Optimizing and understanding semantic feature analysis treatment for aphasia: A randomized controlled comparative-effectiveness trial
优化和理解失语症的语义特征分析治疗:一项随机对照比较有效性试验
基本信息
- 批准号:10610579
- 负责人:
- 金额:$ 1.02万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-09-01 至 2024-08-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAdministrative SupplementAftercareAphasiaBase of the BrainBrainBrain imagingCognitiveCommunicationDevelopmentEquilibriumFunctional Magnetic Resonance ImagingGenerationsGoalsHealthcareHourImageImpairmentLanguageLanguage TestsMeasuresMentorshipMethodsNamesNeurocognitiveOutcomeOutcome MeasureParentsParticipantPatientsPatternPerformancePersonsRandomizedReportingResearch PersonnelScanningScheduleSemanticsSiteSpeechStandardizationTest ResultTimeWord Processingclinically relevantcomparative effectiveness trialefficacious treatmentexperiencefollow-upimprovedimproved outcomelanguage processinglexicalneuromechanismphonologyrecruitsecondary outcomesuccesstreatment responsetreatment trialvisual tracking
项目摘要
The parent study for this administrative supplement is a randomized comparative effectiveness trial that
examines whether active manipulation of a key component of semantic feature analysis (SFA) treatment for
word-finding difficulty in aphasia improves outcomes. The component in question is the number of semantic
features that persons with aphasia are asked to generate on each treatment trial. Study participants (n=40) will
be recruited and randomized to receive either a many-features version of SFA or a few-features version. In the
many-features condition, participants will be asked to generate 11 semantic features for each word practiced.
Participants assigned to the few-features condition will be asked to generate 5 features for each word
practiced. The total treatment time will be equated in the two conditions. Because each trial will take less time
in the few-features condition, participants in this group will cycle through the lists of treated items more often,
providing them with more opportunities to practice the phonological form of the targets, at the expense of more
elaborated feature generation practice. Correspondingly, the many-features group will receive more practice
generating semantic features, at the expense of having fewer opportunities to practice the target word forms.
Study participants will be housed locally at the Pittsburgh site for five weeks during which they will receive
60 hours of SFA treatment. At two timepoints before beginning treatment, at treatment exit, and at 1-month
follow-up, their ability to name pictures of treated and untreated, semantically related nouns will be assessed.
Other secondary outcomes, including measures of connected speech and patient-reported communication
ability will also be collected on the same schedule. In order to address unresolved questions about the
underlying cognitive and neural mechanisms of SFA, a subset of participants will also receive concurrent pre-
and post-treatment assessment of automatic word processing ability using eye-tracking methods and
functional magnetic resonance imaging (fMRI).
The language testing results will be used to determine the appropriate balance of feature generation
practice vs. word form practice to optimize SFA outcomes. The eye-tracking results will be used to infer
whether SFA’s positive effects can be attributed to improved activation of lexical-semantic representations,
improved ability to inhibit competing representations, or both. The fMRI results will be used to identify the brain
networks and activation changes associated with changes in naming ability resulting from SFA. This study will
provide theoretically and clinically relevant information about how aphasia treatment should be delivered and
the neurocognitive mechanisms underlying its effects. The aim of this administrative supplement project is to
examine whether task-based brain activation patterns associated with language performance are stable across
the two pre-treatment scanning sessions i to condition the interpretation of changes observed following
treatment.
这种行政补充的母体研究是一项随机的比较效果试验
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Michael Walsh Dickey其他文献
Michael Walsh Dickey的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Michael Walsh Dickey', 18)}}的其他基金
Optimizing and understanding semantic feature analysis treatment for aphasia: A randomized controlled comparative-effectiveness trial
优化和理解失语症的语义特征分析治疗:一项随机对照比较有效性试验
- 批准号:
10000877 - 财政年份:2019
- 资助金额:
$ 1.02万 - 项目类别:
Optimizing and understanding semantic feature analysis treatment for aphasia: A randomized controlled comparative-effectiveness trial
优化和理解失语症的语义特征分析治疗:一项随机对照比较有效性试验
- 批准号:
10244949 - 财政年份:2019
- 资助金额:
$ 1.02万 - 项目类别:
Optimizing and understanding semantic feature analysis treatment for aphasia: A randomized controlled comparative-effectiveness trial
优化和理解失语症的语义特征分析治疗:一项随机对照比较有效性试验
- 批准号:
10466962 - 财政年份:2019
- 资助金额:
$ 1.02万 - 项目类别:
Optimizing and understanding semantic feature analysis treatment for aphasia: A randomized controlled comparative-effectiveness trial
优化和理解失语症的语义特征分析治疗:一项随机对照比较有效性试验
- 批准号:
10688141 - 财政年份:2019
- 资助金额:
$ 1.02万 - 项目类别:
Dosage and predictors of naming treatment response in aphasia
失语症治疗反应的剂量和预测因素
- 批准号:
9136710 - 财政年份:2013
- 资助金额:
$ 1.02万 - 项目类别:
Dosage and predictors of naming treatment response in aphasia
失语症治疗反应的剂量和预测因素
- 批准号:
8984834 - 财政年份:2013
- 资助金额:
$ 1.02万 - 项目类别:
相似海外基金
Proton-secreting epithelial cells as key modulators of epididymal mucosal immunity - Administrative Supplement
质子分泌上皮细胞作为附睾粘膜免疫的关键调节剂 - 行政补充
- 批准号:
10833895 - 财政年份:2023
- 资助金额:
$ 1.02万 - 项目类别:
A Longitudinal Qualitative Study of Fentanyl-Stimulant Polysubstance Use Among People Experiencing Homelessness (Administrative supplement)
无家可归者使用芬太尼兴奋剂多物质的纵向定性研究(行政补充)
- 批准号:
10841820 - 财政年份:2023
- 资助金额:
$ 1.02万 - 项目类别:
StrokeNet Administrative Supplement for the Funding Extension
StrokeNet 资助延期行政补充文件
- 批准号:
10850135 - 财政年份:2023
- 资助金额:
$ 1.02万 - 项目类别:
2023 NINDS Landis Mentorship Award - Administrative Supplement to NS121106 Control of Axon Initial Segment in Epilepsy
2023 年 NINDS 兰迪斯指导奖 - NS121106 癫痫轴突初始段控制的行政补充
- 批准号:
10896844 - 财政年份:2023
- 资助金额:
$ 1.02万 - 项目类别:
Biomarkers of Disease in Alcoholic Hepatitis Administrative Supplement
酒精性肝炎行政补充剂中疾病的生物标志物
- 批准号:
10840220 - 财政年份:2023
- 资助金额:
$ 1.02万 - 项目类别:
Administrative Supplement: Life-Space and Activity Digital Markers for Detection of Cognitive Decline in Community-Dwelling Older Adults: The RAMS Study
行政补充:用于检测社区老年人认知衰退的生活空间和活动数字标记:RAMS 研究
- 批准号:
10844667 - 财政年份:2023
- 资助金额:
$ 1.02万 - 项目类别:
Administrative Supplement: Improving Inference of Genetic Architecture and Selection with African Genomes
行政补充:利用非洲基因组改进遗传结构的推断和选择
- 批准号:
10891050 - 财政年份:2023
- 资助金额:
$ 1.02万 - 项目类别:
Power-Up Study Administrative Supplement to Promote Diversity
促进多元化的 Power-Up 研究行政补充
- 批准号:
10711717 - 财政年份:2023
- 资助金额:
$ 1.02万 - 项目类别:
Administrative Supplement for Peer-Delivered and Technology-Assisted Integrated Illness Management and Recovery
同行交付和技术辅助的综合疾病管理和康复的行政补充
- 批准号:
10811292 - 财政年份:2023
- 资助金额:
$ 1.02万 - 项目类别:
Administrative Supplement: Genome Resources for Model Amphibians
行政补充:模型两栖动物基因组资源
- 批准号:
10806365 - 财政年份:2023
- 资助金额:
$ 1.02万 - 项目类别:














{{item.name}}会员




