Integration of a multi-pronged standardized methodology to identify key diseases and prioritized antimicrobial alternatives in production animals

项目总结 抗菌素耐药性(AMR)被认为是对动物健康的重大威胁， 人类和植物，导致呼吁改善所有部门的抗菌剂管理。按顺序 为了确保最有效地利用有限的资源，迫切需要确定 疾病和相关的替代战略，如果实施，将导致最大的 对改善抗菌药物管理的影响。这项提议旨在解决这一关键差距。 采用一种整合了循证和决策方法的方法，例如 范围审查，结构化的专家启发(在某些情况下通过专有的大型- 规模数据和经验)，以及针对四头牲畜的多标准决策分析(MCDA 组。这种方法提供了一个全面、系统和透明的框架来 确定最重要的疾病并确定其优先顺序，然后确定最有希望的替代方案 减少食用动物使用医学上重要的抗菌剂的方法，同时 维护动物健康和福祉。相比之下，拟议中的项目意义重大 在目前的情况下，该项目的成功完成将产生全面和 对疾病驱动因素的细微差别评估和如何缓解的建议 抗菌剂在鸡、肉牛、奶牛和猪中的应用。这种综合的方法论， 结合对四个主要粮食生产品种的应用，允许一致和 解决FDA在此PAR中概述的特定需求的创新方法。这一努力 将由国家抗菌素耐药性研究和教育研究所领导 (NIAMRRE)，一个促进跨部门参与的成员组织，以打击 AMR与非营利性研究机构RTI International合作提出的挑战 具有范围审查、专家启发和多标准决策分析方面的专业知识。 NIAMRRE的专长包括来自四个主要国家的调查人员和主题专家 在动物健康和畜牧生产方面拥有深厚专业知识的农业研究型大学： 加州大学戴维斯分校(奶牛铅)、俄亥俄州立大学(肉牛铅)、 乔治亚大学(肉鸡铅)和爱荷华州立大学(猪铅)。总而言之， 这支团队为项目的顺利完成提供了出色的环境。这个 这一框架的结果是，将在四个主要领域采用一致的方法 牲畜物种，从而一致地传达关于战略的建议 减少对医学上重要的抗菌药的依赖。

PROJECT SUMMARY Antimicrobial resistance (AMR) is recognized as a significant threat to the health of animals, humans and plants, leading to calls to improve antimicrobial stewardship in all sectors. In order to assure the best utilization of limited resources, there is a critical need to identify the diseases and associated alternative strategies that, if implemented, would lead to the greatest impact on improving antimicrobial stewardship. This proposal seeks to address this critical gap with an approach that integrates evidence-based and decision-making methods such as scoping reviews, structured expert elicitations (informed in some cases by proprietary large- scale data and experience), and multi-criteria decision analysis (MCDA) across four livestock groups. This approach provides a comprehensive, systematic, and transparent framework to identify and prioritize the most important disease, and then the most promising alternative approaches to reduce the use of medically important antimicrobials in food animals, while maintaining animal health and wellbeing. The proposed project is significant in that, in contrast to the present situation, successful completion of the project will generate comprehensive and nuanced assessments of the disease drivers and recommendations on how to mitigate antimicrobial use in chickens, beef cattle, dairy cattle and swine. This integrated methodology, combined with application to four major food producing species, allows for a consistent and innovative approach to addressing the specific needs outlined by FDA in this PAR. This effort will be led by the National Institute of Antimicrobial Resistance Research and Education (NIAMRRE), a member organization that fosters cross-sector engagement to combat the challenges presented by AMR, in collaboration with RTI International, a nonprofit research institute with expertise in scoping reviews, expert elicitation, and multi-criteria decision analysis. NIAMRRE expertise includes investigators and subject matter experts from four major agricultural research universities with deep expertise in animal health and livestock production: University of California Davis (dairy cattle lead), The Ohio State University (beef cattle lead), the University of Georgia (broiler chicken lead), and Iowa State University (swine lead). Collectively, this team provides an outstanding environment for successful completion of the project. The outcome of this framework is that a consistent approach will be applied across four major livestock species, resulting in consistent communications of recommendations for strategies to reduce reliance on medically important antimicrobials.