权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Genetic Epidemiology of Caffeine and Cognitive Decline

咖啡因与认知衰退的遗传流行病学

基本信息

批准号：
10599678
负责人：
Marilyn C Cornelis
金额：
$ 12.33万
依托单位：
NORTHWESTERN UNIVERSITY AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-01 至 2023-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10599678
关键词：
Administrative Supplement Age-associated memory impairment Aging Alzheimer&apos s Disease Alzheimer&apos s disease pathology Amyloid Attenuated Autopsy Behavioral Biological COVID-19 Caffeine Chronic Coffee Cognition Cognitive aging Complex Data Dietary Factors Drug Kinetics Drug Targeting Drug usage Environmental Risk Factor Epidemiology Episodic memory Exposure to Fostering Funding Genes Genetic Goals Human Impaired cognition Individual Ingestion Institutes Intake International Investigation Joints Knowledge Left Link Literature Maps Masks Measures Memory Mentors Metabolic Metabolism Modeling Neurofibrillary Tangles Pathologic Pathway interactions Patient Self-Report Physiological Play Population Population Study Prevention Reporting Research Research Personnel Role Senile Plaques Severities Single Nucleotide Polymorphism System Testing Therapeutic Agents Time Training Training Activity Training Programs Variant Woman Work behavioral pharmacology cognitive function cohort data curation effective therapy epidemiology study experience genetic epidemiology genome wide association study genome-wide indexing insight inter-individual variation men metabolic rate neuropathology novel nutrition prospective symposium trait

项目摘要

PROJECT SUMMARY Age-associated cognitive decline is an important human condition that varies in extent among individuals. This variation likely arises from a complex interplay of genetic and environmental factors. Caffeine is the most commonly ingested behaviorally active substance in the world, and a growing body of literature points to the premise that caffeine may provide a safe, effective, readily available, and inexpensive therapeutic agent against cognitive decline. However, factors that contribute to variation in caffeine metabolism may interact with caffeine intake and modify its association with cognitive decline. Furthermore, caffeine targets genes and pathways potentially impacting cognitive decline and thus an opportunity to advancing our understanding of this condition may be missed if variation in caffeine metabolism is left unaccounted for. Dr. Cornelis proposes a training and research plan that will contribute to her goal to become an independent investigator of systems epidemiology of nutrition and cognitive decline. To acquire training in i) cognitive function assessment ii) epidemiology of cognitive decline and iii) neuropathological aspects of cognitive decline and Alzheimer's disease, she works closely with a team of internationally recognized mentors from two highly reputable institutes committed to aging research and engages in training activities including coursework, one- on-one and small group sessions, seminars and conferences, observation and hands-on practicum. She will apply her training to the first comprehensive and highly efficient analysis of the joint effects of genetics and caffeine on cognitive decline. Composite indices of caffeine metabolic rate and caffeine exposure will be used in an epidemiological meta-analytical framework to examine genecaffeine intake interactions and cognitive decline and to discover novel loci for this condition by modeling SNPcaffeine exposure interactions on a genome-wide scale. Dr. Cornelis's research will provide critical insights into the role that caffeine potentially plays in slowing cognitive decline and has potential to uncover novel biological pathways underlying this condition. Results of this work should foster new lines of investigation for cognitive impairment and for developing novel behavioral and pharmacological avenues for safe and effective treatment and prevention. Moreover, the experience and knowledge obtained from the completion of Dr. Cornelis's training and research plan will allow her to obtain R01 funding to acquire additional systems-level data for a more detailed mechanistic view of how caffeine or other dietary factors impact cognitive decline. This Administrative Supplement will allow Dr. Cornelis to complete her K01 training and research that was disrupted by COVID-19 shutdowns. Limited availability of cohorts and research staff for nutrition data curation required research revisions and more time. COVID-19 also disrupted the neuropathology training Dr. Cornelis needed to complete her K01 analyses in a timely manner.

项目总结

项目成果

期刊论文数量（9）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Diet and Respiratory Infections: Specific or Generalized Associations?

DOI：
10.3390/nu14061195
发表时间：
2022-03-11
期刊：
Nutrients
影响因子：
5.9
作者：
Vu TT;Van Horn L;Achenbach CJ;Rydland KJ;Cornelis MC
通讯作者：
Cornelis MC

Mendelian Randomization Studies of Coffee and Caffeine Consumption.

DOI：
10.3390/nu10101343
发表时间：
2018-09-20
期刊：
Nutrients
影响因子：
5.9
作者：
Cornelis MC;Munafo MR
通讯作者：
Munafo MR

Mendelian randomization study of coffee consumption and age at onset of Huntington's disease.

DOI：
10.1016/j.clnu.2021.09.041
发表时间：
2021-11
期刊：
CLINICAL NUTRITION
影响因子：
6.3
作者：
Wang, Mengmeng;Cornelis, Marilyn C.;Zhang, Zhizhong;Liu, Dandan;Lian, Xuegan
通讯作者：
Lian, Xuegan

Recent consumption of a caffeine-containing beverage and serum biomarkers of cardiometabolic function in the UK Biobank.