Training to provide the knowledge, skills, and culture to the next generation of cardiovascular scientists

为下一代心血管科学家提供知识、技能和文化的培训

• 批准号: 10602446
• 负责人: Brandon J Biesiadecki
• 金额: $ 36.56万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10602446
• 关键词: Cardiovascular system; Knowledge; Scientist; Training; next generation; skills

PROJECT SUMMARY Cardiovascular disease remains the number one cause of death in the United States. The efficient development of future novel diagnostics and therapies to identify and treat cardiovascular disease will require highly collaborative and multi-disciplinary teams consisting of the best basic, translational and clinical investigators. To achieve this overarching goal, it will first be essential for cardiovascular researchers to possess multi-disciplinary skills and work in highly inter-disciplinary, collaborative and translational teams to efficiently move knowledge from the bench to the bedside, to the community and back. Second, to obtain optimal productivity towards improving cardiovascular health of the population, it is essential to utilize the contributions from the best of the entire scientific workforce. We have established a Training Program addressing these two unmet needs that will ultimately be required to optimally train and retain the next generation of the best cardiovascular investigators. The goals of this Training Program are: 1. To provide multi-faceted cardiovascular research training to work in collaborative, multidisciplinary teams that will facilitate efficient translation of scientific findings to improve human health. 2. To enhance the numbers of outstanding researchers and leaders by providing training for the advancement of women to all trainees, improving the culture for women to succeed, and promoting the retention of women in independent scientific careers in cardiovascular research. In addition to advanced Cardiac Physiology and Biostatistics coursework, Rigor and Reproducibility, and Responsible Conduct of Research Training, several innovative Program Activities were implemented in the first funding cycle to achieve these goals. Leadership Skills and Advancement of Women workshops supply both men and women with key professional development and leadership skills at the predoctoral level to improve the career trajectory of women and change the culture for women to succeed to retain the best scientific investigators at later career stages. These workshops also provide valuable networking opportunities for trainees with prominent visiting cardiovascular scientists. The Clinical Mentorship program allows trainees to learn the language and culture within clinical medicine and to develop the skills needed to form future collaborations with physicians. Molecular and Cellular Cardiophysiology research-in-progress presentations are highly interactive and improve both the research and presentation skills of the trainees as well as emphasize rigor and reproducibility. In this renewal, we will continue to expand upon these programs by also including Career Mentorship to meet the individualized career goals of trainees. At The Ohio State University, we have a highly collaborative and multi-disciplinary scientific infrastructure that has been created to support translational cardiovascular research, education, and training. The mentors on this T32 application are all established scientists in their field, have a passion for training, and are committed to the goals of this Training program.

项目摘要 心血管疾病仍然是美国的头号死因。高效发展 未来新的诊断和治疗，以确定和治疗心血管疾病将需要高度 由最好的基础、翻译和临床研究人员组成的协作和多学科团队。到 为了实现这一总体目标，心血管研究人员首先必须拥有多学科的知识， 在高度跨学科，协作和翻译团队中工作，以有效地转移知识 从长凳到床边，到社区，再到社区。第二，为了获得最佳生产力， 为了改善人口的心血管健康，必须利用最好的人的贡献， 全体科学工作者。我们已经建立了一个培训计划，解决这两个未满足的需求， 最终需要以最佳方式培训和留住下一代最好的心血管研究人员。 本培训方案的目标是： 1.提供多方面的心血管研究培训，以便在协作，多学科团队中工作 这将有助于有效地转化科学发现，以改善人类健康。 2.通过提供促进发展的培训，增加优秀研究人员和领导者的数量 提高妇女成功的文化，并促进留住妇女 从事心血管研究的独立科学事业。 除了先进的心脏生理学和生物统计学课程，僵硬和再现， 负责任的研究行为培训，几个创新的计划活动，在第一次实施 融资周期，以实现这些目标。领导技能和提高妇女地位讲习班既提供 在博士前一级具有关键专业发展和领导技能的男女，以提高 妇女的职业轨迹和改变文化，使妇女能够成功地留住最好的科学研究人员 在以后的职业生涯阶段。这些讲习班还为学员提供了宝贵的建立联系的机会， 杰出的心血管科学家临床导师计划允许学员学习 临床医学中的语言和文化，并发展形成未来合作所需的技能， 医生分子和细胞心脏生理学研究进展介绍是高度互动的 提高学员的研究和演讲技巧，并强调严谨性， 再现性在这次更新中，我们将继续扩大这些计划，包括职业生涯 指导以满足学员的个性化职业目标。在俄亥俄州州立大学， 协作和多学科的科学基础设施，已创建，以支持翻译 心血管研究、教育和培训。此T32应用程序上的导师均已建立 科学家在他们的领域，有培训的热情，并致力于本培训计划的目标。

项目成果

Loss of ADAMTS19 causes progressive non-syndromic heart valve disease.

ADAMTS19 的缺失会导致进行性非综合征性心脏瓣膜疾病。

• DOI: 10.1038/s41588-019-0536-2
• 发表时间: 2020
• 期刊: Nature genetics
• 影响因子: 30.8
• 作者: Wünnemann,Florian;Ta-Shma,Asaf;Preuss,Christoph;Leclerc,Severine;vanVliet,PatrickPiet;Oneglia,Andrea;Thibeault,Maryse;Nordquist,Emily;Lincoln,Joy;Scharfenberg,Franka;Becker-Pauly,Christoph;Hofmann,Philipp;Hoff,Kirstin;Audain,E
• 通讯作者: Audain,E

Non-contrast estimation of diffuse myocardial fibrosis with dual energy CT: A phantom study.

双重能量CT的弥漫性心肌纤维化的非对比度估计：一项幻影研究。

• DOI: 10.1016/j.jcct.2017.12.002
• 发表时间: 2018-01
• 期刊: Journal of cardiovascular computed tomography
• 影响因子: 5.4
• 作者: Kumar V;McElhanon KE;Min JK;He X;Xu Z;Beck EX;Simonetti OP;Weisleder N;Raman SV
• 通讯作者: Raman SV

Multiorgan, Multimodality Imaging in Cardiometabolic Disease.

• DOI: 10.1161/circimaging.117.005447
• 发表时间: 2017-11
• 期刊: Circulation. Cardiovascular imaging
• 作者: Kumar V;Hsueh WA;Raman SV
• 通讯作者: Raman SV

Intracellular Signaling Pathways Mediating Tyrosine Kinase Inhibitor Cardiotoxicity.

• DOI: 10.1016/j.hfc.2022.02.003
• 发表时间: 2022-07
• 期刊: HEART FAILURE CLINICS
• 影响因子: 3.4
• 作者: Scott, Shane S.;Greenlee, Ashley N.;Matzko, Anna;Stein, Matthew;Naughton, Michael T.;Zaramo, Taborah Z.;Schwendeman, Ethan J.;Mohammad, Somayya J.;Diallo, Mamadou;Revan, Rohith;Shimmin, Gabriel;Tarun, Shwetabh;Ferrall, Joel;Ho, Thai H.;Smith, Sakima A.
• 通讯作者: Smith, Sakima A.

The Notch Pathway: A Link Between COVID-19 Pathophysiology and Its Cardiovascular Complications.

• DOI: 10.3389/fcvm.2021.681948
• 发表时间: 2021
• 期刊: Frontiers in cardiovascular medicine
• 影响因子: 3.6
• 作者: Breikaa RM;Lilly B
• 通讯作者: Lilly B