Washington University Clinical Research Site for the Network of Excellence in Neuroscience Clinical Trials (NeuroNEXT)- RFA-NS-17-024

华盛顿大学神经科学临床试验卓越网络 (NeuroNEXT) 临床研究网站 - RFA-NS-17-024

• 批准号: 10593625
• 负责人: DAVID B CLIFFORD
• 金额: $ 27.8万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10593625
• 关键词: Address; Adult; Affect; Agreement; Biological Markers; Childhood; Clinical; Clinical Research; Clinical Trials; Clinical Trials Design; Clinical Trials Network; Data; Development; Fostering; Funding; Future; Goals; Grant; Health; Human; Human Resources; Infrastructure; Institution; Institutional Review Boards; Investigation; Leadership; Link; Maintenance; Mentors; Mission; Monitor; Multi-Institutional Clinical Trial; National Institute of Neurological Disorders and Stroke; Neurologic; Neurologist; Neurology; Neurosciences; Neurosurgeon; Patients; Performance; Phase; Phase II Clinical Trials; Protocols documentation; Psychiatrist; Reaction Time; Records; Research; Research Design; Research Personnel; Research Support; Resources; Site; Specialist; Speech Therapist; Speed; Time; Training; Training Support; Translations; Universities; Washington; Work; career development; clinical practice; clinical research site; clinical translation; data submission; design; experience; improved; nervous system disorder; neuroimaging; neurological rehabilitation; phase 2 study; prevent; programs; recruit; success; support network; training opportunity

This project will continue the Washington University NeuroNEXT site contributing to the Network of Excellence in Neuroscience Clinical Trials (NeuroNEXT sites) program. The overall goal of the program will contribute to the success in identifying and completing Phase 2 clinical trials that will speed translation of concepts to clinical practice for neurological conditions. The project will enhance the infrastructure for neuroscience related clinical trials at Washington University in St Louis (WUSTL) through supporting critical leadership personnel, support for the Neurological Clinical Research Unit (NCRU) and administrative infrastructure for multicenter clinical trials performance at WUSTL. The grant will provide key leadership assuring the efficient conduct of NeuroNEXT network clinical trials at WUSTL by funding a site PI and coordinator committed to assuring timely and accurate assessment of proposed concepts, organization and support of site protocol teams, and quality oversight for NeuroNEXT trials. The project also supports training for emerging investigators for participation in neurological clinical research through a program to support an outstanding younger investigator financially and through mentoring and formal training in theoretical and practical clinical trial practices, thus enriching the pool of investigators available for future investigations.

该项目将继续华盛顿大学NeuroNEXT网站，为神经科学临床试验卓越网络（NeuroNEXT网站）计划做出贡献。该计划的总体目标将有助于成功确定和完成2期临床试验，这将加速将概念转化为神经系统疾病的临床实践。该项目将通过支持关键领导人员、支持神经学临床研究单位（NCRU）和WUSTL多中心临床试验绩效的管理基础设施，加强华盛顿大学圣刘易斯（WUSTL）神经科学相关临床试验的基础设施。该补助金将提供关键的领导，确保在WUSTL有效地进行NeuroNEXT网络临床试验，资助一个网站PI和协调员，致力于确保及时准确地评估拟议的概念，组织和支持网站协议团队，并对NeuroNEXT试验进行质量监督。该项目还通过一项计划支持新兴研究者参与神经学临床研究，以资助优秀的年轻研究者，并通过理论和实际临床试验实践的指导和正式培训，从而丰富了未来研究的研究者队伍。

项目成果

Nemesis of neglected neurosarcoidosis.

被忽视的神经结节病的克星。

• DOI: 10.1002/acn3.247
• 发表时间: 2015
• 期刊: Annals of clinical and translational neurology
• 影响因子: 5.3
• 作者: Clifford,DavidB

A Programme for Risk Assessment and Minimisation of Progressive Multifocal Leukoencephalopathy Developed for Vedolizumab Clinical Trials.

为维多珠单抗临床试验开发的风险评估和最小化进行性多灶性白质脑病的计划。

• DOI: 10.1007/s40264-018-0669-8
• 发表时间: 2018
• 期刊: Drug safety
• 影响因子: 4.2
• 作者: Parikh,Asit;Stephens,Kristin;Major,Eugene;Fox,Irving;Milch,Catherine;Sankoh,Serap;Lev,MichaelH;Provenzale,JamesM;Shick,Jesse;Patti,Mark;McAuliffe,Megan;Berger,JosephR;Clifford,DavidB
• 通讯作者: Clifford,DavidB

Tumefactive demyelination in a patient with human immunodeficiency virus.

• DOI: 10.1007/s13365-013-0165-y
• 发表时间: 2013-06
• 期刊: JOURNAL OF NEUROVIROLOGY
• 影响因子: 3.2
• 作者: Solomon, Isaac H.;Perrin, Richard J.;Clifford, David B.;Ances, Beau M.
• 通讯作者: Ances, Beau M.