Administrative Supplement to Physical Activity, Sedentary Behavior, and Venous Thromboembolism Risk

对体力活动、久坐行为和静脉血栓栓塞风险的行政补充

• 批准号: 10273740
• 负责人: Laura Brienne Harrington
• 金额: $ 5.34万
• 依托单位: KAISER FOUNDATION RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-19 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10273740
• 关键词: Accelerometer; Administrative Supplement; Aging; Area; Biological Markers; Blood coagulation; Cardiac rehabilitation; Cardiovascular Diseases; Cardiovascular system; Clinical; Complex; Cross-Over Studies; Data; Data Collection; Deep Vein Thrombosis; Doctor of Philosophy; Elderly; Epidemiologist; Epidemiology; Evaluation; Event; Female; Fibrin fragment D; Funding; Future; Generations; Goals; Guidelines; Hemostatic Agents; Hemostatic function; Hour; Incidence; Individual; K-Series Research Career Programs; Life; Life Style; Malignant Neoplasms; Measures; Mentored Research Scientist Development Award; Mentors; Methodology; Morbidity - disease rate; National Heart, Lung, and Blood Institute; Nested Case-Control Study; Nurses' Health Study; Obesity; Outcome; Parents; Patient Self-Report; Persons; Physical activity; Population; Prognosis; Public Health; Publishing; Pulmonary Embolism; Recommendation; Reporting; Research; Research Design; Risk; Risk Factors; Scientist; Secondary Prevention; Strenuous Exercise; Survivors; Thrombin; Training; Triad Acrylic Resin; United States; United States National Institutes of Health; Venous; Woman; Women' s Health; Work; activated Protein C; adverse outcome; base; cardiovascular risk factor; career; career development; cohort; design; epidemiology study; improved; innovation; male; moderate-to-vigorous physical activity; modifiable risk; mortality; public health relevance; sedentary lifestyle; thrombotic; venous thromboembolism

Summary Venous thromboembolism (VTE) is the third most common cardiovascular disease in the United States. Venous stasis, which can occur during prolonged periods of inactivity, is a known risk factor for VTE; however, the relationship between physical activity and VTE is inconsistent and guidance regarding physical activity after a VTE is lacking. The overarching goal of this proposed “Administrative Supplement for Continuity and Retention of NIH Mentored Career Development (K) Award Recipients and Scholars” is to provide supplemental support of the scientific and training aims of the NHLBI-funded K01, “Physical Activity, Sedentary Behavior, and Venous Thromboembolism Risk”, following a life event. Dr. Laura B. Harrington's ongoing parent K01 award aims to further our understanding of physical activity and sedentary behavior in relation to: (1) incident VTE risk, (2) short-term VTE risk following physical activity, (3) long-term prognosis following an incident VTE, and (4) hemostatic factor levels, which are associated with thrombotic event risk. This study leverages existing data from the Women's Health Initiative and the Nurses' Health Studies I and II cohorts in addition to newly collecting data in the setting of a case-crossover study. Innovative aspects of the proposed work include the evaluation of accelerometer-measured physical activity and sedentary behavior in relation to VTE risk, the evaluation of VTE risk following physical activity using case-crossover methodology, the evaluation of physical activity and sedentary behavior with long-term prognosis among VTE survivors, and the evaluation of usual physical activity in relation to hemostatic parameter measures. Not only are the proposed scientific aims of

总结 静脉血栓栓塞（VTE）是美国第三大常见的心血管疾病。 静脉淤滞，可能发生在长期不活动期间，是VTE的已知风险因素;然而， 体力活动和VTE之间的关系是不一致的， 缺乏职业教育。这一拟议的“连续性和 保留NIH指导职业发展（K）奖获得者和学者”是为了提供 补充支持NHLBI资助的K 01“体育活动，久坐不动”的科学和培训目标 行为和静脉血栓栓塞风险”。劳拉B医生。哈灵顿的现任家长 K 01奖旨在进一步了解身体活动和久坐行为与以下方面的关系：（1） 偶发性VTE风险，（2）体力活动后的短期VTE风险，（3） 偶发性VTE和（4）止血因子水平，与血栓形成事件风险相关。本研究 利用妇女健康倡议和护士健康研究I和II队列的现有数据， 除了在病例交叉研究中新收集的数据外。拟议战略的创新方面 工作包括评估加速度计测量的身体活动和久坐不动的行为， VTE风险，使用病例交叉方法评价体力活动后的VTE风险， 评估VTE幸存者的体力活动和久坐行为与长期预后， 评价与止血参数测量相关的日常体力活动。不仅提议 科学目的