检测 TBI 后突触连接的破坏和恢复-猫眼课题宝

检测 TBI 后突触连接的破坏和恢复

批准号：

10261488

负责人：

MARK P BURNS

金额：

$41.94万

依托单位：

GEORGETOWN UNIVERSITY

依托单位国家：

美国

项目类别：

财政年份：

2018

资助国家：

美国

项目状态：

已结题

起止时间：

2018-04-15 至 2023-08-31

来源：

https://reporter.nih.gov/project-details/10261488

关键词：

Acute Adult Aging Animal Model Animals Architecture Area Award Behavior Behavioral Biochemistry Biology Brain Contusions Burn injury Chronic Clinical Data Analyses Data Collection District of Columbia Electrophysiology (science)Ensure Event Functional Magnetic Resonance Imaging Functional disorder Goals Guidelines HIV Seropositivity Heterogeneity Hippocampus (Brain)IACUC Image Impaired cognition Impairment Individual Differences Inflammation Injury Intervention Learning Long-Term Potentiation Magnetic Resonance Imaging Measures Memory Methods Modeling Molecular Biology Morphology Mus Neuronal Dysfunction Neurons Outcome Patients Pattern Phase Procedures Protocols documentation Recovery Regression Analysis Reporting Research Research Design Research Personnel Severities Statistical Data Interpretation Synapses Techniques Technology TimeLine Traumatic Brain Injury Traumatic Brain Injury recovery Validation Work animal tissue axon injury base behavioral outcome blind cognitive ability cognitive function controlled cortical impact data sharing fluid percussion injury functional MRI scan head impact improved mild traumatic brain injury multidisciplinary neural network neurobehavior neuroinflammation neuron loss neuronal circuitry novel outcome prediction preference receptor response synaptic function tau aggregation tau-1

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PROJECT SUMMARY The rationale for this proposal is that synaptic integrity is essential for neuronal function. Disruptions to synaptic integrity are downstream of common TBI pathophysiological events including neuronal cell death, axonal injury, p-tau aggregation, and neuroinflammation. The ability to detect discrete changes in synaptic integrity – regardless of the upstream mechanism of synapse loss – will allow clinicians to track the ability of clinical interventions to improve chronic outcome in patients. The objective of this proposal is to use measures of synaptic integrity to predict chronic behavioral outcomes, and to validate Hcorr as a non-invasive marker of synaptic integrity for use in TBI.

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