Washington University Network of Excellence in Neuroscience Clinical Trials Site

描述（由申请人提供）：作为对RFA-NS-11-008的回应，我们提议在圣路易斯华盛顿大学（WUSTL）建立一个临床试验中心，作为美国国家神经疾病和卒中研究所（NINDS）提出的“神经科学临床试验卓越网络”（NEXT）计划的一部分。在大卫B克利福德，医学博士（PI/PD）的领导下，WUSTL在神经系统疾病方面的大型临床和研究项目由儿科和成人神经学大多数学科的专家领导，并拥有完善的研究基础设施，包括我们的神经临床研究单位（NCRU）和临床试验经验，我们将为NEXT组提供一个高产高效的贡献者。这项建议的具体目标是：1.建立临床试验中心的领导地位，优化圣路易斯华盛顿大学的能力，成为神经科学临床试验卓越网络（NEXT）的有效贡献部分2。制定与临床协调中心（CCC）、数据协调中心（DCC）和圣路易斯华盛顿大学的潜在合作研究者合作的计划，以提高整个网络的生产力，特别是WUSTL对网络的贡献3。制定计划，以促进招募和推广，支持NEXT试验的开展，其中可能包括对不常见神经系统疾病的研究4。制定一项计划，以利用和支持当地的临床研究资源，特别是关注美国国立卫生研究院资助的华盛顿大学临床和转化科学研究所（ICTS）和神经临床研究单位（NCRU）5。建立优化临床研究效率的方法6.建立绩效监控计划，以提高WUSTL NEXT工厂的生产力。制定计划，促进招聘和培训新的专业人员，为WUSTL和全国的翻译神经科学项目做出贡献

DESCRIPTION (provided by applicant): In response to RFA-NS-11-008 we propose to establish a clinical trial site at Washington University in St. Louis (WUSTL) as a part of the "Network of Excellence in Neuroscience Clinical Trials" (NEXT) program proposed by the National Institute of Neurological Diseases and Stroke (NINDS). Under the leadership of David B Clifford, MD (PI/PD) for the WUSTL site, with the large clinical and research programs at WUSTL in neurological disorders led by experts in most disciplines of pediatric and adult neurology, and with well -developed research infrastructure including our Neurologic Clinical Research Unit (NCRU) and experience in clinical trials we will provide a highly productive and efficient contributor to the NEXT group. Specific aims for this proposal are to: 1. Establish leadership for a Clinical Trials Site optimizing the ability of Washington University in St. Louis o be an effective contributing part of the Network for Excellence in Neuroscience Clinical Trials (NEXT) 2. Establish a plan for collaboration with the Clinical Coordinating Center (CCC), the Data Coordinating Center (DCC), and the potential co-investigators from Washington University in St. Louis to enhance productivity of the entire network, and specifically the WUSTL contributions to it 3. Establish a plan to facilitate recruitment and outreach supporting the conduct of NEXT trials that may include studies of uncommon neurological conditions 4. Establish a plan to leverage and support local clinical research resources particularly focusing on the NIH funded Institute of Clinical and Translational Sciences (ICTS) at Washington University and the Neuroclinical Research Unit (NCRU) 5. Establish means to optimize the efficiency of clinical research carried out at our site 6. Establish plan for performance monitorin to enhance the productivity of the WUSTL NEXT site 7. Establish plans to facilitate recruiting and training new professionals to contribute to the translational neuroscience programs at WUSTL and nationally