Optimizing and understanding semantic feature analysis treatment for aphasia: A randomized controlled comparative-effectiveness trial

优化和理解失语症的语义特征分析治疗:一项随机对照比较有效性试验

基本信息

  • 批准号:
    10610579
  • 负责人:
  • 金额:
    $ 1.02万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-09-01 至 2024-08-31
  • 项目状态:
    已结题

项目摘要

The parent study for this administrative supplement is a randomized comparative effectiveness trial that examines whether active manipulation of a key component of semantic feature analysis (SFA) treatment for word-finding difficulty in aphasia improves outcomes. The component in question is the number of semantic features that persons with aphasia are asked to generate on each treatment trial. Study participants (n=40) will be recruited and randomized to receive either a many-features version of SFA or a few-features version. In the many-features condition, participants will be asked to generate 11 semantic features for each word practiced. Participants assigned to the few-features condition will be asked to generate 5 features for each word practiced. The total treatment time will be equated in the two conditions. Because each trial will take less time in the few-features condition, participants in this group will cycle through the lists of treated items more often, providing them with more opportunities to practice the phonological form of the targets, at the expense of more elaborated feature generation practice. Correspondingly, the many-features group will receive more practice generating semantic features, at the expense of having fewer opportunities to practice the target word forms. Study participants will be housed locally at the Pittsburgh site for five weeks during which they will receive 60 hours of SFA treatment. At two timepoints before beginning treatment, at treatment exit, and at 1-month follow-up, their ability to name pictures of treated and untreated, semantically related nouns will be assessed. Other secondary outcomes, including measures of connected speech and patient-reported communication ability will also be collected on the same schedule. In order to address unresolved questions about the underlying cognitive and neural mechanisms of SFA, a subset of participants will also receive concurrent pre- and post-treatment assessment of automatic word processing ability using eye-tracking methods and functional magnetic resonance imaging (fMRI). The language testing results will be used to determine the appropriate balance of feature generation practice vs. word form practice to optimize SFA outcomes. The eye-tracking results will be used to infer whether SFA’s positive effects can be attributed to improved activation of lexical-semantic representations, improved ability to inhibit competing representations, or both. The fMRI results will be used to identify the brain networks and activation changes associated with changes in naming ability resulting from SFA. This study will provide theoretically and clinically relevant information about how aphasia treatment should be delivered and the neurocognitive mechanisms underlying its effects. The aim of this administrative supplement project is to examine whether task-based brain activation patterns associated with language performance are stable across the two pre-treatment scanning sessions i to condition the interpretation of changes observed following treatment.
这项行政补充的母体研究是一项随机比较有效性试验, 检查语义特征分析(SFA)处理的关键组件的主动操作是否 失语症的单词查找困难改善了结果。所讨论的成分是语义的数量 失语症患者被要求在每次治疗试验中产生的特征。40名研究参与者将 被招募并随机接受SFA的多功能版本或少数功能版本。在 在多特征条件下,参与者将被要求为每个练习的单词生成11个语义特征。 分配到少要素条件的参与者将被要求为每个单词生成5个要素 练习过了。在这两种情况下,总治疗时间将相等。因为每次审判都会花费更少的时间 在特征较少的情况下,这一组的参与者将更频繁地循环浏览治疗物品的列表, 为他们提供更多的机会来练习目标语的语音形式,但代价是 详细阐述了特征生成的实践。相应地,多功能小组将得到更多的练习 生成语义特征,代价是练习目标词形式的机会较少。 研究参与者将在匹兹堡当地住宿五周,在此期间他们将接受 SFA治疗60小时。在开始治疗前的两个时间点、治疗结束时和一个月时 随后,将评估他们命名处理过的和未处理的语义相关名词的图片的能力。 其他次要结果,包括对连接的语言和患者报告的交流的衡量 能力也将在相同的时间表上收集。为了解决尚未解决的关于 在SFA的认知和神经机制基础上,一部分参与者也将同时接受Pre 以及使用眼球跟踪方法和 功能磁共振成像(FMRI)。 语言测试结果将用于确定特征生成的适当平衡 练习与单词形式练习相比,以优化SFA结果。眼睛跟踪结果将被用来推断 SFA的积极作用是否可以归因于词汇-语义表征的激活, 改进了抑制竞争表示法或两者兼而有之的能力。FMRI结果将被用来识别大脑 与SFA导致的命名能力变化相关联的网络和激活变化。这项研究将 提供有关如何治疗失语症的理论和临床相关信息 其影响背后的神经认知机制。这一行政补充项目的目的是 检查与语言表现相关的基于任务的大脑激活模式是否稳定 两次治疗前扫描会议I,以条件解释以下观察到的变化 治疗。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Michael Walsh Dickey其他文献

Michael Walsh Dickey的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Michael Walsh Dickey', 18)}}的其他基金

Optimizing and understanding semantic feature analysis treatment for aphasia: A randomized controlled comparative-effectiveness trial
优化和理解失语症的语义特征分析治疗:一项随机对照比较有效性试验
  • 批准号:
    10244949
  • 财政年份:
    2019
  • 资助金额:
    $ 1.02万
  • 项目类别:
Optimizing and understanding semantic feature analysis treatment for aphasia: A randomized controlled comparative-effectiveness trial
优化和理解失语症的语义特征分析治疗:一项随机对照比较有效性试验
  • 批准号:
    10000877
  • 财政年份:
    2019
  • 资助金额:
    $ 1.02万
  • 项目类别:
Optimizing and understanding semantic feature analysis treatment for aphasia: A randomized controlled comparative-effectiveness trial
优化和理解失语症的语义特征分析治疗:一项随机对照比较有效性试验
  • 批准号:
    10466962
  • 财政年份:
    2019
  • 资助金额:
    $ 1.02万
  • 项目类别:
Optimizing and understanding semantic feature analysis treatment for aphasia: A randomized controlled comparative-effectiveness trial
优化和理解失语症的语义特征分析治疗:一项随机对照比较有效性试验
  • 批准号:
    10688141
  • 财政年份:
    2019
  • 资助金额:
    $ 1.02万
  • 项目类别:
Dosage and predictors of naming treatment response in aphasia
失语症治疗反应的剂量和预测因素
  • 批准号:
    9136710
  • 财政年份:
    2013
  • 资助金额:
    $ 1.02万
  • 项目类别:
Dosage and predictors of naming treatment response in aphasia
失语症治疗反应的剂量和预测因素
  • 批准号:
    8984834
  • 财政年份:
    2013
  • 资助金额:
    $ 1.02万
  • 项目类别:
Neural Bases of Verb-Argument Processing
动词论元处理的神经基础
  • 批准号:
    8451368
  • 财政年份:
    2012
  • 资助金额:
    $ 1.02万
  • 项目类别:
Neural Bases of Verb-Argument Processing
动词论元处理的神经基础
  • 批准号:
    8297054
  • 财政年份:
    2012
  • 资助金额:
    $ 1.02万
  • 项目类别:
Neural Bases of Verb-Argument Processing
动词论元处理的神经基础
  • 批准号:
    8642637
  • 财政年份:
    2012
  • 资助金额:
    $ 1.02万
  • 项目类别:
Research Symposium in Clinical Aphasiology
临床失语症研究研讨会
  • 批准号:
    9944481
  • 财政年份:
    2003
  • 资助金额:
    $ 1.02万
  • 项目类别:

相似海外基金

A Longitudinal Qualitative Study of Fentanyl-Stimulant Polysubstance Use Among People Experiencing Homelessness (Administrative supplement)
无家可归者使用芬太尼兴奋剂多物质的纵向定性研究(行政补充)
  • 批准号:
    10841820
  • 财政年份:
    2023
  • 资助金额:
    $ 1.02万
  • 项目类别:
Proton-secreting epithelial cells as key modulators of epididymal mucosal immunity - Administrative Supplement
质子分泌上皮细胞作为附睾粘膜免疫的关键调节剂 - 行政补充
  • 批准号:
    10833895
  • 财政年份:
    2023
  • 资助金额:
    $ 1.02万
  • 项目类别:
Administrative Supplement: Life-Space and Activity Digital Markers for Detection of Cognitive Decline in Community-Dwelling Older Adults: The RAMS Study
行政补充:用于检测社区老年人认知衰退的生活空间和活动数字标记:RAMS 研究
  • 批准号:
    10844667
  • 财政年份:
    2023
  • 资助金额:
    $ 1.02万
  • 项目类别:
StrokeNet Administrative Supplement for the Funding Extension
StrokeNet 资助延期行政补充文件
  • 批准号:
    10850135
  • 财政年份:
    2023
  • 资助金额:
    $ 1.02万
  • 项目类别:
2023 NINDS Landis Mentorship Award - Administrative Supplement to NS121106 Control of Axon Initial Segment in Epilepsy
2023 年 NINDS 兰迪斯指导奖 - NS121106 癫痫轴突初始段控制的行政补充
  • 批准号:
    10896844
  • 财政年份:
    2023
  • 资助金额:
    $ 1.02万
  • 项目类别:
Biomarkers of Disease in Alcoholic Hepatitis Administrative Supplement
酒精性肝炎行政补充剂中疾病的生物标志物
  • 批准号:
    10840220
  • 财政年份:
    2023
  • 资助金额:
    $ 1.02万
  • 项目类别:
Administrative Supplement: Improving Inference of Genetic Architecture and Selection with African Genomes
行政补充:利用非洲基因组改进遗传结构的推断和选择
  • 批准号:
    10891050
  • 财政年份:
    2023
  • 资助金额:
    $ 1.02万
  • 项目类别:
Power-Up Study Administrative Supplement to Promote Diversity
促进多元化的 Power-Up 研究行政补充
  • 批准号:
    10711717
  • 财政年份:
    2023
  • 资助金额:
    $ 1.02万
  • 项目类别:
Administrative Supplement for Peer-Delivered and Technology-Assisted Integrated Illness Management and Recovery
同行交付和技术辅助的综合疾病管理和康复的行政补充
  • 批准号:
    10811292
  • 财政年份:
    2023
  • 资助金额:
    $ 1.02万
  • 项目类别:
Administrative Supplement: Genome Resources for Model Amphibians
行政补充:模型两栖动物基因组资源
  • 批准号:
    10806365
  • 财政年份:
    2023
  • 资助金额:
    $ 1.02万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了