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The Functional Neuroanatomy of the Human Physiological Stress Response

人类生理应激反应的功能神经解剖学

基本信息

批准号：
10609821
负责人：
Gail Kurr Adler
金额：
$ 72.84万
依托单位：
BETH ISRAEL DEACONESS MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-05-15 至 2025-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10609821
关键词：
Acute Affect Affective Amygdaloid structure Baroreflex Blood Glucose Brain Brain region Cardiovascular Physiology Cardiovascular system Central Nervous System Closure by clamp Data Diabetes Mellitus Disease Emotional Emotional Stress Environment Equilibrium Esthesia Event Experimental Models Exposure to Foundations Functional Magnetic Resonance Imaging Future Health Hour Human Hyperalgesia Hypoglycemia Immune response Immune system Individual Inflammatory Insulin Life Magnetic Resonance Imaging Measures Medical Metabolic Methods Modeling Modernization Morbidity - disease rate Nervous System Neuroanatomy Neurosecretory Systems Norepinephrine Outcome Pain Patients Persons Physiological Predictive Value Procedures Psychological Impact Psychological Stress Psychosocial Stress Questionnaires Recovery Reporting Reproducibility Research Resolution Sensory Solid Stimulus Stress System Systems Integration Techniques Testing Time Woman biological adaptation to stress brain circuitry cardiovascular risk factor clinically relevant cytokine experience experimental study immune function men mortality neural circuit novel orthostatic stress pain perception physiologic model physiologic stressor psychologic psychosocial stressors resilience response restoration stressor

项目摘要

Stress, including physiological stress, is a ubiquitous aspect of modern life and has adverse health consequences including cardiovascular morbidity and mortality. However, few studies have examined the effects of physiological stressors on the nervous and cardiovascular systems, and the rate and extent of recovery of these systems from stress. In this proposal, we introduce a novel mechanistic, integrative approach to the assessment of the response to and recovery from a specific physiologic stressor – insulin-induced hypoglycemia. Our overall hypothesis is that a hypoglycemic stress will alter autonomic and sensory brain networks, and will affect clinically relevant physiological outcomes (cardiovascular autonomic function and sensory processing); and that the rate and extent of recovery of these brain networks will provide a measure of resilience Our Specific Aims are: 1) to identify, using function magnetic resonance imaging (fMRI), the effect of a controlled hypoglycemic stress on brain networks, with an emphasis on autonomic- and pain-related networks; 2) to determine the relationships between hypoglycemia-induced changes in brain networks and the physiological outcome of cardiovascular autonomic function; and 3) to determine the relationships between hypoglycemia-induced changes in brain networks and the physiological outcome of sensory processing In combination, this approach will allow us for the first time to define the magnitude of the effect of stress exposure on neural circuitry and on clinically relevant stress-related physiological outcomes (cardiovascular and sensory processing) and to define the recovery of brain circuitry and these related physiological outcomes. We will also assess the psychological impact of the study procedures and measure stress prior to and during the studies. This approach will provide an integrated system suitable for modeling resilience to physiological stress. If successful, our results will be relevant not only to patients with diabetes, who are frequently exposed to hypoglycemic stress, but may be generalizable to individuals exposed to other physiologic stresses. This proposal will also establish a scientific foundation for future studies to assess mechanisms involved in resilience to physiological stress, and the interactions between physiological and psychological stress.

压力，包括生理压力，是现代生活中无处不在的方面，对健康不利