PET/MR Mapping of Myocardial Membrane Potential

心肌膜电位 PET/MR 绘图

• 批准号: 9392425
• 负责人: Georges El Fakhri
• 金额: $ 82.03万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9392425
• 关键词: Ablation; Age; Animals; Area; Arrhythmia; Binding; Biological Markers; Cardiac; Cardiomyopathies; Chronic; Cicatrix; Clinical; Data; Detection; Development; Disease; Drug Monitoring; Elements; Evaluation; Extracellular Space; Family suidae; Gadolinium; Gold; Heart; Human; Hypertrophy; Image; Infarction; Injury; Ischemia; Kinetics; Left; Lesion; Magnetic Resonance Imaging; Maps; Mathematics; Measurement; Measures; Membrane Potentials; Methodology; Methods; Mitochondria; Mitochondrial Diseases; Modeling; Morbidity - disease rate; Motion; Myocardial; Myocardial Infarction; Myocardium; Myopathy; Nature; Patients; Performance; Pharmacotherapy; Plasma; Positron-Emission Tomography; Procedures; Rattus; Recurrence; Research; Risk; Scanning; Schedule; Sensitivity and Specificity; Site; Skeletal Muscle; Sudden Death; Surface; System; Techniques; Testing; Three-Dimensional Imaging; Tissue Viability; Tissues; Tracer; Validation; Variant; Ventricular; Ventricular Arrhythmia; Ventricular Tachycardia; Work; attenuation; base; clinical practice; clinical translation; cohort; cost; extracellular; heart motion; human subject; improved; in vivo; injured; insight; interest; man; mitochondrial membrane; reconstruction; respiratory

The current state-of-the-art technique for ventricular tachycardia (VT) ablation utilizes electroanatomic mapping (EAM) and site-specific electrograms to guide delivery of ablation lesions. Although EAM can assist in distinguishing viable tissue from scar in infarcted areas, it does not represent a true gold standard for differentiating scar from viable or healthy myocardium. The limitations of EAM are reflected in the frequent recurrences (~30%) of VT after ablation. The basic insight of this proposal is that 3D imaging of mitochondrial membrane potential (MP) and the size of the extracellular space (ECS) provides a more comprehensive assessment of the arrhythmogenic substrate than EAM. We propose PET/MRI to map both mitochondrial MP and ECS for use in the detection of left ventricular (LV) scar. Our approach provides a full 3D map of myocardial membrane potential, in contrast to the 1-2mm depth beneath the endo- and epicardial surfaces afforded by EAM. The method is noninvasive and well suited to clinical translation for study of a variety of diseases, including ventricular arrhythmias, cardiomyopathy, hypertrophy, skeletal muscle disorders, etc.

当前最先进的室性心动过速 (VT) 消融技术采用 电解剖图 (EAM) 和特定部位电图来指导消融 病变。虽然 EAM 可以帮助区分梗塞区域的存活组织和疤痕， 它并不代表区分疤痕与存活或健康的真正黄金标准 心肌。 EAM 的局限性反映在 VT 频繁复发 (~30%) 消融后。该提案的基本见解是线粒体的 3D 成像 膜电位 (MP) 和细胞外空间 (ECS) 的大小提供了更多信息 综合评估致心律失常底物优于EAM。我们建议 PET/MRI 可绘制线粒体 MP 和 ECS，用于检测左心室 （LV）疤痕。我们的方法提供了心肌膜电位的完整 3D 图， 与 EAM 提供的心内膜和心外膜表面下方 1-2mm 的深度形成对比。 该方法是非侵入性的，非常适合临床转化以研究各种疾病 疾病，包括室性心律失常、心肌病、肥大、骨骼肌 障碍等