Core D: Pilot Project Core

摘要 东北俄亥俄州酒精中心（NOAC）的总体目标是确定特定的分子靶点 负责乙醇诱导的组织损伤，以及了解复杂的适应性和 细胞和系统对这种损害的适应不良反应。这些信息将使我们能够1）瞄准 治疗性干预以减缓和/或逆转酒精诱导的组织损伤的进展，以及2）发展 可以评估新治疗策略在相关临床人群中的疗效的特定测定。的 NOAC汇集了一个优秀的跨学科研究团队，包括遗传学家，细胞 生物学家、氧化生物化学家、生物标志物专家、合成化学家和临床转化研究者。 利用我们调查员团队的专业知识的一个关键因素是为试点项目提供支持。 试点项目为酒精领域带来创新和有前途的新方法，并促进合作 在团队成员和外部研究人员之间建立联系，以建立他们现有的个人研究计划。 我们的动物和细胞模型核心和临床核心支持试点项目，促进快速进展 对于酒精研究领域的新研究者来说。重要的是，支持性的知识环境， 在生物医学和临床研究方面的广泛专业知识将允许继续开发新的和 创新试点项目。因此，对试点项目的支持可能会对项目的进展产生很大影响。 乙醇致组织损伤的机制和治疗研究。飞行员的具体目标 项目核心是1）确认试点项目的可用性，并邀请教师在 克利夫兰诊所，凯斯西储大学，东北俄亥俄州医学院和国立 儿童医院，组织他们的审查和排名，2）为初级研究者提供支持， 3）每年监测试点项目的进展情况。实施 核心试点项目将允许为新颖和创新的假设提供资金， 概念化到现实化，促进基础和临床研究者之间的合作，并提供 种子基金，以测试令人兴奋的新方法，以了解乙醇诱导组织的病理生理学 损伤，以及开发疾病进展和易感性的生物标志物。重要的是，飞行员 核心项目还将扩大参与NOAC的调查人员的数量，并继续建立一个 社区能够并愿意进行尖端的基础和临床酒精相关的研究。

ABSTRACT The overall goal of the Northeast Ohio Alcohol Center (NOAC) is to identify specific molecular targets responsible for ethanol-induced tissue damage, as well as to understand the complex adaptive and maladaptive responses of cells and systems to that damage. This information will enable us to 1) target therapeutic interventions to slow and/or reverse the progression of alcohol-induced tissue injury and 2) develop specific assays that can assess the efficacy of novel therapeutic strategies in relevant clinical populations. The NOAC brings together an outstanding team of interdisciplinary investigators including geneticists, cell biologists, oxidation biochemists, biomarker experts, synthetic chemists and clinical translational investigators. A critical element to leveraging the expertise of our team of investigators is to provide support for pilot projects. Pilot projects bring innovative and promising new approaches to the alcohol field and facilitate collaborations between team members and outside investigators to build onto their existing individual research programs. Pilot projects are supported by our Animal and Cell Models Core and Clinical Core, facilitating rapid progress for investigators new to the area of alcohol research. Importantly, the supportive intellectual environment with broad expertise in biomedical and clinical investigations will allow for the continued development of novel and innovative pilot projects. Therefore, support for pilot projects will likely have a large impact on the progress of research on mechanisms and treatments for ethanol-induced tissue injury. The Specific Aims of the Pilot Projects Core are to 1) Advertise the availability of Pilot Projects and invite pilot projects from faculty at Cleveland Clinic, Case Western Reserve University, Northeast Ohio College of Medicine and National Children’s Hospital, organize their review and ranking, 2) Provide support for junior investigators in implementing their proposals and 3)Monitor progress of Pilot Projects on a yearly basis. Implementation of the Pilot Projects Core will allow for funding of novel and innovative hypotheses with a rapid turnaround from conceptualization to actualization, facilitate collaborations between basic and clinical investigators and provide seed money to test exciting new approaches to understanding pathophysiology of ethanol-induced tissue injury, as well as development of biomarkers for disease progression and susceptibility. Importantly, the Pilot Projects Core will also extend the numbers of participating investigators in the NOAC and continue to build a community able and willing to conduct cutting edge basic and clinical alcohol-related research.