Core D: Pilot Project Core

摘要 俄亥俄州东北酒精中心(NOAC)的总体目标是确定特定的分子目标 负责酒精诱导的组织损伤，以及了解复杂的适应性和 细胞和系统对这种损伤的不适应反应。这些信息将使我们能够1)瞄准 治疗干预以减缓和/或逆转酒精诱导的组织损伤的进展和2)发展 可以评估新的治疗策略在相关临床人群中的有效性的具体分析。这个 NOAC汇聚了一支杰出的跨学科调查团队，其中包括遗传学家、细胞 生物学家、氧化生物化学家、生物标记物专家、合成化学家和临床翻译研究人员。 利用我们调查团队的专业知识的一个关键因素是为试点项目提供支持。 试点项目为酒精领域带来了创新和有前途的新方法，并促进了合作 团队成员和外部研究人员之间的合作，以加强他们现有的个人研究项目。 试点项目得到我们的动物和细胞模型核心和临床核心的支持，促进了快速进展 对于酒精研究领域的新手来说。重要的是，支持性的智力环境 生物医学和临床研究方面的广泛专业知识将使新的和 创新试点。因此，对试点项目的支持可能会对以下方面的进展产生重大影响 酒精性组织损伤的机制及治疗研究。试点的具体目标 项目核心将1)宣传试点项目的可用性，并邀请教职员工参加试点项目，网址为 克利夫兰诊所，凯斯西储大学，东北俄亥俄医学院和国家 儿童医院，组织他们的审查和排名，2)为初级调查人员提供支持 落实他们的建议；3)每年监测试点项目的进展情况。实施 试点项目核心将允许为新的和创新的假设提供资金，并迅速从 概念化到实施化，促进基础和临床研究人员之间的合作，并提供 种子资金用于测试了解酒精诱导组织病理生理学的令人兴奋的新方法 伤害，以及疾病进展和易感性的生物标志物的开发。重要的是，飞行员 Project Core还将扩大参与NOAC的调查人员的数量，并继续建立一个 社区有能力并愿意开展与酒精相关的前沿基础和临床研究。

ABSTRACT The overall goal of the Northeast Ohio Alcohol Center (NOAC) is to identify specific molecular targets responsible for ethanol-induced tissue damage, as well as to understand the complex adaptive and maladaptive responses of cells and systems to that damage. This information will enable us to 1) target therapeutic interventions to slow and/or reverse the progression of alcohol-induced tissue injury and 2) develop specific assays that can assess the efficacy of novel therapeutic strategies in relevant clinical populations. The NOAC brings together an outstanding team of interdisciplinary investigators including geneticists, cell biologists, oxidation biochemists, biomarker experts, synthetic chemists and clinical translational investigators. A critical element to leveraging the expertise of our team of investigators is to provide support for pilot projects. Pilot projects bring innovative and promising new approaches to the alcohol field and facilitate collaborations between team members and outside investigators to build onto their existing individual research programs. Pilot projects are supported by our Animal and Cell Models Core and Clinical Core, facilitating rapid progress for investigators new to the area of alcohol research. Importantly, the supportive intellectual environment with broad expertise in biomedical and clinical investigations will allow for the continued development of novel and innovative pilot projects. Therefore, support for pilot projects will likely have a large impact on the progress of research on mechanisms and treatments for ethanol-induced tissue injury. The Specific Aims of the Pilot Projects Core are to 1) Advertise the availability of Pilot Projects and invite pilot projects from faculty at Cleveland Clinic, Case Western Reserve University, Northeast Ohio College of Medicine and National Children’s Hospital, organize their review and ranking, 2) Provide support for junior investigators in implementing their proposals and 3)Monitor progress of Pilot Projects on a yearly basis. Implementation of the Pilot Projects Core will allow for funding of novel and innovative hypotheses with a rapid turnaround from conceptualization to actualization, facilitate collaborations between basic and clinical investigators and provide seed money to test exciting new approaches to understanding pathophysiology of ethanol-induced tissue injury, as well as development of biomarkers for disease progression and susceptibility. Importantly, the Pilot Projects Core will also extend the numbers of participating investigators in the NOAC and continue to build a community able and willing to conduct cutting edge basic and clinical alcohol-related research.