年人听觉和认知处理的影响

• 批准号: 10273909
• 负责人: Susanne M Jaeggi
• 金额: $ 53.62万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-30 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10273909
• 关键词: Active Listening; Address; Age-associated memory impairment; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Apple; Attention; Auditory; Automobile Driving; Brain; Clinical Trials; Cognition; Cognitive; Cognitive aging; Collaborations; Communication; Data; Development; Dose; Effectiveness; Elderly; Environment; Frustration; Future; Goals; Health; Home; Impaired cognition; Individual; Intervention; Knowledge; Lead; Long-Term Effects; Measures; Mediating; Memory; Mission; Moods; Music; National Institute of Drug Abuse; National Institute of Mental Health; National Institute of Neurological Disorders and Stroke; National Institute on Alcohol Abuse and Alcoholism; Outcome; Outcome Measure; Outpatients; Performance; Personal Satisfaction; Phase; Population; Presbycusis; Prevention; Process; Psyche structure; Public Health; Quality of life; Randomized Controlled Trials; Reporting; Research; Resources; Risk; Short-Term Memory; Social Interaction; Social isolation; Speech; Stimulus; Target Populations; Taxes; Testing; Training; United States National Institutes of Health; Well in self; Work; acceptability and feasibility; active control; age effect; age related; arm; auditory processing; base; cognitive ability; cognitive function; cognitive process; cognitive skill; cost effective; cost effective intervention; disability burden; evidence base; experience; feasibility testing; fitness; follow up assessment; functional independence; hearing impairment; human old age (65+); implementation intervention; improved; innovation; instrument; mood regulation; multidisciplinary; musician; novel; preservation; programs; prototype; psychologic; response; secondary outcome; skills; sound; usability

PROJECT SUMMARY The overall objective of the proposed work is to test the benefits of a music-based intervention on speech-in- competition abilities in an older adult population that includes individuals that may be at risk of Alzheimer's disease and related dementias (ADRD). Age-related hearing difficulties are prevalent, with speech-in- competition difficulties being a common challenge amongst older adults. Critically, these difficulties and frustrations often lead to social isolation and decreased cognitive engagement, and they are associated with an increased risk of developing ADRD. There is evidence suggesting that musical training is associated with cognitive advantages in older adults, including preserved ability for speech-in-competition. However, to date, there is extremely limited knowledge and lack of experimental evidence explaining how music might benefit speech-in-competition abilities, along with more basic auditory processes and/or cognitive functions. We aim to contribute to uncovering the underlying mechanisms driving the potential effects of music and attention through an innovative, attention-based music listening intervention that cultivates auditory and attentional skills akin to those developed during formal instrumental training. To disentangle potential effects of music and attention and to get at the underlying mechanisms of music effects, we will compare outcomes of this attention-based music intervention with those of two active control interventions that consist of either passive music listening or active listening to non-music sounds. Specific aims are to develop and test the feasibility of music and control interventions and assessments targeting auditory processing and cognition (R61; Aim 1); test for intervention- specific improvements in speech-in-competition using a randomized-controlled trial (R33; Aim 2); and determine whether experimental and control interventions differentially impact measures of auditory processing, memory, and attention, and test how these may mediate performance on measures of speech-in-competition (R33; Aim 3). Long-term objectives are to understand the key mechanisms underlying the benefits of music with the overall goal to inform interventions aimed at mitigating the effects of ADRD. This proposal is transformative in that it utilizes an innovative approach to uncover potential benefits and underlying mechanisms of music by testing the added benefits of interventions and testing their benefits against a broad set of outcomes measures that can be used to further understand the malleability of auditory processes and cognition in aging. In addition, the intervention is cost-effective, easily administrable, and accessible to individuals who may not possess the physical capabilities or resources that formal instrumental practice demands. In addition, music has been shown to provide other benefits including mood regulation and psychological well-being, and as such, the intervention may have benefits that go beyond the auditory or cognitive domain. Overall, the proposed work aims to contribute to the amelioration and/or prevention of cognitive decline in individuals that may be at risk for developing ADRD.

项目摘要 拟议工作的总体目标是测试基于音乐的干预对语音的益处， 老年人群体（包括可能有阿尔茨海默病风险的人）的竞争能力 疾病及相关痴呆（ADRD）。与年龄相关的听力困难很普遍，其中言语障碍 竞争困难是老年人面临的共同挑战。这些困难和 挫折感通常会导致社交孤立和认知参与度下降，它们与 发展ADRD的风险增加。有证据表明音乐训练与 老年人的认知优势，包括在比赛中保留的演讲能力。然而，迄今为止， 关于音乐如何有益于人类健康的知识极其有限， 沿着更基本的听觉过程和/或认知功能。我们的目标是 有助于揭示驱动音乐和注意力潜在影响的潜在机制， 一种创新的，基于注意力的音乐听力干预，培养听觉和注意力技能， 在正式的乐器训练中发展出来的。为了解开音乐和注意力的潜在影响， 为了了解音乐效果的潜在机制，我们将比较这种基于注意力的音乐的结果。 干预与两种主动控制干预的干预，包括被动听音乐或主动 听非音乐的声音。具体目标是开发和测试音乐和控制的可行性 针对听觉处理和认知的干预和评估（R61;目标1）;干预测试- 使用随机对照试验（R33; Aim 2）对比赛中的演讲进行具体改善;并确定 实验和对照干预是否对听觉处理，记忆， 和注意力，并测试这些如何可能调解的措施，在竞争中的讲话表现（R33;目标 3）。长期目标是了解音乐益处的关键机制， 目标是为旨在减轻ADRD影响的干预措施提供信息。这一提议具有变革性，因为它 利用创新的方法，通过测试音乐的潜在好处和潜在机制， 增加干预措施的好处，并根据一套广泛的成果衡量标准测试其好处， 用于进一步了解衰老过程中听觉过程和认知的可塑性。此外该 干预具有成本效益，易于管理，并且可能不具备 正式工具练习所需要的身体能力或资源。此外，音乐也被证明 提供其他益处，包括情绪调节和心理健康，因此，干预 可能有超越听觉或认知领域的益处。总体而言，拟议工作旨在促进 改善和/或预防可能处于发展ADRD风险中的个体的认知下降。