Inflammatory Mechanisms Linking Sleep Disturbances and Cognitive Deficits in Schizophrenia in Later Life

与精神分裂症晚年睡眠障碍和认知缺陷相关的炎症机制

• 批准号: 10597117
• 负责人: Ellen Eun-Ok Lee
• 金额: $ 20.25万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-05-07 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10597117
• 关键词: Accounting; Address; Adult; Affect; Age; Aging; Antipsychotic Agents; Attention; Behavior; Bioinformatics; Biological; Body mass index; C-reactive protein; Cell Count; Cells; Chronic; Chronic Disease; Cognition; Cognitive; Cognitive deficits; Complex; Data; Development; Diet; Dimensions; Dose; Elderly; Future; Gene Expression; Gene Expression Profiling; General Population; Genomics; Goals; Immune; Impaired cognition; Incidence; Individual; Inflammation; Inflammatory; Interleukin-6; Intervention; Investigation; K-Series Research Career Programs; Link; Longitudinal Studies; MATRICS Consensus Cognitive Battery; Measures; Mediating; Mediator; Mental Depression; Mental disorders; Modeling; National Institute of Mental Health; Pathway interactions; Patient Self-Report; Performance; Persons; Physical activity; Pittsburgh Sleep Quality Index; Reporting; Research; Risk Factors; Sample Size; Schizophrenia; Scientist; Severities; Sleep; Sleep Disorders; Sleep disturbances; Sleeplessness; Smoking; Testing; Time; Training; United States National Institutes of Health; Vulnerable Populations; Woman; actigraphy; age related; career; clinical translation; cognitive performance; cost; executive function; follow-up; functional improvement; geriatric mental health; high risk; improved; indexing; inflammatory marker; lifestyle factors; men; middle age; modifiable risk; molecular marker; poor sleep; promoter; recruit; sex; skills; sleep quality; transcription factor; translational physician

SUMMARY/ABSTRACT The proposed K23 application will strongly support Ellen Lee, MD’s long-term career goal of becoming an independent clinical-translational physician-scientist in geriatric mental health. This project investigates inflammatory mechanisms underlying sleep and cognition in middle-aged and older adults (41-70 years old) with schizophrenia (SZ). The proposal has considerable

摘要/摘要 拟议的 K23 应用程序将有力支持 Ellen Lee 医学博士的长期职业目标，即成为老年心理健康领域的独立临床转化医师科学家。该项目研究中老年人（41-70 岁）精神分裂症 (SZ) 患者睡眠和认知的炎症机制。该提案具有相当大的

项目成果

Health Impacts of the Stay-at-Home Order on Community-Dwelling Older Adults and How Technologies May Help: Focus Group Study.

• DOI: 10.2196/25779
• 发表时间: 2021-03-22
• 期刊: JMIR aging
• 影响因子: 4.9
• 作者: Daly JR;Depp C;Graham SA;Jeste DV;Kim HC;Lee EE;Nebeker C
• 通讯作者: Nebeker C

Beyond artificial intelligence: exploring artificial wisdom.

• DOI: 10.1017/s1041610220000927
• 发表时间: 2020-08
• 期刊: International psychogeriatrics
• 影响因子: 7
• 作者: Jeste DV;Graham SA;Nguyen TT;Depp CA;Lee EE;Kim HC
• 通讯作者: Kim HC

Abbreviated San Diego Wisdom Scale (SD-WISE-7) and Jeste-Thomas Wisdom Index (JTWI).

• DOI: 10.1017/s1041610221002684
• 发表时间: 2022-07
• 期刊: INTERNATIONAL PSYCHOGERIATRICS
• 影响因子: 7
• 作者: Thomas, Michael L.;Palmer, Barton W.;Lee, Ellen E.;Liu, Jinyuan;Daly, Rebecca;Tu, Xin M.;Jeste, Dilip V.
• 通讯作者: Jeste, Dilip V.

Study of loneliness and wisdom in 482 middle-aged and oldest-old adults: a comparison between people in Cilento, Italy and San Diego, USA.

• DOI: 10.1080/13607863.2020.1821170
• 发表时间: 2021-11
• 期刊: Aging & mental health
• 影响因子: 3.4
• 作者: Jeste DV;Di Somma S;Lee EE;Nguyen TT;Scalcione M;Biaggi A;Daly R;Liu J;Tu X;Ziedonis D;Glorioso D;Antonini P;Brenner D
• 通讯作者: Brenner D

American Psychiatric Association's Leadership Fellowship Program: Short-term and Longer-term Outcomes.

• DOI: 10.1007/s40596-020-01339-1
• 发表时间: 2021-04
• 期刊: Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry
• 作者: Jeste DV;Patel S;Lee EE;Daly R;Govind T;Parekh R;Levin S
• 通讯作者: Levin S