Pilot Project Core
试点项目核心
基本信息
- 批准号:10609546
- 负责人:
- 金额:$ 8.96万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-05-01 至 2026-03-31
- 项目状态:未结题
- 来源:
- 关键词:Alcohol abuseAlcoholic Liver DiseasesAlcoholsAnimal ModelApplications GrantsAreaBiological AssayBiological MarkersBrainCell modelCellsChildChronicClinicClinicalClinical InvestigatorCollaborationsCommunitiesComplexDataDevelopmentDisease ProgressionDisease susceptibilityDoctor of PhilosophyElementsEnvironmentEthanolEthanol MetabolismFacultyFingerprintFunctional disorderFundingFutureGoalsGrantHepaticHepatic EncephalopathyHumanIndividualInstitutionKidney DiseasesMagnetic ResonanceMedical centerMedicineMicrofilamentsMolecular TargetMonitorMuscular AtrophyOhioOrganoidsOxidation-ReductionPediatric HospitalsPilot ProjectsPopulationProteomePublicationsRecoveryResearchResearch PersonnelRoleScientistSepsisSirtuinsSystemTestingTherapeutic InterventionTissuesUniversitiesalcohol exposurealcohol researchalcohol responsealcohol use disorderantimicrobialbiomarker developmentclinical investigationclinical translationclinically relevantcollegedepolymerizationdevelopmental neurotoxicityefficacy evaluationexosomeflasksgut microbiomeinnovationmembernovelnovel strategiesnovel therapeutic interventionorgan transplant recipientoxidationprogramsresponsesuccesstargeted treatmenttissue injurytranslational scientistwound healing
项目摘要
ABSTRACT
The overall goal of the Northeast Ohio Alcohol Center (NOAC) is to identify specific molecular targets responsible
for ethanol-induced tissue damage, as well as to understand the complex adaptive and maladaptive responses
of cells and systems to that damage. This information will enable us to 1) target therapeutic interventions to slow
and/or reverse the progression of alcohol-induced tissue injury and 2) develop specific assays that can assess
the efficacy of novel therapeutic strategies in relevant clinical populations. The NOAC brings together an
outstanding team of interdisciplinary investigators including geneticists, cell biologists, oxidation biochemists,
biomarker experts, synthetic chemists and clinical translational investigators. A critical element to leveraging the
expertise of our team of investigators is to provide support for pilot projects. Pilot projects bring innovative and
promising new approaches to the alcohol field and facilitate collaborations between team members and outside
investigators to build onto their existing individual research programs. Pilot projects are supported by our Animal
and Cell Models Core and Clinical Core, facilitating rapid progress for investigators new to the area of alcohol
research. Importantly, the supportive intellectual environment with broad expertise in biomedical and clinical
investigations will allow for the continued development of novel and innovative pilot projects. Therefore, support
for pilot projects will likely have a large impact on the progress of research on mechanisms and treatments for
ethanol-induced tissue injury. The Specific Aims of the Pilot Projects Core are to 1) Advertise the availability
of Pilot Projects and invite pilot projects from faculty at Cleveland Clinic, Case Western Reserve University,
MetroHealth Medical Center, Northeast Ohio College of Medicine and National Children’s Hospital, organize
their review and ranking, 2) Provide support for junior investigators in implementing their proposals and 3)
Monitor progress of Pilot Projects on a yearly basis. Implementation of the Pilot Projects Core will allow for
funding of novel and innovative hypotheses with a rapid turnaround from conceptualization to actualization,
facilitate collaborations between basic and clinical investigators and provide seed money to test exciting new
approaches to understanding pathophysiology of ethanol-induced tissue injury, as well as development of
biomarkers for disease progression and susceptibility. Importantly, the Pilot Projects Core will also extend the
numbers of participating investigators in the NOAC and continue to build a community able and willing to conduct
cutting edge basic and clinical alcohol-related research.
抽象的
东北俄亥俄州酒精中心 (NOAC) 的总体目标是确定负责的特定分子靶标
用于乙醇引起的组织损伤,以及了解复杂的适应性和适应不良反应
细胞和系统对这种损害的影响。这些信息将使我们能够 1) 有针对性的治疗干预措施,以减缓
和/或逆转酒精引起的组织损伤的进展,2) 开发可以评估的特定测定法
新治疗策略在相关临床人群中的疗效。 NOAC 汇集了
杰出的跨学科研究团队,包括遗传学家、细胞生物学家、氧化生物化学家、
生物标志物专家、合成化学家和临床转化研究人员。发挥作用的一个关键要素
我们研究团队的专业知识是为试点项目提供支持。试点项目带来创新和
有希望进入酒精领域的新方法并促进团队成员与外部之间的合作
研究人员以他们现有的个人研究项目为基础。试点项目得到了我们的动物的支持
以及细胞模型核心和临床核心,促进酒精领域新研究人员的快速进展
研究。重要的是,在生物医学和临床方面具有广泛专业知识的支持性智力环境
调查将有助于继续开发新颖和创新的试点项目。因此,支持
试点项目可能会对机制和治疗方法的研究进展产生重大影响
乙醇引起的组织损伤。试点项目核心的具体目标是 1) 宣传可用性
试点项目并邀请克利夫兰诊所、凯斯西储大学的教员进行试点项目,
MetroHealth 医疗中心、东北俄亥俄医学院和国家儿童医院,组织
他们的审查和排名,2) 为初级研究人员实施其提案提供支持,3)
每年监控试点项目的进展情况。试点项目核心的实施将允许
资助新颖和创新的假设,从概念化到实现的快速转变,
促进基础研究人员和临床研究人员之间的合作,并提供种子资金来测试令人兴奋的新产品
了解乙醇引起的组织损伤的病理生理学的方法以及
疾病进展和易感性的生物标志物。重要的是,试点项目核心还将扩展
NOAC 中参与研究人员的数量,并继续建立一个能够并愿意开展研究的社区
酒精相关的前沿基础和临床研究。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Thomas M McIntyre其他文献
Inhibition of Platelet-activating Factor Acetylhydrolase Activity by Oxidants. † 1541
氧化剂对血小板活化因子乙酰水解酶活性的抑制作用。†1541
- DOI:
10.1203/00006450-199704001-01560 - 发表时间:
1997-04-01 - 期刊:
- 影响因子:3.100
- 作者:
Amy N MacRitchie;Kun Qu;Diana M Stafforini;Thomas M McIntyre;Guy A Zimmerman;Stephen M Prescott - 通讯作者:
Stephen M Prescott
Thomas M McIntyre的其他文献
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{{ truncateString('Thomas M McIntyre', 18)}}的其他基金
Hypertension augmented COVID-19 through renin-induced internalization of platelet-ACE2 / SARS-Cov-2 complexes
高血压通过肾素诱导血小板-ACE2/SARS-Cov-2复合物内化增强了COVID-19
- 批准号:
10490385 - 财政年份:2021
- 资助金额:
$ 8.96万 - 项目类别:
Hypertension augmented COVID-19 through renin-induced internalization of platelet-ACE2 / SARS-Cov-2 complexes
高血压通过肾素诱导血小板-ACE2/SARS-Cov-2复合物内化增强了COVID-19
- 批准号:
10275251 - 财政年份:2021
- 资助金额:
$ 8.96万 - 项目类别:
Dynamic regulation of thrombosis by the platelet proteome
血小板蛋白质组对血栓形成的动态调节
- 批准号:
9336334 - 财政年份:2016
- 资助金额:
$ 8.96万 - 项目类别:
Systemic Oxidized Phospholipids in Mitochondrial Dysfunction of Alcoholic Injury
酒精损伤线粒体功能障碍中的全身氧化磷脂
- 批准号:
7671505 - 财政年份:2008
- 资助金额:
$ 8.96万 - 项目类别:
Systemic Oxidized Phospholipids in Mitochondrial Dysfunction of Alcoholic Injury
酒精损伤线粒体功能障碍中的全身氧化磷脂
- 批准号:
7522644 - 财政年份:2008
- 资助金额:
$ 8.96万 - 项目类别:
Systemic Oxidized Phospholipids in Mitochondrial Dysfunction of Alcoholic Injury
酒精损伤线粒体功能障碍中的全身氧化磷脂
- 批准号:
8318216 - 财政年份:2008
- 资助金额:
$ 8.96万 - 项目类别:
Systemic Oxidized Phospholipids in Mitochondrial Dysfunction of Alcoholic Injury
酒精损伤线粒体功能障碍中的全身氧化磷脂
- 批准号:
8135614 - 财政年份:2008
- 资助金额:
$ 8.96万 - 项目类别:
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