Role and Mechanism of Hearing Impairment in Cognitive Decline and Dementia

听力障碍在认知衰退和痴呆中的作用和机制

• 批准号: 10600208
• 负责人: JENNIFER Anne DEAL
• 金额: $ 12.63万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-15 至 2023-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10600208
• 关键词: Acoustic Stimulation; Address; Affect; Age; Aging; Air; Alzheimer' s Disease; Alzheimer' s disease brain; Amyloid beta-Protein; Ankle; Applications Grants; Appointment; Area; Atherosclerosis Risk in Communities; Attenuated; Audiology; Auditory; Award; Baltimore; Biological Markers; Blood Vessels; Brain; Brain imaging; Brain region; Cerebrovascular Disorders; Cerebrum; Clinic; Clinical; Clinical Research; Cognitive; Cognitive aging; Data; Data Analyses; Dementia; Development; Diabetes Mellitus; Diagnosis; Disease; Disease Marker; Educational workshop; Elderly; Epidemiologist; Epidemiology; Five-Year Plans; Functional disorder; Funding; Fundus photography; Future; Goals; Head and Neck Surgery; Health; Healthcare; Hearing; Hearing Aids; Hearing Tests; Hypertension; Impaired cognition; Individual; Interdisciplinary Study; Intervention; K-Series Research Career Programs; Knowledge; Lacunar Infarctions; Lead; Longitudinal Studies; Magnetic Resonance Imaging; Measures; Mentors; Methods; Obesity; Observational Study; Otolaryngology; Participant; Pathology; Pathway interactions; Peripheral; Population Study; Positioning Attribute; Poverty; Process; Publications; Publishing; Pure-Tone Audiometry; Reporting; Research; Research Personnel; Resources; Retina; Risk Factors; Role; Scientist; Signal Transduction; Smoking; Techniques; Testing; Time; Training; Training Programs; United States National Academy of Sciences; United States National Institutes of Health; Universities; White Matter Hyperintensity; abeta deposition; adjudicate; adverse outcome; aging brain; auditory processing; aural rehabilitation; base; brain volume; career; cerebrovascular; clinical translation; cognitive function; cognitive neuroscience; cohort; disability; empowered; epidemiology study; healthy aging; hearing impairment; imaging facilities; imaging science; improved; indexing; informal learning; insight; medical schools; middle age; modifiable risk; mortality; neurocognitive test; neuroimaging; neuron loss; prevent; prospective; skills; tau Proteins; vascular factor; vascular risk factor; β-amyloid burden

ABSTRACT Jennifer A. Deal is an epidemiologist and gerontologist, with a position as Assistant Scientist in the Department of Epidemiology, Johns Hopkins Bloomberg School of Medicine and a secondary appointment in the Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins School of Medicine. She seeks a mentored career development award to fill knowledge gaps in her current training so that her research can successfully bridge the diverse fields of cognitive aging, audiology, otolaryngology, epidemiology and cognitive neuroscience in order to improve the health of older adults. The training proposal describes a comprehensive five-year plan of formal and informal instruction in the clinical aspects and pathophysiology of hearing impairment, as well as the acquisition, analysis and processing of neuroimaging data in large population-based studies. The training program consists of didactic coursework and seminars, clinic observations, and mentored research by an established and diverse team of experts. Short-term career goals include completion and dissemination of high-quality mentored research through publications and presentations and application for independent R01 funding beginning in the fourth year of the award period. Long-term career goals are to be an independent investigator in the area of aging and cognitive decline and dementia, with expertise in hearing impairment. The specific aims of the proposed research are to quantify the independent association of HI incident dementia and with domain-specific cognitive decline in three well-characterized prospective observational studies, to investigate the relationship of HI with changes in brain volume over time (both in regions related to Alzheimer’s disease and to auditory processing), and to quantify the role of vascular factors in the development of HI. Completion of the proposed aims will elucidate the role and mechanism of hearing impairment in dementia and domain-specific cognitive decline, providing possible targets for future clinical research with the potential to inform efforts to prevent these adverse outcomes in older adults.

摘要

项目成果

Associations of dual sensory impairment with long-term depressive and anxiety symptoms in the United States.

• DOI: 10.1016/j.jad.2022.07.067
• 发表时间: 2022-11-15
• 期刊: JOURNAL OF AFFECTIVE DISORDERS
• 影响因子: 6.6
• 作者: Armstrong, Nicole M.;Teixeira, Camila Vieira Ligo;Gendron, Colby;Brenowitz, Willa D.;Lin, Frank R.;Swenor, Bonnelin;Powell, Danielle S.;Deal, Jennifer A.;Simonsick, Eleanor M.;Jones, Richard N.
• 通讯作者: Jones, Richard N.

Pilot Study of Audiometric Patterns in Fuchs Corneal Dystrophy.

福克斯角膜营养不良听力测定模式的初步研究。

• DOI: 10.1044/2018_jslhr-h-18-0088
• 发表时间: 2018
• 期刊: Journal of speech, language, and hearing research : JSLHR
• 作者: Reed,NicholasS;Deal,JenniferA;Huddle,MatthewG;Betz,JoshuaF;Bailey,BethanyE;McGlumphy,ElyseJ;Eghrari,AllenO;Riazuddin,SAmer;Lin,FrankR;Gottsch,JohnD
• 通讯作者: Gottsch,JohnD

Associations of Hearing Loss and Menopausal Hormone Therapy with Change in Global Cognition and Incident Cognitive Impairment among Postmenopausal Women.

• DOI: 10.1093/gerona/glz173
• 发表时间: 2019-07
• 期刊: The journals of gerontology. Series A, Biological sciences and medical sciences
• 作者: Nicole M. Armstrong;M. Espeland;J. Chen;K. Masaki;J. Wactawski‐Wende;Wenjun Li;M. Gass;M. Stefanick;J. Manson;J. Deal;S. Rapp;F. Lin;S. Resnick

Prevalence of Asymmetric Hearing Among Adults in the United States.

• DOI: 10.1097/mao.0000000000002931
• 发表时间: 2021-02-01
• 期刊: OTOLOGY & NEUROTOLOGY
• 影响因子: 2.1
• 作者: Suen, Jonathan J.;Betz, Joshua;Reed, Nicholas S.;Deal, Jennifer A.;Lin, Frank R.;Goman, Adele M.
• 通讯作者: Goman, Adele M.

Associations of dual sensory impairment with incident mobility and ADL difficulty.

• DOI: 10.1111/jgs.17764
• 发表时间: 2022-07
• 期刊: JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
• 影响因子: 6.3
• 作者: Armstrong, Nicole M.;Teixeira, Camila Vieira Ligo;Gendron, Colby;Brenowitz, Willa D.;Lin, Frank R.;Swenor, Bonnelin;Deal, Jennifer A.;Simonsick, Eleanor M.;Jones, Richard N.
• 通讯作者: Jones, Richard N.