Core D: Pilot Project Core

核心 D：试点项目核心

• 批准号: 8977737
• 负责人: Thomas M McIntyre
• 金额: $ 18.78万
• 依托单位: CLEVELAND CLINIC LERNER COM-CWRU
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-04-15 至 2021-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8977737
• 关键词: Advertising; Alcoholic Liver Diseases; Alcohols; American Society of Hematology; Animal Model; Area; Biological Assay; Biological Markers; Cell model; Cells; Clinic; Clinical; Clinical Investigator; Collaborations; Communities; Complex; Development; Disease Progression; Disease susceptibility; Doctor of Philosophy; Elements; Environment; Ethanol; Faculty; Fingerprint; Functional disorder; Funding; Future; Goals; Individual; Injury; Kidney Diseases; Magnetic Resonance; Medicine; Molecular Target; Monitor; Ohio; Pathogenesis; Pediatric Hospitals; Pilot Projects; Population; Research; Research Personnel; System; TNFRSF5 gene; Testing; Therapeutic Intervention; Tissues; Universities; alcohol research; base; biomarker development; clinical investigation; college; community building; exosome; flasks; innovation; member; novel; novel strategies; novel therapeutics; oxidation; programs; response; secretory IgM; targeted treatment

ABSTRACT The overall goal of the Northeast Ohio Alcohol Center (NOAC) is to identify specific molecular targets responsible for ethanol-induced tissue damage, as well as to understand the complex adaptive and maladaptive responses of cells and systems to that damage. This information will enable us to 1) target therapeutic interventions to slow and/or reverse the progression of alcohol-induced tissue injury and 2) develop specific assays that can assess the efficacy of novel therapeutic strategies in relevant clinical populations. The NOAC brings together an outstanding team of interdisciplinary investigators including geneticists, cell biologists, oxidation biochemists, biomarker experts, synthetic chemists and clinical translational investigators. A critical element to leveraging the expertise of our team of investigators is to provide support for pilot projects. Pilot projects bring innovative and promising new approaches to the alcohol field and facilitate collaborations between team members and outside investigators to build onto their existing individual research programs. Pilot projects are supported by our Animal and Cell Models Core and Clinical Core, facilitating rapid progress for investigators new to the area of alcohol research. Importantly, the supportive intellectual environment with broad expertise in biomedical and clinical investigations will allow for the continued development of novel and innovative pilot projects. Therefore, support for pilot projects will likely have a large impact on the progress of research on mechanisms and treatments for ethanol-induced tissue injury. The Specific Aims of the Pilot Projects Core are to 1) Advertise the availability of Pilot Projects and invite pilot projects from faculty at Cleveland Clinic, Case Western Reserve University, Northeast Ohio College of Medicine and National Children’s Hospital, organize their review and ranking, 2) Provide support for junior investigators in implementing their proposals and 3)Monitor progress of Pilot Projects on a yearly basis. Implementation of the Pilot Projects Core will allow for funding of novel and innovative hypotheses with a rapid turnaround from conceptualization to actualization, facilitate collaborations between basic and clinical investigators and provide seed money to test exciting new approaches to understanding pathophysiology of ethanol-induced tissue injury, as well as development of biomarkers for disease progression and susceptibility. Importantly, the Pilot Projects Core will also extend the numbers of participating investigators in the NOAC and continue to build a community able and willing to conduct cutting edge basic and clinical alcohol-related research.

抽象的 东北俄亥俄酒精中心（NOAC）的总体目标是确定特定的分子靶标 负责乙醇引起的组织损伤，并了解复杂的自适应和 细胞和系统对该损伤的适应不良反应。此信息将使我们能够到1） 治疗性干预措施以减慢和/或逆转酒精诱导的组织损伤的进展，2） 可以评估相关临床人群中新型治疗策略效率的特定评估。这 NOAC汇集了一个杰出的跨学科研究人员团队，包括遗传学家，细胞 生物学家，氧化生物化学家，生物标志物专家，合成化学家和临床转化研究者。 利用我们调查人员团队的专业知识的关键要素是为试点项目提供支持。 飞行员项目为酒精领域带来了创新和承诺的新方法，并促进合作 在团队成员和外部调查人员之间，以建立他们现有的个人研究计划。 试点项目得到我们的动物和细胞模型核心和临床核心的支持，支持快速进步 适用于酒精研究领域的调查人员。重要的是，由 生物医学和临床研究方面的广泛专业知识将允许持续发展新颖和 创新的飞行员项目。因此，对飞行员项目的支持可能会对 研究乙醇诱导的组织损伤的机制和治疗方法。飞行员的具体目的 项目核心是1）宣传试点项目的可用性，并邀请教职员工的试点项目 克利夫兰诊所，凯斯西部储备大学，东北俄亥俄州医学院和国家 儿童医院，组织他们的评论和排名，2）为初级调查人员提供支持 执行其建议和3）每年监控试点项目的进度。实施 飞行员项目核心将允许资助新颖和创新的假设，并以迅速的转变。 实现概念化，促进基本研究人员和临床研究者之间的合作 种子资金测试令人兴奋的新方法，以了解乙醇诱导的组织的病理生理学 损伤，以及用于疾病进展和易感性的生物标志物的发展。重要的是，飞行员 项目核心还将扩大NOAC参与调查人员的数量，并继续建造一个 社区能够并愿意进行尖端基本和临床酒精相关的研究。