Inflammatory Mechanisms Linking Sleep Disturbances and Cognitive Deficits in Schizophrenia in Later Life
Inflammatory Mechanisms Linking Sleep Disturbances and Cognitive Deficits in Schizophrenia in Later Life
与精神分裂症晚年睡眠障碍和认知缺陷相关的炎症机制
批准号：
10597117
负责人：
Ellen Eun-Ok Lee
金额：
$20.25万
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
项目状态：
未结题
起止时间：
2019-05-07 至 2025-04-30
关键词：
AccountingAddressAdultAffectAgeAgingAntipsychotic AgentsAttentionBehaviorBioinformaticsBiologicalBody mass indexC-reactive proteinCell CountCellsChronicChronic DiseaseCognitionCognitiveCognitive deficitsComplexDataDevelopmentDietDimensionsDoseElderlyFutureGene ExpressionGene Expression ProfilingGeneral PopulationGenomicsGoalsImmuneImpaired cognitionIncidenceIndividualInflammationInflammatoryInterleukin-6InterventionInvestigationK-Series Research Career ProgramsLinkLongitudinal StudiesMATRICS Consensus Cognitive BatteryMeasuresMediatingMediatorMental DepressionMental disordersModelingNational Institute of Mental HealthPathway interactionsPatient Self-ReportPerformancePersonsPhysical activityPittsburgh Sleep Quality IndexReportingResearchRisk FactorsSample SizeSchizophreniaScientistSeveritiesSleepSleep DisordersSleep disturbancesSleeplessnessSmokingTestingTimeTrainingUnited States National Institutes of HealthVulnerable PopulationsWomanactigraphyage relatedcareerclinical translationcognitive performancecostexecutive functionfollow-upfunctional improvementgeriatric mental healthhigh riskimprovedindexinginflammatory markerlifestyle factorsmenmiddle agemodifiable riskmolecular markerpoor sleeppromoterrecruitsexskillssleep qualitytranscription factortranslational physician
中文摘要
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英文摘要
SUMMARY/ABSTRACT
The proposed K23 application will strongly support Ellen Lee, MD’s long-term career goal of becoming an independent clinical-translational physician-scientist in geriatric mental health. This project investigates inflammatory mechanisms underlying sleep and cognition in middle-aged and older adults (41-70 years old) with schizophrenia (SZ). The proposal has considerable
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DOI：
10.2196/25779
发表时间：
2021-03-22
期刊：
JMIR aging
影响因子：
4.9
作者：
[Daly JR, Depp C, Graham SA, Jeste DV, Kim HC, Lee EE, Nebeker C]
通讯作者：
Nebeker C
DOI：
10.1017/s1041610220000927
发表时间：
2020-08
期刊：
International psychogeriatrics
影响因子：
7
作者：
[Jeste DV, Graham SA, Nguyen TT, Depp CA, Lee EE, Kim HC]
通讯作者：
Kim HC
DOI：
10.1017/s1041610221002684
发表时间：
2022-07
期刊：
INTERNATIONAL PSYCHOGERIATRICS
影响因子：
7
作者：
[Thomas, Michael L., Palmer, Barton W., Lee, Ellen E., Liu, Jinyuan, Daly, Rebecca, Tu, Xin M., Jeste, Dilip V.]
通讯作者：
Jeste, Dilip V.
DOI：
10.1080/13607863.2020.1821170
发表时间：
2021-11
期刊：
Aging & mental health
影响因子：
3.4
作者：
[Jeste DV, Di Somma S, Lee EE, Nguyen TT, Scalcione M, Biaggi A, Daly R, Liu J, Tu X, Ziedonis D, Glorioso D, Antonini P, Brenner D]
通讯作者：
Brenner D
DOI：
10.1007/s40596-020-01339-1
发表时间：
2021-04
期刊：
Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry
影响因子：
--
作者：
[Jeste DV, Patel S, Lee EE, Daly R, Govind T, Parekh R, Levin S]
通讯作者：
Levin S
共 15 条
Inflammatory Mechanisms Linking Sleep Disturbances and Cognitive Deficits in Schizophrenia in Later Life
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批准号：10405005
-
项目类别：
-
资助金额：$20.04万
-
财政年份：2019
-
负责人：Ellen Eun-Ok Lee
-
依托单位：
Inflammatory Mechanisms Linking Sleep Disturbances and Cognitive Deficits in Schizophrenia in Later Life
-
批准号：9926924
-
项目类别：
-
资助金额：$20.26万
-
财政年份：2019
-
负责人：Ellen Eun-Ok Lee
-
依托单位：
Inflammatory Mechanisms Linking Sleep Disturbances and Cognitive Deficits in Schizophrenia in Later Life
-
批准号：10159125
-
项目类别：
-
资助金额：$20.13万
-
财政年份：2019
-
负责人：Ellen Eun-Ok Lee
-
依托单位：
海外基金