Washington University Network of Excellence in Neuroscience Clinical Trials Site

描述(由申请人提供)：为响应RFA-NS-11-008，我们建议在圣路易斯的华盛顿大学(WUSTL)建立一个临床试验站点，作为由美国国家神经疾病和中风研究所(NINDS)提出的“神经科学临床试验卓越网络”(NEXT)计划的一部分。在WUSTL网站的David B Clifford医学博士(PI/PD)的领导下，WUSTL拥有由儿科和成人神经病学大多数学科的专家领导的大型神经疾病临床和研究项目，并拥有完善的研究基础设施，包括我们的神经病学临床研究部(NCRU)和临床试验经验，我们将为下一批人员提供高效的贡献者。这项建议的具体目标是：1.为临床试验网站建立领导力，优化圣路易斯华盛顿大学的能力，成为神经科学临床试验卓越网络(NEXT)的有效贡献部分2.建立与临床协调中心(CCC)、数据协调中心(DCC)和圣路易斯华盛顿大学潜在合作研究人员的合作计划，以提高整个网络的生产率，特别是WUSTL对它的贡献3.制定计划，促进招募和外联，支持开展下一步试验，其中可能包括对罕见神经疾病的研究4.制定计划，利用和支持当地临床研究资源，特别是华盛顿大学NIH资助的临床和翻译科学研究所(ICTS)和神经临床研究单位(NCRU)5.建立手段，优化在我们网站进行的临床研究的效率6.制定绩效监测计划，以提高WUSTL NEXT网站的生产率7.制定计划，促进招募和培训新的专业人员，为WUSTL和全国的翻译神经科学计划做出贡献

DESCRIPTION (provided by applicant): In response to RFA-NS-11-008 we propose to establish a clinical trial site at Washington University in St. Louis (WUSTL) as a part of the "Network of Excellence in Neuroscience Clinical Trials" (NEXT) program proposed by the National Institute of Neurological Diseases and Stroke (NINDS). Under the leadership of David B Clifford, MD (PI/PD) for the WUSTL site, with the large clinical and research programs at WUSTL in neurological disorders led by experts in most disciplines of pediatric and adult neurology, and with well -developed research infrastructure including our Neurologic Clinical Research Unit (NCRU) and experience in clinical trials we will provide a highly productive and efficient contributor to the NEXT group. Specific aims for this proposal are to: 1. Establish leadership for a Clinical Trials Site optimizing the ability of Washington University in St. Louis o be an effective contributing part of the Network for Excellence in Neuroscience Clinical Trials (NEXT) 2. Establish a plan for collaboration with the Clinical Coordinating Center (CCC), the Data Coordinating Center (DCC), and the potential co-investigators from Washington University in St. Louis to enhance productivity of the entire network, and specifically the WUSTL contributions to it 3. Establish a plan to facilitate recruitment and outreach supporting the conduct of NEXT trials that may include studies of uncommon neurological conditions 4. Establish a plan to leverage and support local clinical research resources particularly focusing on the NIH funded Institute of Clinical and Translational Sciences (ICTS) at Washington University and the Neuroclinical Research Unit (NCRU) 5. Establish means to optimize the efficiency of clinical research carried out at our site 6. Establish plan for performance monitorin to enhance the productivity of the WUSTL NEXT site 7. Establish plans to facilitate recruiting and training new professionals to contribute to the translational neuroscience programs at WUSTL and nationally