Conduct of mechanistic studies on radio frequency radiation (RFR)

该项目的目标是为转化毒理学司（DTT）的危险识别活动提供支持，这些活动旨在预防因环境暴露于化学或物理剂而引起的疾病或不利影响。毒性试验是公共卫生研究的一个重要方面，因为它有助于确定对人类健康有害的化学品。需要进行适当的毒理学研究，以确保得出的数据可靠。DTT最近报告了对手机使用频率和调制的射频辐射进行毒性和致癌性研究的结果。大鼠的频率为900兆赫，小鼠的频率为1900兆赫。调制方式是GSM和CDMA。暴露时间为9小时10分钟，每天18小时20分钟（开10分钟/关10分钟）。这些研究的目的是对射频辐射进行后续的机理研究。这些研究将解决在进行和报告致癌性研究期间提出的问题，并将机制理解扩展到其他调节/暴露情景。这个项目的数据最终将帮助我们更好地理解对大鼠和小鼠的毒性和致癌性研究并支持数字地面电视的任务和目标以及其他联邦机构的风险评估活动。

The goal of this project is to provide support of the Division of Translational Toxicology (DTT) hazard identification activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents. Toxicity testing is an important aspect of public health research in that it serves to identify chemicals that are hazardous to human health. Proper conduct of toxicology studies is required to ensure that the resulting data are reliable. DTT recently reported the results of toxicity and carcinogenicity studies of radio frequency radiation at frequencies and modulations used by cell phones. Frequencies were 900 MHz in rats and 1900 MHz in mice. Modulations were GSM and CDMA. Exposures were 9 hr 10 min over an 18 hr 20 min period each day (10 min on/10 min off). The goal of these studies is to conduct follow on mechanistic studies on radio frequency radiation. These studies will address questions raised during conduct and reporting of the carcinogenicity studies and extend mechanistic understanding to additional modulations/exposure scenarios. Data from this project will ultimately allow a greater understanding of the toxicity and carcinogenicity studies in rats and mice and support of the mission and goals of DTT and risk assessment activities of other federal agencies. Keywords: radio frequency radiation, CDMA, GSM, modulation, frequency