Physical Activity, Sedentary Behavior, and Venous Thromboembolism Risk

摘要： 静脉血栓栓塞症(VTE)是美国第三常见的心血管疾病。 静脉停滞可在长时间不活动期间发生，是VTE的已知危险因素；然而， 体力活动与VTE的关系不一致，体力活动后的指导 缺少一支VTE。提出的科学目标的首要目标是加深我们对 体力活动和久坐行为与：(1)发生VTE的风险，(2)短期VTE的关系 体力活动后的风险，(3)发生VTE后的长期预后，以及(4)止血因素 水平，这与血栓事件风险有关。这项研究将利用来自Robust 妇女健康倡议和护士健康研究I和II队列，以及#年新收集的数据 病例交叉研究的背景。拟议工作的创新方面包括评价 加速计-测量的体力活动和久坐行为与VTE风险的关系，VTE的评估 使用病例-交叉方法的体力活动后的风险、体力活动的评估和 静坐行为与VTE存活者长期预后的关系以及对常规体格检查的评估 与止血参数措施相关的活动。提出的科学目标不仅是

Abstract: Venous thromboembolism (VTE) is the third most common cardiovascular disease in the United States. Venous stasis, which can occur during prolonged periods of inactivity, is a known risk factor for VTE; however, the relationship between physical activity and VTE is inconsistent and guidance regarding physical activity after a VTE is lacking. The overarching goal of the proposed scientific aims is to further our understanding of the associations of physical activity and sedentary behavior in relation to: (1) incident VTE risk, (2) short-term VTE risk following physical activity, (3) long-term prognosis following an incident VTE, and (4) hemostatic factor levels, which are associated with thrombotic event risk. This study will leverage existing data from the robust Women’s Health Initiative and the Nurses’ Health Studies I and II cohorts in addition to newly collecting data in the setting of a case-crossover study. Innovative aspects of the proposed work include the evaluation of accelerometer-measured physical activity and sedentary behavior in relation to VTE risk, the evaluation of VTE risk following physical activity using case-crossover methodology, the evaluation of physical activity and sedentary behavior with long-term prognosis among VTE survivors, and the evaluation of usual physical activity in relation to hemostatic parameter measures. Not only are the proposed scientific aims of