Chronic Postsurgical Pain Across the Lifespan: Brain State and Treatment
贯穿一生的慢性术后疼痛:大脑状态和治疗
基本信息
- 批准号:10274659
- 负责人:
- 金额:$ 44.25万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-09-01 至 2026-06-30
- 项目状态:未结题
- 来源:
- 关键词:AddressAdolescenceAdolescentAdultAffectAnimal ModelBehavior TherapyBehavioralBrainChronicClinicClinicalClinical TrialsCollaborationsDiagnosisEvolutionFundingGoalsGrantIndividualInterventionLaboratoriesLiteratureLongevityMeasuresMentored Patient-Oriented Research Career Development AwardModelingNeurobiologyNeurologicNeurosciencesOperative Surgical ProceduresPainPatientsPersistent painPhysical FunctionPostoperative PainPreventionProcessProspective StudiesPsychophysicsPublic HealthPublishingQuality of lifeResearchResearch DesignRisk FactorsSeveritiesSignal TransductionSynaptic plasticityTranslational ResearchVisionWorkage relatedbehavioral pharmacologybiopsychosocialeffective therapyemotional functioningevidence baseneuroimagingopioid epidemicpatient orientedpre-clinicalprescription opioidprogramspsychologicresiliencesurgical painsurgical risktranslational approachtreatment as usualtreatment responsetreatment strategy
项目摘要
Project Summary
Statement of the Problem:
Chronic post-surgical pain (CPSP), defined as pain lasting longer than two-months after surgery, is a significant
public health problem affecting up to 80% of patients presenting for surgery. There are far-reaching
consequences for quality of life and physical and emotional functioning for those affected by CPSP and
complicating this crisis is the number of opioids prescribed after surgery with over 80% of patients receiving
opioid prescriptions after low-risk surgery. Integrative research and effective treatment strategies are lacking.
Overview of Research in the Laboratory:
My grant funded research, including my current K23 Award, has focused on identifying biopsychosocial
predictors of CPSP through the use of pre-clinical and clinical models and assuming a life-span perspective for
identifying predictors and prevention of CPSP. In 2013, I published the largest prospective study to date
identifying long-term pain trajectories and predictors of CPSP in young people and in 2018 results of Aim 1 of
my K23 Award, utilizing an animal model of CPSP, received Editor’s Choice. My approach is to integrate clinical,
psychological, and brain measures in order to understand the neurobiological processes that contribute to the
evolution or resilience of CPSP.
Goals for the Next 5 Years:
In the next 5 years, I will continue to utilize a translational approach to examine risk factors for CPSP and extend
upon my K23 work to: 1) utilize psychophysics and neuroimaging to understand the effects of CPSP on synaptic
plasticity from adolescence into adulthood and 2)
evaluate the effects of an evidence-based behavioral pain
intervention, compared to Treatment as Usual, on the fNIRS signal in groups of adolescent and adult patients
diagnosed with CPSP in order to compare Responders (improvement in pain severity, interference, &
functioning) vs. Non-Responders.
The projects outlined in the MIRA will be accomplished by my continued
collaborations with colleagues who have expertise in surgery, pain psychophysics, neuroscience, and
neuroimaging.
Overall Vision of the Research Program:
The goals of the R35 will be to: 1) enhance our understanding of the neurobiology of CPSP; 2) provide a metric
to follow patients with CPSP in the clinic; 3) provide a metric for those who will chronify; 4) understand the age-
related differences in CPSP; and 5) define an initial paradigm that may enhance our capability for developing
individually tailored patient-oriented interventions at both a behavioral and pharmacological level.
项目摘要
问题陈述:
慢性术后疼痛(CPSP),定义为术后持续时间超过两个月的疼痛,是一个显著的
公共卫生问题影响到高达80%的手术患者。有深远的
对受CPSP影响的人的生活质量以及身体和情感功能的影响,
使这一危机复杂化的是手术后处方的阿片类药物的数量,超过80%的患者接受
低风险手术后的阿片类药物处方缺乏综合研究和有效的治疗策略。
实验室研究概况:
我的基金资助的研究,包括我目前的K23奖,重点是确定生物心理社会
通过使用临床前和临床模型,并假设寿命的角度来看,
确定CPSP的预测因素和预防。2013年,我发表了迄今为止规模最大的前瞻性研究
确定年轻人的长期疼痛轨迹和CPSP的预测因素,以及2018年目标1的结果,
我的K23奖,利用CPSP的动物模型,获得了编辑的选择。我的方法是整合临床,
心理和大脑的措施,以了解神经生物学过程,有助于
CPSP的发展或恢复力。
未来五年的目标:
在接下来的5年里,我将继续利用转化的方法来检查CPSP的风险因素,
在我的K23工作中:1)利用心理物理学和神经影像学来了解CPSP对突触的影响,
从青少年到成年的可塑性; 2)
评估循证行为疼痛的影响,
干预,与治疗作为药物相比,对青少年和成人患者组的fNIRS信号的影响
诊断为CPSP,以比较应答者(疼痛严重程度的改善,干扰,
功能)与无应答者。
MIRA中概述的项目将由我继续完成
与在外科、疼痛心理物理学、神经科学和
神经成像
研究计划的总体愿景:
R35的目标是:1)加强我们对CPSP神经生物学的理解; 2)提供一个衡量标准,
在诊所随访CPSP患者; 3)为那些将慢性化的患者提供一个指标; 4)了解年龄-
CPSP中的相关差异;以及5)定义可以增强我们开发能力的初始范式
在行为和药理学水平上进行个性化定制的以患者为导向的干预。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Christine Barrett Sieberg其他文献
Christine Barrett Sieberg的其他文献
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{{ truncateString('Christine Barrett Sieberg', 18)}}的其他基金
Chronic Postsurgical Pain Across the Lifespan: Brain State and Treatment
贯穿一生的慢性术后疼痛:大脑状态和治疗
- 批准号:
10645142 - 财政年份:2021
- 资助金额:
$ 44.25万 - 项目类别:
Chronic Postsurgical Pain Across the Lifespan: Brain State and Treatment
贯穿一生的慢性术后疼痛:大脑状态和治疗
- 批准号:
10454929 - 财政年份:2021
- 资助金额:
$ 44.25万 - 项目类别:
Pediatric Persistent Post-surgical Pain: From Animals to Application
小儿术后持续疼痛:从动物到应用
- 批准号:
9341363 - 财政年份:2016
- 资助金额:
$ 44.25万 - 项目类别:
Pediatric Persistent Post-surgical Pain: From Animals to Application
小儿术后持续疼痛:从动物到应用
- 批准号:
9162043 - 财政年份:2016
- 资助金额:
$ 44.25万 - 项目类别:
Pediatric Persistent Post-surgical Pain: From Animals to Application
小儿术后持续疼痛:从动物到应用
- 批准号:
9757783 - 财政年份:2016
- 资助金额:
$ 44.25万 - 项目类别:
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