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Novel Ultrasound Based Viscoelasticity Imaging Tool to Reduce Invasive Breast Lesion Biopsy Rate

新型超声粘弹性成像工具可降低乳腺浸润性病变活检率

基本信息

批准号：
10603447
负责人：
Julie Lundstrom
金额：
$ 29.87万
依托单位：
RUSH RIVER RESEARCH CORPORATION
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-08 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10603447
关键词：
Appointment Area Behavior Benign Biomedical Engineering Biopsy Breast Cancer Etiology Cessation of life Classification Clinic Clinical Clinical Trials Collaborations Complex Computer software Custom Data Analyses Decision Making Device Designs Devices Diagnostic Diagnostic Procedure Diagnostic tests Disease Doctor of Medicine Doctor of Philosophy Early Diagnosis Economic Burden Elasticity Electrical Engineering Emotional Engineering Favorable Clinical Outcome Feedback Female Frequencies Head Health Care Visit Image Imaging Device International Intervention Lesion Letters Logistic Regressions Magnetic Resonance Imaging Malignant - descriptor Malignant Neoplasms Mammary Gland Parenchyma Mammography Measurement Measures Mechanics Medical Device Medicine Methods Minor Modeling Movement Performance Phase Physicians Physiology Positioning Attribute Radiology Specialty Ramp Research Research Personnel Resources Rivers Science Specificity Stress System Technology Testing Tissues Ultrasonography United States Woman arm base breast cancer diagnosis breast imaging breast lesion cancer imaging college cost design design and construction diagnostic accuracy diagnostic technologies diagnostic tool diagnostic value emotional distress experience follow-up malignant breast neoplasm noninvasive diagnosis novel professor prototype psychological distress radiologist research and development response screening tool tumor ultrasound user-friendly viscoelasticity

项目摘要

Project Summary/Abstract Rush River Research Corporation, in collaboration with the Mayo Clinic, proposes to develop a novel, user- friendly, non-invasive diagnostic tool to measure viscoelasticity of breast tissue which can be used to characterize breast lesions as benign or malignant. Breast cancer is the second most common malignancy among women in the United States and a leading cause of cancer-related deaths in females. The diagnostic journey typically involves multiple screenings and follow-on diagnostics techniques. Following positive results from these less invasive diagnostics, a biopsy is typically performed. However, most biopsies performed on women who screened positive for breast cancer using typical screening methods are found to be benign. This results in a large physical, emotional, and economic burden experienced by women who do not have cancer. Additionally, the cost of potentially unwarranted benign biopsies is more than $2 billion annually in the United States. The proposed new tool to measure viscoelasticity of tissue will provide quantitative feedback on who should receive a biopsy as well as a 2D colormap image of the tumor. The novel tool uses existing ultrasound machines and ultrasound heads and can be done at the same appointment as a diagnostic ultrasound using the same machine. A mechanical attachment is required to provide an automated, force-controlled, dynamic, axial compression and will be developed and tested using phantoms in this project. This technology will provide physicians with a better tool for decision-making and help women avoid unnecessary biopsies.

项目总结/文摘