Detecting the disruption and recovery of synaptic connectivity after TBI

检测 TBI 后突触连接的破坏和恢复

• 批准号: 10261488
• 负责人: MARK P BURNS
• 金额: $ 41.94万
• 依托单位: GEORGETOWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-04-15 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10261488
• 关键词: Acute; Adult; Aging; Animal Model; Animals; Architecture; Area; Award; Behavior; Behavioral; Biochemistry; Biology; Brain Contusions; Burn injury; Chronic; Clinical; Data Analyses; Data Collection; District of Columbia; Electrophysiology (science); Ensure; Event; Functional Magnetic Resonance Imaging; Functional disorder; Goals; Guidelines; HIV Seropositivity; Heterogeneity; Hippocampus (Brain); IACUC; Image; Impaired cognition; Impairment; Individual Differences; Inflammation; Injury; Intervention; Learning; Long-Term Potentiation; Magnetic Resonance Imaging; Measures; Memory; Methods; Modeling; Molecular Biology; Morphology; Mus; Neuronal Dysfunction; Neurons; Outcome; Patients; Pattern; Phase; Procedures; Protocols documentation; Recovery; Regression Analysis; Reporting; Research; Research Design; Research Personnel; Severities; Statistical Data Interpretation; Synapses; Techniques; Technology; TimeLine; Traumatic Brain Injury; Traumatic Brain Injury recovery; Validation; Work; animal tissue; axon injury; base; behavioral outcome; blind; cognitive ability; cognitive function; controlled cortical impact; data sharing; fluid percussion injury; functional MRI scan; head impact; improved; mild traumatic brain injury; multidisciplinary; neural network; neurobehavior; neuroinflammation; neuron loss; neuronal circuitry; novel; outcome prediction; preference; receptor; response; synaptic function; tau aggregation; tau-1

PROJECT SUMMARY The rationale for this proposal is that synaptic integrity is essential for neuronal function. Disruptions to synaptic integrity are downstream of common TBI pathophysiological events including neuronal cell death, axonal injury, p-tau aggregation, and neuroinflammation. The ability to detect discrete changes in synaptic integrity – regardless of the upstream mechanism of synapse loss – will allow clinicians to track the ability of clinical interventions to improve chronic outcome in patients. The objective of this proposal is to use measures of synaptic integrity to predict chronic behavioral outcomes, and to validate Hcorr as a non-invasive marker of synaptic integrity for use in TBI.

项目总结