Pilot Project Core
试点项目核心
基本信息
- 批准号:10609546
- 负责人:
- 金额:$ 8.96万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-05-01 至 2026-03-31
- 项目状态:未结题
- 来源:
- 关键词:Alcohol abuseAlcoholic Liver DiseasesAlcoholsAnimal ModelApplications GrantsAreaBiological AssayBiological MarkersBrainCell modelCellsChildChronicClinicClinicalClinical InvestigatorCollaborationsCommunitiesComplexDataDevelopmentDisease ProgressionDisease susceptibilityDoctor of PhilosophyElementsEnvironmentEthanolEthanol MetabolismFacultyFingerprintFunctional disorderFundingFutureGoalsGrantHepaticHepatic EncephalopathyHumanIndividualInstitutionKidney DiseasesMagnetic ResonanceMedical centerMedicineMicrofilamentsMolecular TargetMonitorMuscular AtrophyOhioOrganoidsOxidation-ReductionPediatric HospitalsPilot ProjectsPopulationProteomePublicationsRecoveryResearchResearch PersonnelRoleScientistSepsisSirtuinsSystemTestingTherapeutic InterventionTissuesUniversitiesalcohol exposurealcohol researchalcohol responsealcohol use disorderantimicrobialbiomarker developmentclinical investigationclinical translationclinically relevantcollegedepolymerizationdevelopmental neurotoxicityefficacy evaluationexosomeflasksgut microbiomeinnovationmembernovelnovel strategiesnovel therapeutic interventionorgan transplant recipientoxidationprogramsresponsesuccesstargeted treatmenttissue injurytranslational scientistwound healing
项目摘要
ABSTRACT
The overall goal of the Northeast Ohio Alcohol Center (NOAC) is to identify specific molecular targets responsible
for ethanol-induced tissue damage, as well as to understand the complex adaptive and maladaptive responses
of cells and systems to that damage. This information will enable us to 1) target therapeutic interventions to slow
and/or reverse the progression of alcohol-induced tissue injury and 2) develop specific assays that can assess
the efficacy of novel therapeutic strategies in relevant clinical populations. The NOAC brings together an
outstanding team of interdisciplinary investigators including geneticists, cell biologists, oxidation biochemists,
biomarker experts, synthetic chemists and clinical translational investigators. A critical element to leveraging the
expertise of our team of investigators is to provide support for pilot projects. Pilot projects bring innovative and
promising new approaches to the alcohol field and facilitate collaborations between team members and outside
investigators to build onto their existing individual research programs. Pilot projects are supported by our Animal
and Cell Models Core and Clinical Core, facilitating rapid progress for investigators new to the area of alcohol
research. Importantly, the supportive intellectual environment with broad expertise in biomedical and clinical
investigations will allow for the continued development of novel and innovative pilot projects. Therefore, support
for pilot projects will likely have a large impact on the progress of research on mechanisms and treatments for
ethanol-induced tissue injury. The Specific Aims of the Pilot Projects Core are to 1) Advertise the availability
of Pilot Projects and invite pilot projects from faculty at Cleveland Clinic, Case Western Reserve University,
MetroHealth Medical Center, Northeast Ohio College of Medicine and National Children’s Hospital, organize
their review and ranking, 2) Provide support for junior investigators in implementing their proposals and 3)
Monitor progress of Pilot Projects on a yearly basis. Implementation of the Pilot Projects Core will allow for
funding of novel and innovative hypotheses with a rapid turnaround from conceptualization to actualization,
facilitate collaborations between basic and clinical investigators and provide seed money to test exciting new
approaches to understanding pathophysiology of ethanol-induced tissue injury, as well as development of
biomarkers for disease progression and susceptibility. Importantly, the Pilot Projects Core will also extend the
numbers of participating investigators in the NOAC and continue to build a community able and willing to conduct
cutting edge basic and clinical alcohol-related research.
摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Thomas M McIntyre其他文献
Inhibition of Platelet-activating Factor Acetylhydrolase Activity by Oxidants. † 1541
氧化剂对血小板活化因子乙酰水解酶活性的抑制作用。†1541
- DOI:
10.1203/00006450-199704001-01560 - 发表时间:
1997-04-01 - 期刊:
- 影响因子:3.100
- 作者:
Amy N MacRitchie;Kun Qu;Diana M Stafforini;Thomas M McIntyre;Guy A Zimmerman;Stephen M Prescott - 通讯作者:
Stephen M Prescott
Thomas M McIntyre的其他文献
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{{ truncateString('Thomas M McIntyre', 18)}}的其他基金
Hypertension augmented COVID-19 through renin-induced internalization of platelet-ACE2 / SARS-Cov-2 complexes
高血压通过肾素诱导血小板-ACE2/SARS-Cov-2复合物内化增强了COVID-19
- 批准号:
10490385 - 财政年份:2021
- 资助金额:
$ 8.96万 - 项目类别:
Hypertension augmented COVID-19 through renin-induced internalization of platelet-ACE2 / SARS-Cov-2 complexes
高血压通过肾素诱导血小板-ACE2/SARS-Cov-2复合物内化增强了COVID-19
- 批准号:
10275251 - 财政年份:2021
- 资助金额:
$ 8.96万 - 项目类别:
Dynamic regulation of thrombosis by the platelet proteome
血小板蛋白质组对血栓形成的动态调节
- 批准号:
9336334 - 财政年份:2016
- 资助金额:
$ 8.96万 - 项目类别:
Systemic Oxidized Phospholipids in Mitochondrial Dysfunction of Alcoholic Injury
酒精损伤线粒体功能障碍中的全身氧化磷脂
- 批准号:
7671505 - 财政年份:2008
- 资助金额:
$ 8.96万 - 项目类别:
Systemic Oxidized Phospholipids in Mitochondrial Dysfunction of Alcoholic Injury
酒精损伤线粒体功能障碍中的全身氧化磷脂
- 批准号:
7522644 - 财政年份:2008
- 资助金额:
$ 8.96万 - 项目类别:
Systemic Oxidized Phospholipids in Mitochondrial Dysfunction of Alcoholic Injury
酒精损伤线粒体功能障碍中的全身氧化磷脂
- 批准号:
8318216 - 财政年份:2008
- 资助金额:
$ 8.96万 - 项目类别:
Systemic Oxidized Phospholipids in Mitochondrial Dysfunction of Alcoholic Injury
酒精损伤线粒体功能障碍中的全身氧化磷脂
- 批准号:
8135614 - 财政年份:2008
- 资助金额:
$ 8.96万 - 项目类别:
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