Center for Molecular Imaging Technology and Translation (CMITT)

分子成像技术与翻译中心 (CMITT)

• 批准号: 10263161
• 负责人: Georges El Fakhri
• 金额: $ 119.02万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-30 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10263161
• 关键词: Affect; Animals; Asia; Australia; Award; Biochemical; Biochemical Reaction; Biomedical Technology; Brain; Breathing; Cardiac; Communities; Complex; Country; Data; Development; Direct Costs; Discipline; Disease; Drug Kinetics; Endowment; Engineering; Ensure; Environment; Europe; Evolution; Faculty; Functional Magnetic Resonance Imaging; Gamma Rays; General Hospitals; Goals; Growth; Heart; Hospitals; Image; Imaging technology; Institution; Joint repair; Joints; Knowledge; Magnetic Resonance Imaging; Malignant Neoplasms; Malignant neoplasm of brain; Manufacturer Name; Maps; Massachusetts; Measurement; Measures; Medical Imaging; Medical center; Methodology; Methods; Modality; Modeling; Molecular; Molecular Probes; Motion; National Institute of Biomedical Imaging and Bioengineering; Normal tissue morphology; Organ; Pathway interactions; Patients; Pharmacology; Physicians; Physiological; Physiological Processes; Physiology; Positron-Emission Tomography; Postdoctoral Fellow; Property; Radiochemistry; Radiology Specialty; Research; Resolution; Resources; Sampling; Science; Scientist; Services; Signal Transduction; Site; Skeletal Muscle; Statistical Models; Students; System; Technology; Translations; Vision; Visualization; accurate diagnosis; attenuation; bioimaging; cerebral blood volume; chemical reaction; collaborative environment; data acquisition; design; follow-up; human subject; image processing; image reconstruction; imaging agent; imaging facilities; imaging modality; imaging scientist; improved; instrument; kinetic model; molecular imaging; multimodality; neurotransmission; novel; novel strategies; pharmacokinetic model; reconstruction; soft tissue; spatiotemporal; technology development; technology research and development; temporal measurement; tomography; training opportunity

Project Summary / Abstract for the Center for Molecular Imaging Technology and Translation The Center for Molecular Imaging Technology and Translation (CMITT) will be a national resource located within the newly created Gordon Center for Medical Imaging (GCMI) at the Massachusetts General Hospital. Working within the interdisciplinary environment (e.g., imaging sciences; image reconstruction and processing; pharmacokinetics) of the Gordon Center, the aim of CMITT is to develop, validate and disseminate cutting-edge imaging technologies that take advantage of the game-changing capabilities afforded by simultaneous acquisition of PET and MR. CMITT consists of three Technology Research and Development projects (TR&Ds): TR&D1 aims at breaking down the resolution barrier in PET. By developing enabling technologies for attenuation and motion field estimation as well as PSH modeling we can achieve the intrinsic resolution of PET, about 4mm, in the breathing patient by using novel accelerated MR acquisitions with sparse sampling. TR&D2 will develop the unified statistical model of joint reconstruction of PET and MR that incorporates the corrections developed in TR&D1. TR&D3 will develop the pharmacokinetic modeling of physiological processes in simultaneous PET/MR (TR&D3) in quantitative PET/MR images that enable exploration of molecular physiology. There is currently no PET-focused Biomedical Technology Resource Center supported by NIBIB. Thus CMITT seeks to fill a clear national need for PET/MR imaging technology development, one that is agnostic with respect to commercial platform and, in many instances, applies equally to PET or MR alone. The Resource provides a unique environment with an interdisciplinary team of highly accomplished scientists, engineers, and clinicians with diverse expertise in multiple modalities and disciplines that supports service use of the Center's facilities by imaging scientists throughout the country as well as Europe, Asia and Australia. CMITT will provide extensive training opportunities for students, post-doctoral fellows, and faculty, and seeks to advance the field of molecular imaging of normal function and disease through active dissemination of new knowledge and technology.

分子成像技术与翻译中心项目摘要/摘要 分子成像技术和翻译中心(CMITT)将是一个位于 在马萨诸塞州总医院新成立的戈登医学成像中心(GCMI)内。 在跨学科环境中工作(例如，成像科学；图像重建和处理； 药代动力学)，CMITT的目标是开发、验证和传播尖端技术 成像技术，利用同时收购 PET和CMITT先生由三个技术研究和开发项目(tr&d)组成：tr&d1旨在 打破了PET中的分辨率障碍。通过开发支持衰减和运动场的技术 估计以及PSH模型，我们可以达到PET的固有分辨率，约4 mm，在呼吸 患者通过使用稀疏采样的新型加速磁共振采集。TR&D2将发展统一统计 PET和MR联合重建模型，包含了在tr&d1中开发的校正。Tr&d3将 定量建立PET/MR同步给药生理过程的药代动力学模型 能够探索分子生理学的PET/MR图像。 目前还没有由NIBIB支持的专注于PET的生物医学技术资源中心。因此，CMITT 寻求满足国家对PET/MR成像技术开发的明确需求，这一需求与 商业平台，在许多情况下，同样适用于PET或MR。该资源提供了独特的 拥有一支由具有丰富经验的科学家、工程师和临床医生组成的跨学科团队的环境 具备多种模式和学科的专业知识，通过成像支持中心设施的服务使用 科学家遍布全国以及欧洲、亚洲和澳大利亚。CMITT将提供广泛的培训 为学生、博士后研究员和教职员工提供机会，并寻求推动分子成像领域的发展 通过积极传播新知识和新技术来实现正常功能和疾病。