Pilot Project Core

试点项目核心

• 批准号: 10609546
• 负责人: Thomas M McIntyre
• 金额: $ 8.96万
• 依托单位: CLEVELAND CLINIC LERNER COM-CWRU
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10609546
• 关键词: Alcohol abuse; Alcoholic Liver Diseases; Alcohols; Animal Model; Applications Grants; Area; Biological Assay; Biological Markers; Brain; Cell model; Cells; Child; Chronic; Clinic; Clinical; Clinical Investigator; Collaborations; Communities; Complex; Data; Development; Disease Progression; Disease susceptibility; Doctor of Philosophy; Elements; Environment; Ethanol; Ethanol Metabolism; Faculty; Fingerprint; Functional disorder; Funding; Future; Goals; Grant; Hepatic; Hepatic Encephalopathy; Human; Individual; Institution; Kidney Diseases; Magnetic Resonance; Medical center; Medicine; Microfilaments; Molecular Target; Monitor; Muscular Atrophy; Ohio; Organoids; Oxidation-Reduction; Pediatric Hospitals; Pilot Projects; Population; Proteome; Publications; Recovery; Research; Research Personnel; Role; Scientist; Sepsis; Sirtuins; System; Testing; Therapeutic Intervention; Tissues; Universities; alcohol exposure; alcohol research; alcohol response; alcohol use disorder; antimicrobial; biomarker development; clinical investigation; clinical translation; clinically relevant; college; depolymerization; developmental neurotoxicity; efficacy evaluation; exosome; flasks; gut microbiome; innovation; member; novel; novel strategies; novel therapeutic intervention; organ transplant recipient; oxidation; programs; response; success; targeted treatment; tissue injury; translational scientist; wound healing

ABSTRACT The overall goal of the Northeast Ohio Alcohol Center (NOAC) is to identify specific molecular targets responsible for ethanol-induced tissue damage, as well as to understand the complex adaptive and maladaptive responses of cells and systems to that damage. This information will enable us to 1) target therapeutic interventions to slow and/or reverse the progression of alcohol-induced tissue injury and 2) develop specific assays that can assess the efficacy of novel therapeutic strategies in relevant clinical populations. The NOAC brings together an outstanding team of interdisciplinary investigators including geneticists, cell biologists, oxidation biochemists, biomarker experts, synthetic chemists and clinical translational investigators. A critical element to leveraging the expertise of our team of investigators is to provide support for pilot projects. Pilot projects bring innovative and promising new approaches to the alcohol field and facilitate collaborations between team members and outside investigators to build onto their existing individual research programs. Pilot projects are supported by our Animal and Cell Models Core and Clinical Core, facilitating rapid progress for investigators new to the area of alcohol research. Importantly, the supportive intellectual environment with broad expertise in biomedical and clinical investigations will allow for the continued development of novel and innovative pilot projects. Therefore, support for pilot projects will likely have a large impact on the progress of research on mechanisms and treatments for ethanol-induced tissue injury. The Specific Aims of the Pilot Projects Core are to 1) Advertise the availability of Pilot Projects and invite pilot projects from faculty at Cleveland Clinic, Case Western Reserve University, MetroHealth Medical Center, Northeast Ohio College of Medicine and National Children’s Hospital, organize their review and ranking, 2) Provide support for junior investigators in implementing their proposals and 3) Monitor progress of Pilot Projects on a yearly basis. Implementation of the Pilot Projects Core will allow for funding of novel and innovative hypotheses with a rapid turnaround from conceptualization to actualization, facilitate collaborations between basic and clinical investigators and provide seed money to test exciting new approaches to understanding pathophysiology of ethanol-induced tissue injury, as well as development of biomarkers for disease progression and susceptibility. Importantly, the Pilot Projects Core will also extend the numbers of participating investigators in the NOAC and continue to build a community able and willing to conduct cutting edge basic and clinical alcohol-related research.

抽象的 东北俄亥俄州酒精中心 (NOAC) 的总体目标是确定负责的特定分子靶标 用于乙醇引起的组织损伤，以及了解复杂的适应性和适应不良反应 细胞和系统对这种损害的影响。这些信息将使我们能够 1) 有针对性的治疗干预措施，以减缓 和/或逆转酒精引起的组织损伤的进展，2) 开发可以评估的特定测定法 新治疗策略在相关临床人群中的疗效。 NOAC 汇集了 杰出的跨学科研究团队，包括遗传学家、细胞生物学家、氧化生物化学家、 生物标志物专家、合成化学家和临床转化研究人员。发挥作用的一个关键要素 我们研究团队的专业知识是为试点项目提供支持。试点项目带来创新和 有希望进入酒精领域的新方法并促进团队成员与外部之间的合作 研究人员以他们现有的个人研究项目为基础。试点项目得到了我们的动物的支持 以及细胞模型核心和临床核心，促进酒精领域新研究人员的快速进展 研究。重要的是，在生物医学和临床方面具有广泛专业知识的支持性智力环境 调查将有助于继续开发新颖和创新的试点项目。因此，支持 试点项目可能会对机制和治疗方法的研究进展产生重大影响 乙醇引起的组织损伤。试点项目核心的具体目标是 1) 宣传可用性 试点项目并邀请克利夫兰诊所、凯斯西储大学的教员进行试点项目， MetroHealth 医疗中心、东北俄亥俄医学院和国家儿童医院，组织 他们的审查和排名，2) 为初级研究人员实施其提案提供支持，3) 每年监控试点项目的进展情况。试点项目核心的实施将允许 资助新颖和创新的假设，从概念化到实现的快速转变， 促进基础研究人员和临床研究人员之间的合作，并提供种子资金来测试令人兴奋的新产品 了解乙醇引起的组织损伤的病理生理学的方法以及 疾病进展和易感性的生物标志物。重要的是，试点项目核心还将扩展 NOAC 中参与研究人员的数量，并继续建立一个能够并愿意开展研究的社区 酒精相关的前沿基础和临床研究。