权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Neural recruitment during self-control of smoking: An fMRI paradigm

吸烟自我控制过程中的神经募集：功能磁共振成像范式

基本信息

批准号：
7487077
负责人：
John R Monterosso
金额：
$ 35.94万
依托单位：
UNIVERSITY OF SOUTHERN CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-09-01 至 2011-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7487077
关键词：
Abstinence Addictive Behavior Anterior Area Attention Basic Science Behavior Behavioral Behavioral inhibition Biological Neural Networks Boxing Brain Brain region Breathing Characteristics Cigarette Cigarette Smoker Clinical Data Decision Making Dorsal Drug usage Effectiveness Environment Equipment and supply inventories Functional Magnetic Resonance Imaging Gambling Goals IFNG gene Image Image Analysis Impulsivity Individual Differences Inferior frontal gyrus Iowa Laboratories Magnetic Resonance Imaging Maintenance Masks Measures Methodology Methods Modeling Motor Nicotine Numbers Participant Patient Self-Report Performance Personality Pharmaceutical Preparations Prefrontal Cortex Procedures Process Property Psychometrics Recruitment Activity Reporting Research Personnel Resolution Resources Rewards Scanning Score Self-control as a personality trait Short-Term Memory Side Signal Transduction Smoke Smoking Specific qualifier value Speed Standards of Weights and Measures Substance Addiction System Task Performances Techniques Testing Therapeutic Intervention Week Work addiction base behavior measurement behavior test blood oxygen level dependent cigarette smoking cingulate cortex clinical Diagnosis clinical application craving day drug of abuse follow-up independent component analysis indexing insight neural recruitment programs relating to nervous system response smoke inhalation theories trait

项目摘要

DESCRIPTION (provided by applicant): Appetitive processes (e.g., reward-seeking and some aspects of craving) represent only one side of addiction; failed attempts to exert "self-control" over one's drug use are built-in to the clinical diagnosis of substance dependence. Attempts to study brain substrates of self-control have generally relied on laboratory models, such as decision-making tasks (e.g., the Iowa Gambling Task) and speeded tests of inhibitory control (e.g., the Go/No-Go Task) that have uncertain relevance to abstaining from drug use. We propose to identify substrates of self-control more directly using functional Magnetic Resonance Imaging (fMRI) in conjunction with a specialized apparatus that allows cigarette smoke inhalation in the scanning environment. Fifty cigarette smokers (abstinent 12 h) will complete a "Smoking Self-Control Challenge" that has been developed through successful pilot work. The task includes two types of 20-sec trials: "Smoke Unavailable" trials in which participants are signaled that a valve allowing cigarette smoke inhalation is closed, and "Smoke Available" trials, in which smoke is immediately available, but participants are encouraged to "try not to smoke on as many of these rounds as you can manage". The primary functional measure will be the difference in fMRI signal between Smoke Available trials in which the participant abstains, and trials in which smoke was not available ("Voluntary Abstinence" - "Smoke Unavailable"). Craving will be measured on every trial (by button presses) to allow for its covariation, as well as to allow assessment of its potential moderating effect on neural activity during voluntary abstinence. The fMRI task will be given during two sessions separated by approximately two weeks. Based on preliminary data, we anticipate that voluntary abstinence will be associated with increased neural activity in the right ventrolateral and dorsolateral prefrontal cortex as well as in the dorsal anterior cingulate cortex and supplementary motor area. Standard psychometric techniques will be applied to assess the reliability and short-term stability of performance and of fMRI signal change during the task. Two additional days of behavioral testing will allow performance on the task to be related to established measures of decision-making, inhibitory control, and personality. The proposed method will allow imaging studies of neural systems underlying self-control, complimenting existing imaging methods used to study craving for cigarettes and drugs of abuse. With the primary procedures already operational and in use, this 2-year project should yield valuable insights into the substrates of self-control, with both basic science and clinical implications.

描述（由申请人提供）：食欲过程（例如，寻求奖励和某些方面的渴望）只是成瘾的一个方面;对药物使用施加“自我控制”的失败尝试是药物依赖临床诊断的内在因素。研究自我控制的大脑基质的尝试通常依赖于实验室模型，例如决策任务（例如，爱荷华州赌博任务）和抑制控制的加速测试（例如，Go/No-Go任务），这些任务与戒断药物使用的相关性不确定。我们建议更直接地使用功能性磁共振成像（fMRI）结合一个专门的设备，允许在扫描环境中吸入香烟烟雾识别基板的自我控制。50名吸烟者（禁欲12小时）将完成一项“吸烟自我控制挑战”，该挑战是通过成功的试点工作开发的。该任务包括两种类型的20秒试验：“烟雾不可用”试验，其中参与者被告知允许香烟烟雾吸入的阀门关闭，以及“烟雾可用”试验，其中烟雾立即可用，但鼓励参与者“尽量不要在尽可能多的这些回合中吸烟”。主要功能测量将是参与者戒烟的吸烟可用试验与吸烟不可用试验（“自愿戒烟”-“吸烟不可用”）之间的fMRI信号差异。在每次试验中（通过按下按钮）都会测量渴望，以考虑其协变，并评估其对自愿禁欲期间神经活动的潜在调节作用。fMRI任务将在两个会议期间进行，间隔约两周。根据初步数据，我们预计，自愿禁欲将与右腹外侧和背外侧前额叶皮层以及背侧前扣带皮层和辅助运动区的神经活动增加。标准的心理测量技术将被应用于评估的可靠性和短期稳定性的性能和功能磁共振成像信号的变化在任务期间。另外两天的行为测试将允许在任务上的表现与决策，抑制控制和个性的既定措施相关。所提出的方法将允许对自我控制的神经系统进行成像研究，补充现有的用于研究对香烟和滥用药物的渴望的成像方法。随着主要程序已经运作和使用，这个为期2年的项目应该产生有价值的见解自我控制的基板，与基础科学和临床意义。