Physical Activity, Sedentary Behavior, and Venous Thromboembolism Risk

摘要： 静脉血栓栓塞（VTE）是美国第三大常见的心血管疾病。 静脉淤滞，可能发生在长期不活动期间，是VTE的已知风险因素;然而， 体力活动和VTE之间的关系是不一致的， 缺乏职业教育。拟议科学目标的首要目标是进一步了解 体力活动和久坐行为与以下方面的关系：（1）偶发性VTE风险，（2）短期VTE 体力活动后的风险，（3）VTE事件后的长期预后，以及（4）止血因素 水平，这与血栓形成事件的风险。这项研究将利用现有的数据， 妇女健康倡议和护士健康研究I和II队列，除了新收集的数据， 病例交叉研究的背景。拟议工作的创新方面包括： 加速度计测量的身体活动和久坐行为与VTE风险的关系， 使用病例交叉方法，评估体力活动后的风险， VTE幸存者久坐行为与长期预后的关系，以及日常体格检查的评价 与止血参数测量相关的活性。不仅提出的科学目标，

Abstract: Venous thromboembolism (VTE) is the third most common cardiovascular disease in the United States. Venous stasis, which can occur during prolonged periods of inactivity, is a known risk factor for VTE; however, the relationship between physical activity and VTE is inconsistent and guidance regarding physical activity after a VTE is lacking. The overarching goal of the proposed scientific aims is to further our understanding of the associations of physical activity and sedentary behavior in relation to: (1) incident VTE risk, (2) short-term VTE risk following physical activity, (3) long-term prognosis following an incident VTE, and (4) hemostatic factor levels, which are associated with thrombotic event risk. This study will leverage existing data from the robust Women’s Health Initiative and the Nurses’ Health Studies I and II cohorts in addition to newly collecting data in the setting of a case-crossover study. Innovative aspects of the proposed work include the evaluation of accelerometer-measured physical activity and sedentary behavior in relation to VTE risk, the evaluation of VTE risk following physical activity using case-crossover methodology, the evaluation of physical activity and sedentary behavior with long-term prognosis among VTE survivors, and the evaluation of usual physical activity in relation to hemostatic parameter measures. Not only are the proposed scientific aims of